MSN 571
absorption IM drug - pediatric - ANS-slow and erratic b/c of low blood flow
Absorption of drugs - ANS-Transfer of drugs from site of administration across cell membrane
into the blood stream
absorption oral drug- pediatric - ANS-delayed gastric emptying births to (6-8m)
decease acidity from birth to 2 years
absorption Transdermal drug - pediatric - ANS-rapid and complete bc striatum corner of infant
skin is very thin,
adverse drug reaction - ANS-any unexpected, unintended, undesired, or excessive response to
a medication given at therapeutic dosages (as opposed to overdose)
adverse drug reaction examples - ANS-allergic reaction, carcinogenic, teratogenic, hepatotoxic,
affect QT interval
adverse drug reaction-reaction-pediatric - ANS-glucocorticoids- growth supression
tetracyclines - discolored teet
Agonist - ANS-everts effects by activating receptor sites ; can make process so faster or slower
alcohol drug interactions - ANS-NSAIDS
CNS depressants
Tylenol
BP meds
alcohol metabolism - ANS-average approx 15 ml/hr = 1 drink per hour
alcohol physiologic effects - ANS-increase BP
increase risk f heart failure
Increase bone density
liver damage
gastritis
diuretic
decrease sexual function
cancer
affect fetus - pregnancy
Antagonist - ANS-produce effects by preventing receptor activation
, Beers List - ANS-a list of drugs with high likelihood of causing adverse effects in older adults
black box warning - ANS-strongest safety warning drug can have.
Dextromethorphan - ANS-Delsym; cough suppressant OTC ; abused by teenagers and
adolescent
distribution - pediatric - ANS-drug easily assess blood brain barrier
protein binding - amount of albumin is low
Distribution of drugs - ANS-movement of drugs from systemic circulation to site of drug action
Disulfiram - ANS-What drug is used to prevent alcohol consumption by causing unpleasant
effects
dose-response relationship - ANS-the relationship between the size of an administered dose
and the intensity it produces
drug ability to enter cell - ANS-binds with receptors on external surface of cell membrane
Drug ability to exit vascular system - ANS-capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
Drug affinity - ANS-strength of attraction between a drug and its receptor
drug excretion - ANS-elimination of a drug from the body
Drug Excretion Routes - ANS-renal
breast milk
bile
lungs
sweat
saliva
drug half life - ANS-the time required for the amount of drug in the body to decrease by 50%
Drug intrinsic activity - ANS-ability of drug to activate receptor upon binding.
drug metabolism - ANS-the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
absorption IM drug - pediatric - ANS-slow and erratic b/c of low blood flow
Absorption of drugs - ANS-Transfer of drugs from site of administration across cell membrane
into the blood stream
absorption oral drug- pediatric - ANS-delayed gastric emptying births to (6-8m)
decease acidity from birth to 2 years
absorption Transdermal drug - pediatric - ANS-rapid and complete bc striatum corner of infant
skin is very thin,
adverse drug reaction - ANS-any unexpected, unintended, undesired, or excessive response to
a medication given at therapeutic dosages (as opposed to overdose)
adverse drug reaction examples - ANS-allergic reaction, carcinogenic, teratogenic, hepatotoxic,
affect QT interval
adverse drug reaction-reaction-pediatric - ANS-glucocorticoids- growth supression
tetracyclines - discolored teet
Agonist - ANS-everts effects by activating receptor sites ; can make process so faster or slower
alcohol drug interactions - ANS-NSAIDS
CNS depressants
Tylenol
BP meds
alcohol metabolism - ANS-average approx 15 ml/hr = 1 drink per hour
alcohol physiologic effects - ANS-increase BP
increase risk f heart failure
Increase bone density
liver damage
gastritis
diuretic
decrease sexual function
cancer
affect fetus - pregnancy
Antagonist - ANS-produce effects by preventing receptor activation
, Beers List - ANS-a list of drugs with high likelihood of causing adverse effects in older adults
black box warning - ANS-strongest safety warning drug can have.
Dextromethorphan - ANS-Delsym; cough suppressant OTC ; abused by teenagers and
adolescent
distribution - pediatric - ANS-drug easily assess blood brain barrier
protein binding - amount of albumin is low
Distribution of drugs - ANS-movement of drugs from systemic circulation to site of drug action
Disulfiram - ANS-What drug is used to prevent alcohol consumption by causing unpleasant
effects
dose-response relationship - ANS-the relationship between the size of an administered dose
and the intensity it produces
drug ability to enter cell - ANS-binds with receptors on external surface of cell membrane
Drug ability to exit vascular system - ANS-capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
Drug affinity - ANS-strength of attraction between a drug and its receptor
drug excretion - ANS-elimination of a drug from the body
Drug Excretion Routes - ANS-renal
breast milk
bile
lungs
sweat
saliva
drug half life - ANS-the time required for the amount of drug in the body to decrease by 50%
Drug intrinsic activity - ANS-ability of drug to activate receptor upon binding.
drug metabolism - ANS-the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
