CBNS 120 MT2 QUESTIONS WITH VERIFIED
ANSWERS
Quantum Content is ___________________, while quantal size is
________________________. - Answers - the number of quanta in a neurally evoked
synaptic response; the number of transmitter molecules in a quantum.
At negative membrane potentials, the motor endplate current is carried predominantly
by: - Answers - Na
At the vertebrate neuromuscular synapse, EEPC is approximately equal to: - Answers -
ENa-EK
When [Cl]o is replaced by isethionate, glycine application to a lamprey brainstem
neuron leads to: - Answers - increased permeability & no change in input resistance
At hippocampal GABAergic synapses, autoinhibition is mediated by: - Answers -
GABAB receptors & inhibition of presynaptic voltage-gated calcium channels
At hippocampal glutamatergic synapses, where the postsynaptic membrane potential is
-80 mV: - Answers - postsynaptic current is inward,postsynaptic current is sensitive to
CNQX, postsynaptic current flows exclusively through AMPA channels
At the vertebrate neuromuscular junction, stepping the postsynaptic membrane potential
to progressively more positive values results in: - Answers - a decrease in EPC
amplitude, reversal of the EPC from inward to outward at Em more positive than EEPC
The major factors contributing to synaptic delay are: - Answers - the time required for
opening of presynaptic calcium channels, .
the time required for exocytosis to occur
Yoshikami and Kuffler showed quantal size at the neuromuscular junction to be: -
Answers - ~7000
Exocytotic release of neurotransmitter is: - Answers - sensitive to temperature, sensitive
to calcium, and enhanced in the presence of 4-AP
Miniature end plate potentials (MEPPs): - Answers - are spontaneous events, are
quantal events.
Gap junctions - Answers - .
are cytoplasmic bridges, occur at electrical synapses
, The "kiss and run" mode of transmitter release - Answers - results in partial release of
neurotransmitter from the vesicle, occurs via a "fusion pore"
IPSPs - Answers - are hyperpolarizing membrane responses, result from an increase in
chloride conductance
The EPP at the vertebrate neuromuscular junction: - Answers - is a passive membrane
response, always exceeds threshold under natural conditions
Glial cells - Answers - - buffer [K]o
- depolarize in response to neuronal activity
- recycle neurotransmitters
Astrocytes: - Answers - - respond to neurotransmitters
- release neurotransmitters
- regulate blood flow
Dye coupling occurs in: - Answers - - neurons
- astrocytes
- the presence of gap junctions
Astrocytes: - Answers - - Buffer [K]o
- maintain blood brain barrier
- release certain neurotransmitters
The following cell types are responsible for myelination: - Answers - - Schwann cells
- Oligodendrocytes
The following cells originate in the brain: - Answers - - Astrocytes
- Oligodendrocytes
Study Guide Questions: Lectures 12-13 - Answers -
Sympathetic input to the heart releases _______, which activates the ________,
resulting in dissociation of _______ and increased activity of _______. - Answers -
A,B,C,D - (norepinephrine, beta-adrenergic receptor, Gs, adenylyl cyclase)
The _____ nicotinic receptor increases _______ conductance directly, whereas the
________ muscarinic receptor increases ________ conductance indirectly. - Answers -
A,B,C,D- (ionotropic, sodium, metabotropic, GIRK channel)
G protein inhibition of N-type Ca channels in sympathetic neurons occurs through direct
binding of ______ to the channel: - Answers - the βγ subunit
ANSWERS
Quantum Content is ___________________, while quantal size is
________________________. - Answers - the number of quanta in a neurally evoked
synaptic response; the number of transmitter molecules in a quantum.
At negative membrane potentials, the motor endplate current is carried predominantly
by: - Answers - Na
At the vertebrate neuromuscular synapse, EEPC is approximately equal to: - Answers -
ENa-EK
When [Cl]o is replaced by isethionate, glycine application to a lamprey brainstem
neuron leads to: - Answers - increased permeability & no change in input resistance
At hippocampal GABAergic synapses, autoinhibition is mediated by: - Answers -
GABAB receptors & inhibition of presynaptic voltage-gated calcium channels
At hippocampal glutamatergic synapses, where the postsynaptic membrane potential is
-80 mV: - Answers - postsynaptic current is inward,postsynaptic current is sensitive to
CNQX, postsynaptic current flows exclusively through AMPA channels
At the vertebrate neuromuscular junction, stepping the postsynaptic membrane potential
to progressively more positive values results in: - Answers - a decrease in EPC
amplitude, reversal of the EPC from inward to outward at Em more positive than EEPC
The major factors contributing to synaptic delay are: - Answers - the time required for
opening of presynaptic calcium channels, .
the time required for exocytosis to occur
Yoshikami and Kuffler showed quantal size at the neuromuscular junction to be: -
Answers - ~7000
Exocytotic release of neurotransmitter is: - Answers - sensitive to temperature, sensitive
to calcium, and enhanced in the presence of 4-AP
Miniature end plate potentials (MEPPs): - Answers - are spontaneous events, are
quantal events.
Gap junctions - Answers - .
are cytoplasmic bridges, occur at electrical synapses
, The "kiss and run" mode of transmitter release - Answers - results in partial release of
neurotransmitter from the vesicle, occurs via a "fusion pore"
IPSPs - Answers - are hyperpolarizing membrane responses, result from an increase in
chloride conductance
The EPP at the vertebrate neuromuscular junction: - Answers - is a passive membrane
response, always exceeds threshold under natural conditions
Glial cells - Answers - - buffer [K]o
- depolarize in response to neuronal activity
- recycle neurotransmitters
Astrocytes: - Answers - - respond to neurotransmitters
- release neurotransmitters
- regulate blood flow
Dye coupling occurs in: - Answers - - neurons
- astrocytes
- the presence of gap junctions
Astrocytes: - Answers - - Buffer [K]o
- maintain blood brain barrier
- release certain neurotransmitters
The following cell types are responsible for myelination: - Answers - - Schwann cells
- Oligodendrocytes
The following cells originate in the brain: - Answers - - Astrocytes
- Oligodendrocytes
Study Guide Questions: Lectures 12-13 - Answers -
Sympathetic input to the heart releases _______, which activates the ________,
resulting in dissociation of _______ and increased activity of _______. - Answers -
A,B,C,D - (norepinephrine, beta-adrenergic receptor, Gs, adenylyl cyclase)
The _____ nicotinic receptor increases _______ conductance directly, whereas the
________ muscarinic receptor increases ________ conductance indirectly. - Answers -
A,B,C,D- (ionotropic, sodium, metabotropic, GIRK channel)
G protein inhibition of N-type Ca channels in sympathetic neurons occurs through direct
binding of ______ to the channel: - Answers - the βγ subunit
