NGR 6172 Pharm EXAM 1 Questions with 100% Verified
Answers Latest Update
Question: Aspirin- MOA
Answer:
Binds irreversibly to cyclooxyrgenase-1 and 2 (COX 1 and 2)
Decrease prostaglandin and thromboxane A2 production
Question: Plavix (clopidogrel) -MOA
Answer:
Produg- irreversibly inhibits P2Y12 ADP-mediated platelet activation and aggregation
Question: Boxed warning of Plavix
Answer:
conversion to active metabolite require (CYP 450 2C19) Poor metabolizers - higher CV
events
Question: Plavix- avoid to take with what
Answer:
2c19 inhibitors (omeprazole, esomeprazole) increased bleed
Question: post CABG how long for antiplatelet therapy?
Answer:
1 year
Question: Post bare metal stent placement: how long for antiplatelet therapy?
Answer:
1 month or less
Question: Drug - eluting stent placement: how long for anti platelet therapy?
Answer:
6 months or less
Question: P2Y12 inhibitors MOA
Answer:
Binds the adenosine diphosphate (ADP) P2Y12 receptor on the platelet surface Prevents
activation of the GPIIb/IIIa receptor complex Reduces platelet aggregation
Answers Latest Update
Question: Aspirin- MOA
Answer:
Binds irreversibly to cyclooxyrgenase-1 and 2 (COX 1 and 2)
Decrease prostaglandin and thromboxane A2 production
Question: Plavix (clopidogrel) -MOA
Answer:
Produg- irreversibly inhibits P2Y12 ADP-mediated platelet activation and aggregation
Question: Boxed warning of Plavix
Answer:
conversion to active metabolite require (CYP 450 2C19) Poor metabolizers - higher CV
events
Question: Plavix- avoid to take with what
Answer:
2c19 inhibitors (omeprazole, esomeprazole) increased bleed
Question: post CABG how long for antiplatelet therapy?
Answer:
1 year
Question: Post bare metal stent placement: how long for antiplatelet therapy?
Answer:
1 month or less
Question: Drug - eluting stent placement: how long for anti platelet therapy?
Answer:
6 months or less
Question: P2Y12 inhibitors MOA
Answer:
Binds the adenosine diphosphate (ADP) P2Y12 receptor on the platelet surface Prevents
activation of the GPIIb/IIIa receptor complex Reduces platelet aggregation