CBNS 120 FINAL QUESTIONS WITH VERIFIED
ANSWERS
Facilitation is a form of "short term synaptic plasticity" that leads to: - Answers -
progressive increase in EPP amplitude
Why does facilitation occur? - Answers - Residual calcium in the nerve terminal
What does synaptic depression result from? - Answers - Depletion of the readily
releasable store of synaptic vesicles
What does synaptic depression lead to? - Answers - Reduction in EPP amplitude
What is short term increase in EPP amplitude? - Answers - Facilitation
What is short term decrease in EPP amplitude? - Answers - Synaptic depression
What is long term increase in EPSP amplitude? - Answers - LTP
What is long term decrease in EPSP amplitude? - Answers - LTD
What is essential for induction of LTP1: - Answers - NMDA receptors and ryanodine
receptors
What does the induction of LTP3 require? - Answers - phosphorylation of CREB and
voltage gated calcium channels
synaptic depression may result from: - Answers - ca/calmodulin binding to the IM and
CBD motifs of the calcium channel
Induction of hippocampal LTD involved: - Answers - -activation of phosphatases
-prolonged low level increase of calcium in the postsynaptic cell
-reduction of postsynaptic AMPA receptor density
What are the critical components of cerebellar LTD? - Answers - metabotropic
glutamate receptors
In Aplysia, long term sensitisation: - Answers - -involves new gene expression
-depends on activation of CREB
-involves formation of new synapses
Inhibitors of CAMKII: - Answers - block LTP1
ANSWERS
Facilitation is a form of "short term synaptic plasticity" that leads to: - Answers -
progressive increase in EPP amplitude
Why does facilitation occur? - Answers - Residual calcium in the nerve terminal
What does synaptic depression result from? - Answers - Depletion of the readily
releasable store of synaptic vesicles
What does synaptic depression lead to? - Answers - Reduction in EPP amplitude
What is short term increase in EPP amplitude? - Answers - Facilitation
What is short term decrease in EPP amplitude? - Answers - Synaptic depression
What is long term increase in EPSP amplitude? - Answers - LTP
What is long term decrease in EPSP amplitude? - Answers - LTD
What is essential for induction of LTP1: - Answers - NMDA receptors and ryanodine
receptors
What does the induction of LTP3 require? - Answers - phosphorylation of CREB and
voltage gated calcium channels
synaptic depression may result from: - Answers - ca/calmodulin binding to the IM and
CBD motifs of the calcium channel
Induction of hippocampal LTD involved: - Answers - -activation of phosphatases
-prolonged low level increase of calcium in the postsynaptic cell
-reduction of postsynaptic AMPA receptor density
What are the critical components of cerebellar LTD? - Answers - metabotropic
glutamate receptors
In Aplysia, long term sensitisation: - Answers - -involves new gene expression
-depends on activation of CREB
-involves formation of new synapses
Inhibitors of CAMKII: - Answers - block LTP1
