NRNP 6531 Week 2 Assignment 2026 | i-Human Integumentary Conditions 40 Questions
NRNP 6531 Week 2 Assignment 2026
i-Human Case Study: Evaluating and Managing Integumentary Conditions
40 Multiple-Choice Questions | Advanced Practice Nursing | Primary Care
Section 1: Clinical Assessment and Health History (Questions 1-10)
Q1: In the i-Human case of Krista Hampton, a 28-year-old landscape designer presents with a pruritic, vesicular rash on her
forearms and lower legs that began 48 hours after clearing brush on a job site. Which HPI component is MOST critical for
the advanced practice nurse to elicit next to narrow the differential diagnosis?
A. Duration of each individual lesion and whether new lesions continue to appear [CORRECT]
B. Family history of autoimmune disease
C. Last menstrual period date
D. Dietary intake over the past week
Correct Answer: A
Rationale: Understanding lesion timing and whether new lesions continue to appear is essential because allergic contact dermatitis (e.g.,
poison ivy/oak) typically presents with new lesions appearing over several days as the antigen reaction evolves, distinguishing it from
other conditions. In the i-Human case format, documenting this timing within the HPI directly supports the differential diagnosis and
meets assignment rubric criteria for comprehensive HPI documentation. Family history, while relevant, is less immediately diagnostic
than the evolution pattern.
Q2: Thomas Warren, a 62-year-old retired construction worker, presents to the i-Human virtual clinic for evaluation of a
pigmented lesion on his left shoulder. Which element of the social history is MOST relevant for assessing his skin cancer
risk?
A. His marital status and living situation
B. History of chronic outdoor occupational sun exposure and sunscreen use habits [CORRECT]
C. His exercise routine and dietary preferences
D. Travel history within the past six months
Correct Answer: B
Rationale: Decades of occupational sun exposure is a primary modifiable risk factor for melanoma and non-melanoma skin cancers. The
i-Human case player emphasizes SDOH-informed history taking, and documenting occupational UV exposure directly informs melanoma
risk stratification. While travel history may be relevant for exotic infections, chronic daily UV exposure is far more significant for skin
cancer risk assessment in this patient.
Q3: When documenting the History of Present Illness (HPI) for an integumentary complaint in the i-Human case player,
which of the following represents the MOST complete approach per the assignment rubric?
A. Documenting location, quality, and duration only
B. Documenting all eight HPI components: location, quality, severity, duration, timing, context, modifying factors, and
associated symptoms [CORRECT]
C. Documenting the chief complaint and a brief description
D. Documenting only the symptoms that the patient volunteers without structured prompting
Correct Answer: B
Rationale: The NRNP 6531 assignment rubric requires comprehensive HPI documentation using all eight OLDCARTS components.
Omitting any component represents a common i-Human scoring deficiency. For integumentary presentations, each component provides
critical diagnostic information: location maps to dermatomal or exposure patterns, quality distinguishes pruritic from painful lesions,
timing reveals acute versus chronic presentations, and modifying factors guide treatment selection.
Q4: Krista Hampton reports that the rash on her forearms is "extremely itchy" and rates it 7/10 in severity. She notes that
cool compresses provide mild temporary relief, but scratching worsens the erythema and causes new vesicles to form.
Page 1
, NRNP 6531 Week 2 Assignment 2026 | i-Human Integumentary Conditions 40 Questions
Which HPI component does the scratching behavior primarily represent?
A. Associated symptoms
B. Modifying factors [CORRECT]
C. Timing
D. Context
Correct Answer: B
Rationale: The scratching behavior that worsens the condition and the cool compresses that provide relief are classic modifying factors.
A common i-Human error is misclassifying modifying factors as associated symptoms or failing to document them at all. Modifying
factors directly influence treatment planning because they reveal both aggravating and alleviating behaviors that the patient education plan
should address.
Q5: In evaluating Thomas Warren for a suspicious pigmented lesion, which past medical history finding would MOST
significantly elevate his risk for malignant melanoma?
A. Controlled hypertension managed with lisinopril
B. History of atypical nevi and a prior excision of a dysplastic nevus [CORRECT]
C. History of seasonal allergic rhinitis
D. Remote appendectomy at age 22
Correct Answer: B
Rationale: A history of dysplastic nevi is one of the strongest independent risk factors for melanoma, particularly when combined with a
prior excision of an atypical nevus. The i-Human assignment rubric specifically requires identification of risk factors and their integration
into clinical reasoning. Controlled hypertension and allergic rhinitis have no meaningful association with melanoma risk, and failing to
recognize dysplastic nevus history is a common i-Human diagnostic error.
Q6: Which component of the Review of Systems (ROS) is MOST directly relevant when evaluating a patient with a
suspected fungal skin infection such as sporotrichosis in the i-Human case player?
A. Cardiovascular: chest pain and palpitations
B. Constitutional: fever, fatigue, and weight loss [CORRECT]
C. Genitourinary: dysuria and frequency
D. Neurological: headaches and visual changes
Correct Answer: B
Rationale: Sporotrichosis is a fungal infection caused by Sporothrix schenckii that can disseminate beyond the skin in
immunocompromised patients, producing constitutional symptoms such as fever, fatigue, and weight loss. The i-Human ROS section
requires targeted questioning that reflects clinical reasoning about potential systemic involvement. Constitutional symptoms in a patient
with nodular skin lesions following outdoor exposure should raise suspicion for disseminated sporotrichosis.
Q7: An advanced practice nurse is completing the i-Human case player documentation for a patient with seborrheic
dermatitis. Which medication class in the patient medication history would be MOST relevant to note as potentially
exacerbating this condition?
A. Beta-blockers for hypertension
B. Immunosuppressants such as systemic corticosteroids or biologics [CORRECT]
C. Statin therapy for hyperlipidemia
D. Proton pump inhibitors for GERD
Correct Answer: B
Rationale: Immunosuppressive medications can alter skin flora and immune surveillance, exacerbating conditions like seborrheic
dermatitis that involve Malassezia yeast overgrowth. In the i-Human medication review, recognizing drug-disease interactions is a key
assignment rubric element. While beta-blockers are associated with psoriasis flares, immunosuppressants have a broader impact on skin
conditions that depend on immune-mediated fungal control.
Q8: When collecting a family history in the i-Human case player for a patient presenting with multiple atypical moles,
which question is MOST important for melanoma risk stratification?
Page 2
NRNP 6531 Week 2 Assignment 2026
i-Human Case Study: Evaluating and Managing Integumentary Conditions
40 Multiple-Choice Questions | Advanced Practice Nursing | Primary Care
Section 1: Clinical Assessment and Health History (Questions 1-10)
Q1: In the i-Human case of Krista Hampton, a 28-year-old landscape designer presents with a pruritic, vesicular rash on her
forearms and lower legs that began 48 hours after clearing brush on a job site. Which HPI component is MOST critical for
the advanced practice nurse to elicit next to narrow the differential diagnosis?
A. Duration of each individual lesion and whether new lesions continue to appear [CORRECT]
B. Family history of autoimmune disease
C. Last menstrual period date
D. Dietary intake over the past week
Correct Answer: A
Rationale: Understanding lesion timing and whether new lesions continue to appear is essential because allergic contact dermatitis (e.g.,
poison ivy/oak) typically presents with new lesions appearing over several days as the antigen reaction evolves, distinguishing it from
other conditions. In the i-Human case format, documenting this timing within the HPI directly supports the differential diagnosis and
meets assignment rubric criteria for comprehensive HPI documentation. Family history, while relevant, is less immediately diagnostic
than the evolution pattern.
Q2: Thomas Warren, a 62-year-old retired construction worker, presents to the i-Human virtual clinic for evaluation of a
pigmented lesion on his left shoulder. Which element of the social history is MOST relevant for assessing his skin cancer
risk?
A. His marital status and living situation
B. History of chronic outdoor occupational sun exposure and sunscreen use habits [CORRECT]
C. His exercise routine and dietary preferences
D. Travel history within the past six months
Correct Answer: B
Rationale: Decades of occupational sun exposure is a primary modifiable risk factor for melanoma and non-melanoma skin cancers. The
i-Human case player emphasizes SDOH-informed history taking, and documenting occupational UV exposure directly informs melanoma
risk stratification. While travel history may be relevant for exotic infections, chronic daily UV exposure is far more significant for skin
cancer risk assessment in this patient.
Q3: When documenting the History of Present Illness (HPI) for an integumentary complaint in the i-Human case player,
which of the following represents the MOST complete approach per the assignment rubric?
A. Documenting location, quality, and duration only
B. Documenting all eight HPI components: location, quality, severity, duration, timing, context, modifying factors, and
associated symptoms [CORRECT]
C. Documenting the chief complaint and a brief description
D. Documenting only the symptoms that the patient volunteers without structured prompting
Correct Answer: B
Rationale: The NRNP 6531 assignment rubric requires comprehensive HPI documentation using all eight OLDCARTS components.
Omitting any component represents a common i-Human scoring deficiency. For integumentary presentations, each component provides
critical diagnostic information: location maps to dermatomal or exposure patterns, quality distinguishes pruritic from painful lesions,
timing reveals acute versus chronic presentations, and modifying factors guide treatment selection.
Q4: Krista Hampton reports that the rash on her forearms is "extremely itchy" and rates it 7/10 in severity. She notes that
cool compresses provide mild temporary relief, but scratching worsens the erythema and causes new vesicles to form.
Page 1
, NRNP 6531 Week 2 Assignment 2026 | i-Human Integumentary Conditions 40 Questions
Which HPI component does the scratching behavior primarily represent?
A. Associated symptoms
B. Modifying factors [CORRECT]
C. Timing
D. Context
Correct Answer: B
Rationale: The scratching behavior that worsens the condition and the cool compresses that provide relief are classic modifying factors.
A common i-Human error is misclassifying modifying factors as associated symptoms or failing to document them at all. Modifying
factors directly influence treatment planning because they reveal both aggravating and alleviating behaviors that the patient education plan
should address.
Q5: In evaluating Thomas Warren for a suspicious pigmented lesion, which past medical history finding would MOST
significantly elevate his risk for malignant melanoma?
A. Controlled hypertension managed with lisinopril
B. History of atypical nevi and a prior excision of a dysplastic nevus [CORRECT]
C. History of seasonal allergic rhinitis
D. Remote appendectomy at age 22
Correct Answer: B
Rationale: A history of dysplastic nevi is one of the strongest independent risk factors for melanoma, particularly when combined with a
prior excision of an atypical nevus. The i-Human assignment rubric specifically requires identification of risk factors and their integration
into clinical reasoning. Controlled hypertension and allergic rhinitis have no meaningful association with melanoma risk, and failing to
recognize dysplastic nevus history is a common i-Human diagnostic error.
Q6: Which component of the Review of Systems (ROS) is MOST directly relevant when evaluating a patient with a
suspected fungal skin infection such as sporotrichosis in the i-Human case player?
A. Cardiovascular: chest pain and palpitations
B. Constitutional: fever, fatigue, and weight loss [CORRECT]
C. Genitourinary: dysuria and frequency
D. Neurological: headaches and visual changes
Correct Answer: B
Rationale: Sporotrichosis is a fungal infection caused by Sporothrix schenckii that can disseminate beyond the skin in
immunocompromised patients, producing constitutional symptoms such as fever, fatigue, and weight loss. The i-Human ROS section
requires targeted questioning that reflects clinical reasoning about potential systemic involvement. Constitutional symptoms in a patient
with nodular skin lesions following outdoor exposure should raise suspicion for disseminated sporotrichosis.
Q7: An advanced practice nurse is completing the i-Human case player documentation for a patient with seborrheic
dermatitis. Which medication class in the patient medication history would be MOST relevant to note as potentially
exacerbating this condition?
A. Beta-blockers for hypertension
B. Immunosuppressants such as systemic corticosteroids or biologics [CORRECT]
C. Statin therapy for hyperlipidemia
D. Proton pump inhibitors for GERD
Correct Answer: B
Rationale: Immunosuppressive medications can alter skin flora and immune surveillance, exacerbating conditions like seborrheic
dermatitis that involve Malassezia yeast overgrowth. In the i-Human medication review, recognizing drug-disease interactions is a key
assignment rubric element. While beta-blockers are associated with psoriasis flares, immunosuppressants have a broader impact on skin
conditions that depend on immune-mediated fungal control.
Q8: When collecting a family history in the i-Human case player for a patient presenting with multiple atypical moles,
which question is MOST important for melanoma risk stratification?
Page 2
