CBNS 120 9-13 QUESTIONS WITH VERIFIED
ANSWERS
Sympathetic input to the heart releases _______, which activates the ________,
resulting in dissociation of _______ and increased activity of _______. - Answers -
A,B,C,D - (norepinephrine, beta-adrenergic receptor, Gs, adenylyl cyclase)
The _____ nicotinic receptor increases _______ conductance directly, whereas the
________ muscarinic receptor increases ________ conductance indirectly. - Answers -
A,B,C,D- (ionotropic, sodium, metabotropic, GIRK channel)
G protein inhibition of N-type Ca channels in sympathetic neurons occurs through direct
binding of ______ to the channel: - Answers - C- the By(beta gamma) subunit
The following are endocannabinoids: - Answers - E- A & C only (anandamide & 2-AG)
Cardio acceleration by norepinephrine involves synthesis of _______, which binds to
the _______. leading to a shift in its _______ to more _________ potentials. - Answers
- A,B,C,D- (cAMP, HCN channel, voltage-dependent activation, positive)
Activation of Gs leads to elevated levels of _____, while activation of Gi shifts voltage-
dependent activation of the _____ in the negative direction. Gq activation causes
activation of ______, while activation of Go places voltage-dependent calcium channels
in a ______. - Answers - A,B,C,D- (cAMP, HCN channel, phospholipase C(PLC),
reluctant state)
The minutes-long slow EPSP observed in sympathetic ganglion neurons results from -
Answers - D- all of the above (reduced probability of M-channel opening, reduced
membrane conductance, dissociation of PIP2 from the M-channel)
Which of the following shift the voltage-dependent activation curve of HCN in cardiac
pacemaker cells from blue to green? - Answers - C- acetylcholine
Acetylcholine action on endothelial cells activates the _____ leading synthesis of
_________ and activation of ______ in the adjacent smooth muscle cell, leading to
___________. - Answers - A,B,C,D- (mAChR, No, guanylyl cyclase, vasodilation)
Which of the following shift the voltage-dependent activation curve of HCN from blue to
orange? - Answers - A- cAMP
Vagal nerve mediated parasympathetic input to the heart causes: - Answers - E- B & C
only (slowing of heartbeat, reduction of cAMP)
ANSWERS
Sympathetic input to the heart releases _______, which activates the ________,
resulting in dissociation of _______ and increased activity of _______. - Answers -
A,B,C,D - (norepinephrine, beta-adrenergic receptor, Gs, adenylyl cyclase)
The _____ nicotinic receptor increases _______ conductance directly, whereas the
________ muscarinic receptor increases ________ conductance indirectly. - Answers -
A,B,C,D- (ionotropic, sodium, metabotropic, GIRK channel)
G protein inhibition of N-type Ca channels in sympathetic neurons occurs through direct
binding of ______ to the channel: - Answers - C- the By(beta gamma) subunit
The following are endocannabinoids: - Answers - E- A & C only (anandamide & 2-AG)
Cardio acceleration by norepinephrine involves synthesis of _______, which binds to
the _______. leading to a shift in its _______ to more _________ potentials. - Answers
- A,B,C,D- (cAMP, HCN channel, voltage-dependent activation, positive)
Activation of Gs leads to elevated levels of _____, while activation of Gi shifts voltage-
dependent activation of the _____ in the negative direction. Gq activation causes
activation of ______, while activation of Go places voltage-dependent calcium channels
in a ______. - Answers - A,B,C,D- (cAMP, HCN channel, phospholipase C(PLC),
reluctant state)
The minutes-long slow EPSP observed in sympathetic ganglion neurons results from -
Answers - D- all of the above (reduced probability of M-channel opening, reduced
membrane conductance, dissociation of PIP2 from the M-channel)
Which of the following shift the voltage-dependent activation curve of HCN in cardiac
pacemaker cells from blue to green? - Answers - C- acetylcholine
Acetylcholine action on endothelial cells activates the _____ leading synthesis of
_________ and activation of ______ in the adjacent smooth muscle cell, leading to
___________. - Answers - A,B,C,D- (mAChR, No, guanylyl cyclase, vasodilation)
Which of the following shift the voltage-dependent activation curve of HCN from blue to
orange? - Answers - A- cAMP
Vagal nerve mediated parasympathetic input to the heart causes: - Answers - E- B & C
only (slowing of heartbeat, reduction of cAMP)
