TEST BANK
PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE: A
PRACTICAL APPROACH
,Table Of Contents
Foundations Of Pharmacotherapeutics
1. Issues For The Practitioner In Drug Therapy
2. Pharmacokinetic Basis Of Therapeutics And Pharmacodynamic Principles
3. Impact Of Drug Interactions And Adverse Events On Therapeutics
4. Principles Of Pharmacotherapy In Pediatrics, Pregnancy, And Lactation
5. Pharmacotherapy Principles In Older Adults
6. Principles Of Antimicrobial Therapy
7. Pharmacogenomics
8. The Economics Of Pharmacotherapeutics
Pain Management And Dermatologic Disorders
9. Pharmacotherapy Of Pain Management
10. Pain Management In Opioid Use Disorder (Oud) Patients
11. Cannabis And Pain Management
12. Contact Dermatitis
13. Fungal, Viral, And Bacterial Infections Of The Skin
14. Psoriasis
15. Acne Vulgaris And Rosacea
Eye, Ear, And Cardiovascular Disorders
16. Ophthalmic Disorders
17. Otitis Media And Otitis Externa
18. Hypertension
19. Hyperlipidemia
20. Chronic Stable Angina And Myocardial Infarction
21. Heart Failure
22. Arrhythmias
Respiratory And Gastrointestinal Disorders
23. Respiratory Infections
24. Asthma And Chronic Obstructive Pulmonary Disease (Copd)
25. Gastric, Functional, And Inflammatory Bowel Disorders
26. Gastroesophageal Reflux Disease And Peptic Ulcer Disease
27. Liver Diseases
Genitourinary And Reproductive Health
28. Urinary Tract Infection
29. Prostatic Disorders And Erectile Dysfunction
30. Overactive Bladder
31. Sexually Transmitted Infections
Musculoskeletal And Neurologic Disorders
32. Osteoarthritis And Gout
33. Osteoporosis
, 34. Rheumatoid Arthritis
35. Headaches
36. Seizure Disorders
37. Alzheimer's Disease
38. Parkinson's Disease
Mental Health And Behavioral Disorders
39. Major Depressive Disorder And Bipolar Disorders
40. Anxiety Disorders
41. Sleep Disorders
42. Attention-Deficit/Hyperactivity Disorder (Adhd)
43. Substance Use Disorders
Endocrine And Immune Disorders
44. Diabetes Mellitus
45. Thyroid And Parathyroid Disorders
46. Allergies And Allergic Reactions
47. Human Immunodeficiency Virus (Hiv)
48. Organ Transplantation
Hematologic And Preventive Care
49. Thromboembolic Disorders
50. Anemias
51. Immunizations
52. Smoking Cessation
53. Weight Loss
Women's Health
54. Contraception
55. Menopause
56. Vaginitis
This Test Bank Provides Comprehensive Coverage Of All 56 Chapters, Making It A
Valuable Resource For Course Preparation, Assessment Development, And Student
Evaluation In Advanced Pharmacotherapeutics And Advanced Practice Nursing
Education.
, lOMoAR cPSD| 21007614
Lomoar Cpsd| 21007614
Chapter One
1. Nurse Practitioner Prescriptive Authority Is Regulated By:
A. The National Council Of State Boards Of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board Of Nursing For Each State
D. The State Board Of Pharmacy
Answer: C Pts: 1
2. Physician Assistant (Pa) Prescriptive Authority Is Regulated By:
A. The National Council Of State Boards Of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board Of Nursing
D. The State Board Of Medical Examiners
Answer: D Pts: 1
3. Clinical Judgment In Prescribing Includes:
A. Factoring In The Cost To The Patient Of The Medication Prescribed
B. Always Prescribing The Newest Medication Available For The Disease Process
C. Handing Out Drug Samples To Poor Patients
D. Prescribing All Generic Medications To Cut Costs
Answer: A Pts: 1
4. Criteria For Choosing An Effective Drug For A Disorder Include:
A. Asking The Patient What Drug They Think Would Work Best For Them
B. Consulting Nationally Recognized Guidelines For Disease Management
C. Prescribing Medications That Are Available As Samples Before Writing A Prescription
D. Following U.S. Drug Enforcement Administration (Dea) Guidelines For
Prescribing
Answer: B Pts: 1
5. Nurse Practitioner Practice May Thrive Under Health-Care Reform Due To:
A. The Demonstrated Ability Of Nurse Practitioners To Control Costs And Improve
Patient Outcomes
B. The Fact That Nurse Practitioners Will Be Able To Practice Independently
C. The Fact That Nurse Practitioners Will Have Full Reimbursement Under
Health-Care Reform
D. The Ability To Shift Accountability For Medicaid To The State Level
Answer: A Pts: 1
, lOMoAR cPSD| 21007614
Chapter 2.Pharmacokinetic Basis Of Therapeutics And Pharmacodynamic
Multiple Choice
1. A Patient's Nutritional Intake And Lab Work Reflects Hypoalbuminemia. This Is
Critical To Prescribing Because:
A. Distribution Of Drugs To Target Tissue May Be Affected
B. The Solubility Of The Drug Will Not Match The Site Of Absorption
C. There Will Be Less Free Drug Available To Generate An Effect
D. Drugs Bound To Albumin Are Readily Excreted By The Kidney
Answer: A Pts: 1
2. Drugs That Have A Significant First-Pass Effect:
A. Must Be Given By The Enteral (Oral) Route Only
B. Bypass The Hepatic Circulation
C. Are Rapidly Metabolized By The Liver And May Have Little If Any Desired Action
D. Are Converted By The Liver To More Active And Fat-Soluble Forms
Answer: C Pts: 1
3. The Route Of Excretion Of A Volatile Drug Will Likely Be:
A. The Kidneys
B. The Lungs
C. The Bile And Feces
D. The Skin
Answer: B Pts: 1
4. Medroxyprogesterone (Depo Provera) Is Prescribed Im To Create A Storage Reservoir Of
The Drug. Storage Reservoirs:
A. Assure That The Drug Will Reach Its Intended Target Tissue
B. Are The Reason For Giving Loading Doses
C. Increase The Length Of Time A Drug Is Available And Active
D. Are Most Common In Collagen Tissues
Answer: C Pts: 1
5. The Np Chooses To Give Cephalexin Every 8 Hours Based On Knowledge Of The Drug's:
A. Propensity To Go To The Target Receptor
B. Biological Half-Life
C. Pharmacodynamics
D. Safety And Side Effects
Answer: B Pts: 1
6. Azithromycin Dosing Requires The First Day's Dose Be Twice Those Of The Other 4
Days Of The Prescription. This Is Considered A Loading Dose. A Loading Dose:
A. Rapidly Achieves Drug Levels In The Therapeutic Range
B. Requires Four To Five Half-Lives To Attain
C. Is Influenced By Renal Function
, lOMoAR cPSD| 21007614
D. Is Directly Related To The Drug Circulating To The Target Tissues
Answer: A Pts: 1
7. The Point In Time On The Drug Concentration Curve That Indicates The First
Sign Of A Therapeutic Effect Is The:
A. Minimum Adverse Effect Level
B. Peak Of Action
C. Onset Of Action
D. Therapeutic Range
Answer: C Pts: 1
8. Phenytoin Requires A Trough Level Be Drawn. Peak And Trough Levels Are Done:
A. When The Drug Has A Wide Therapeutic Range
B. When The Drug Will Be Administered For A Short Time Only
C. When There Is A High Correlation Between The Dose And Saturation Of Receptor Sites
D. To Determine If A Drug Is In The Therapeutic Range
Answer: D Pts: 1
9. A Laboratory Result Indicates The Peak Level For A Drug Is Above The
Minimum Toxic Concentration. This Means That The:
A. Concentration Will Produce Therapeutic Effects
B. Concentration Will Produce An Adverse Response
C. Time Between Doses Must Be Shortened
D. Duration Of Action Of The Drug Is Too Long
Answer: B Pts: 1
10. Drugs That Are Receptor Agonists May Demonstrate What Property?
A. Irreversible Binding To The Drug Receptor Site
B. Up-Regulation With Chronic Use
C. Desensitization Or Down-Regulation With Continuous Use
D. Inverse Relationship Between Drug Concentration And Drug Action
Answer: C Pts: 1
11. Drugs That Are Receptor Antagonists, Such As Beta Blockers, May Cause:
A. Down-Regulation Of The Drug Receptor
B. An Exaggerated Response If Abruptly Discontinued
C. Partial Blockade Of The Effects Of Agonist Drugs
D. An Exaggerated Response To Competitive Drug Agonists
Answer: B Pts: 1
12. Factors That Affect Gastric Drug Absorption Include:
A. Liver Enzyme Activity
B. Protein-Binding Properties Of The Drug Molecule
C. Lipid Solubility Of The Drug
D. Ability To Chew And Swallow
Answer: C Pts: 1
, lOMoAR cPSD| 21007614
13. Drugs Administered Via Intravenous (Iv) Route:
A. Need To Be Lipid Soluble In Order To Be Easily Absorbed
B. Begin Distribution Into The Body Immediately
C. Are Easily Absorbed If They Are Nonionized
D. May Use Pinocytosis To Be Absorbed
Answer: B Pts: 1
14. When A Medication Is Added To A Regimen For A Synergistic Effect, The
Combined Effect Of The Drugs Is:
A.The Sum Of The Effects Of Each Drug Individually
B.Greater Than The Sum Of The Effects Of Each Drug Individually
C.Less Than The Effect Of Each Drug Individually
D.Not Predictable, As It Varies With Each Individual
Answer: B Pts: 1
15. Which Of The Following Statements About Bioavailability Is True?
A. Bioavailability Issues Are Especially Important For Drugs With
Narrow Therapeutic Ranges Or Sustained Release Mechanisms.
B. All Brands Of A Drug Have The Same Bioavailability.
C. Drugs That Are Administered More Than Once A Day Have Greater
Bioavailability Than Drugs Given Once Daily.
D. Combining An Active Drug With An Inert Substance Does Not Affect Bioavailability.
Answer: A Pts: 1
16. Which Of The Following Statements About The Major Distribution Barriers
(Blood-Brain Or Fetal-Placental) Is True?
A. Water Soluble And Ionized Drugs Cross These Barriers Rapidly.
B. The Blood-Brain Barrier Slows The Entry Of Many Drugs Into And From Brain Cells.
C. The Fetal-Placental Barrier Protects The Fetus From Drugs Taken By The Mother.
D. Lipid Soluble Drugs Do Not Pass These Barriers And Are Safe For Pregnant Women.
Answer: B Pts: 1
17. Drugs Are Metabolized Mainly By The Liver Via Phase I Or Phase Ii Reactions.
The Purpose Of Both Of These Types Of Reactions Is To:
A. Inactivate Prodrugs Before They Can Be Activated By Target Tissues
B. Change The Drugs So They Can Cross Plasma Membranes
C. Change Drug Molecules To A Form That An Excretory Organ Can Excrete
D. Make These Drugs More Ionized And Polar To Facilitate Excretion
Answer: C Pts: 1
18. Once They Have Been Metabolized By The Liver, The Metabolites May Be:
A. More Active Than The Parent Drug
B. Less Active Than The Parent Drug
C. Totally “Deactivated” So That They Are Excreted Without Any Effect
D. All Of The Above
Answer: D Pts: 1
, lOMoAR cPSD| 21007614
19. All Drugs Continue To Act In The Body Until They Are Changed Or Excreted. The
Ability Of The Body To Excrete Drugs Via The Renal System Would Be
Increased By:
A. Reduced Circulation And Perfusion Of The Kidney
B. Chronic Renal Disease
C. Competition For A Transport Site By Another Drug
D. Unbinding A Nonvolatile Drug From Plasma Proteins
Answer: D Pts: 1
20. Steady State Is:
A. The Point On The Drug Concentration Curve When Absorption Exceeds Excretion
B. When The Amount Of Drug In The Body Remains Constant
C. When The Amount Of Drug In The Body Stays Below The Mtc
D. All Of The Above
Answer: B Pts: 1
21. Two Different Pain Meds Are Given Together For Pain Relief. The Drug-Drug Interaction
Is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
Answer: D Pts: 1
22. Actions Taken To Reduce Drug-Drug Interaction Problems Include All
Of The Following Except:
A. Reducing The Dose Of One Of The Drugs
B. Scheduling Their Administration At Different Times
C. Prescribing A Third Drug To Counteract The Adverse Reaction Of The Combination
D. Reducing The Dosage Of Both Drugs
Answer: C Pts: 1
23. Phase I Oxidative-Reductive Processes Of Drug Metabolism Require Certain
Nutritional Elements. Which Of The Following Would Reduce Or Inhibit This
Process?
A. Protein Malnutrition
B. Iron Deficiency Anemia
C. Both A And B
D. Neither A Nor B
Answer: D Pts: 1
24. The Time Required For The Amount Of Drug In The Body To Decrease By 50% Is Called:
A. Steady State
B. Half-Life
C. Phase Ii Metabolism
D. Reduced Bioavailability Time
Answer: B Pts: 1
, lOMoAR cPSD| 21007614
25. An Agonist Activates A Receptor And Stimulates A Response. When Given
Frequently Over Time The Body May:
A. Up-Regulate The Total Number Of Receptors
B. Block The Receptor With A Partial Agonist
C. Alter The Drug's Metabolism
D. Down-Regulate The Numbers Of That Specific Receptor
Answer: D Pts: 1
26. Drug Antagonism Is Best Defined As An Effect Of A
Drug
That:
A. Leads To Major Physiologic Psychological Dependence
B. Is Modified By The Concurrent Administration Of Another Drug
C. Cannot Be Metabolized Before Another Dose Is Administered
D. Leads To A Decreased Physiologic Response When Combined With Another Drug
Answer: B Pts: 1
27. Instructions To A Client Regarding Self-Administration Of Oral Enteric-Coated
Tablets Should Include Which Of The Following Statements?
A. “Avoid Any Other Oral Medicines While Taking This Drug.”
B. “If Swallowing This Tablet Is Difficult, Dissolve It In 3 Ounces Of Orange Juice.”
C. “The Tablet May Be Crushed If You Have Any Difficultly Taking It.”
D. “To Achieve Best Effect, Take The Tablet With At Least 8 Ounces Of Fluid.”
Answer: D Pts: 1
28. The Major Reason For Not Crushing A Sustained Release Capsule Is That, If
Crushed, The Coated Beads Of The Drugs Could Possibly Result In:
A. Disintegration
B. Toxicity
C. Malabsorption
D. Deterioration
Answer: B Pts: 1
29. Which Of The Following Substances Is The Most Likely To Be Absorbed In The
Intestines Rather Than In The Stomach?
A. Sodium Bicarbonate
B. Ascorbic Acid
C. Salicylic Acid
D. Glucose
Answer: A Pts: 1
30. Which Of The Following Variables Is A Factor In Drug Absorption?
A. The Smaller The Surface Area For Absorption, The More Rapidly The Drug Is Absorbed.
B. A Rich Blood Supply To The Area Of Absorption Leads To Better Absorption.
C. The Less Soluble The Drug, The More Easily It Is Absorbed.
D. Ionized Drugs Are Easily Absorbed Across The Cell Membrane.
Answer: B Pts: 1
31. An Advantage Of Prescribing A Sublingual Medication Is That The Medication Is:
, lOMoAR cPSD| 21007614
A. Absorbed Rapidly
B. Excreted Rapidly
C. Metabolized Minimally
D. Distributed Equally
Answer: A Pts: 1
32. Drugs That Use Cyp 3a4 Isoenzymes For Metabolism May:
A. Induce The Metabolism Of Another Drug
B. Inhibit The Metabolism Of Another Drug
C. Both A And B
D. Neither A Nor B
Answer: C Pts: 1
33. Therapeutic Drug Levels Are Drawn When A Drug Reaches Steady State. Drugs Reach
Steady State:
A. After The Second Dose
B. After Four To Five Half-Lives
C. When The Patient Feels The Full Effect Of The Drug
D. One Hour After Iv Administration
Answer: B Pts: 1
34. Up-Regulation Or Hypersensitization May Lead To:
A. Increased Response To A Drug
B. Decreased Response To A Drug
C. An Exaggerated Response If The Drug Sis Swithdrawn
D. Refractoriness Or Complete Lack Sof Sresponse
Answer: C Pts: 1
PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE: A
PRACTICAL APPROACH
,Table Of Contents
Foundations Of Pharmacotherapeutics
1. Issues For The Practitioner In Drug Therapy
2. Pharmacokinetic Basis Of Therapeutics And Pharmacodynamic Principles
3. Impact Of Drug Interactions And Adverse Events On Therapeutics
4. Principles Of Pharmacotherapy In Pediatrics, Pregnancy, And Lactation
5. Pharmacotherapy Principles In Older Adults
6. Principles Of Antimicrobial Therapy
7. Pharmacogenomics
8. The Economics Of Pharmacotherapeutics
Pain Management And Dermatologic Disorders
9. Pharmacotherapy Of Pain Management
10. Pain Management In Opioid Use Disorder (Oud) Patients
11. Cannabis And Pain Management
12. Contact Dermatitis
13. Fungal, Viral, And Bacterial Infections Of The Skin
14. Psoriasis
15. Acne Vulgaris And Rosacea
Eye, Ear, And Cardiovascular Disorders
16. Ophthalmic Disorders
17. Otitis Media And Otitis Externa
18. Hypertension
19. Hyperlipidemia
20. Chronic Stable Angina And Myocardial Infarction
21. Heart Failure
22. Arrhythmias
Respiratory And Gastrointestinal Disorders
23. Respiratory Infections
24. Asthma And Chronic Obstructive Pulmonary Disease (Copd)
25. Gastric, Functional, And Inflammatory Bowel Disorders
26. Gastroesophageal Reflux Disease And Peptic Ulcer Disease
27. Liver Diseases
Genitourinary And Reproductive Health
28. Urinary Tract Infection
29. Prostatic Disorders And Erectile Dysfunction
30. Overactive Bladder
31. Sexually Transmitted Infections
Musculoskeletal And Neurologic Disorders
32. Osteoarthritis And Gout
33. Osteoporosis
, 34. Rheumatoid Arthritis
35. Headaches
36. Seizure Disorders
37. Alzheimer's Disease
38. Parkinson's Disease
Mental Health And Behavioral Disorders
39. Major Depressive Disorder And Bipolar Disorders
40. Anxiety Disorders
41. Sleep Disorders
42. Attention-Deficit/Hyperactivity Disorder (Adhd)
43. Substance Use Disorders
Endocrine And Immune Disorders
44. Diabetes Mellitus
45. Thyroid And Parathyroid Disorders
46. Allergies And Allergic Reactions
47. Human Immunodeficiency Virus (Hiv)
48. Organ Transplantation
Hematologic And Preventive Care
49. Thromboembolic Disorders
50. Anemias
51. Immunizations
52. Smoking Cessation
53. Weight Loss
Women's Health
54. Contraception
55. Menopause
56. Vaginitis
This Test Bank Provides Comprehensive Coverage Of All 56 Chapters, Making It A
Valuable Resource For Course Preparation, Assessment Development, And Student
Evaluation In Advanced Pharmacotherapeutics And Advanced Practice Nursing
Education.
, lOMoAR cPSD| 21007614
Lomoar Cpsd| 21007614
Chapter One
1. Nurse Practitioner Prescriptive Authority Is Regulated By:
A. The National Council Of State Boards Of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board Of Nursing For Each State
D. The State Board Of Pharmacy
Answer: C Pts: 1
2. Physician Assistant (Pa) Prescriptive Authority Is Regulated By:
A. The National Council Of State Boards Of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board Of Nursing
D. The State Board Of Medical Examiners
Answer: D Pts: 1
3. Clinical Judgment In Prescribing Includes:
A. Factoring In The Cost To The Patient Of The Medication Prescribed
B. Always Prescribing The Newest Medication Available For The Disease Process
C. Handing Out Drug Samples To Poor Patients
D. Prescribing All Generic Medications To Cut Costs
Answer: A Pts: 1
4. Criteria For Choosing An Effective Drug For A Disorder Include:
A. Asking The Patient What Drug They Think Would Work Best For Them
B. Consulting Nationally Recognized Guidelines For Disease Management
C. Prescribing Medications That Are Available As Samples Before Writing A Prescription
D. Following U.S. Drug Enforcement Administration (Dea) Guidelines For
Prescribing
Answer: B Pts: 1
5. Nurse Practitioner Practice May Thrive Under Health-Care Reform Due To:
A. The Demonstrated Ability Of Nurse Practitioners To Control Costs And Improve
Patient Outcomes
B. The Fact That Nurse Practitioners Will Be Able To Practice Independently
C. The Fact That Nurse Practitioners Will Have Full Reimbursement Under
Health-Care Reform
D. The Ability To Shift Accountability For Medicaid To The State Level
Answer: A Pts: 1
, lOMoAR cPSD| 21007614
Chapter 2.Pharmacokinetic Basis Of Therapeutics And Pharmacodynamic
Multiple Choice
1. A Patient's Nutritional Intake And Lab Work Reflects Hypoalbuminemia. This Is
Critical To Prescribing Because:
A. Distribution Of Drugs To Target Tissue May Be Affected
B. The Solubility Of The Drug Will Not Match The Site Of Absorption
C. There Will Be Less Free Drug Available To Generate An Effect
D. Drugs Bound To Albumin Are Readily Excreted By The Kidney
Answer: A Pts: 1
2. Drugs That Have A Significant First-Pass Effect:
A. Must Be Given By The Enteral (Oral) Route Only
B. Bypass The Hepatic Circulation
C. Are Rapidly Metabolized By The Liver And May Have Little If Any Desired Action
D. Are Converted By The Liver To More Active And Fat-Soluble Forms
Answer: C Pts: 1
3. The Route Of Excretion Of A Volatile Drug Will Likely Be:
A. The Kidneys
B. The Lungs
C. The Bile And Feces
D. The Skin
Answer: B Pts: 1
4. Medroxyprogesterone (Depo Provera) Is Prescribed Im To Create A Storage Reservoir Of
The Drug. Storage Reservoirs:
A. Assure That The Drug Will Reach Its Intended Target Tissue
B. Are The Reason For Giving Loading Doses
C. Increase The Length Of Time A Drug Is Available And Active
D. Are Most Common In Collagen Tissues
Answer: C Pts: 1
5. The Np Chooses To Give Cephalexin Every 8 Hours Based On Knowledge Of The Drug's:
A. Propensity To Go To The Target Receptor
B. Biological Half-Life
C. Pharmacodynamics
D. Safety And Side Effects
Answer: B Pts: 1
6. Azithromycin Dosing Requires The First Day's Dose Be Twice Those Of The Other 4
Days Of The Prescription. This Is Considered A Loading Dose. A Loading Dose:
A. Rapidly Achieves Drug Levels In The Therapeutic Range
B. Requires Four To Five Half-Lives To Attain
C. Is Influenced By Renal Function
, lOMoAR cPSD| 21007614
D. Is Directly Related To The Drug Circulating To The Target Tissues
Answer: A Pts: 1
7. The Point In Time On The Drug Concentration Curve That Indicates The First
Sign Of A Therapeutic Effect Is The:
A. Minimum Adverse Effect Level
B. Peak Of Action
C. Onset Of Action
D. Therapeutic Range
Answer: C Pts: 1
8. Phenytoin Requires A Trough Level Be Drawn. Peak And Trough Levels Are Done:
A. When The Drug Has A Wide Therapeutic Range
B. When The Drug Will Be Administered For A Short Time Only
C. When There Is A High Correlation Between The Dose And Saturation Of Receptor Sites
D. To Determine If A Drug Is In The Therapeutic Range
Answer: D Pts: 1
9. A Laboratory Result Indicates The Peak Level For A Drug Is Above The
Minimum Toxic Concentration. This Means That The:
A. Concentration Will Produce Therapeutic Effects
B. Concentration Will Produce An Adverse Response
C. Time Between Doses Must Be Shortened
D. Duration Of Action Of The Drug Is Too Long
Answer: B Pts: 1
10. Drugs That Are Receptor Agonists May Demonstrate What Property?
A. Irreversible Binding To The Drug Receptor Site
B. Up-Regulation With Chronic Use
C. Desensitization Or Down-Regulation With Continuous Use
D. Inverse Relationship Between Drug Concentration And Drug Action
Answer: C Pts: 1
11. Drugs That Are Receptor Antagonists, Such As Beta Blockers, May Cause:
A. Down-Regulation Of The Drug Receptor
B. An Exaggerated Response If Abruptly Discontinued
C. Partial Blockade Of The Effects Of Agonist Drugs
D. An Exaggerated Response To Competitive Drug Agonists
Answer: B Pts: 1
12. Factors That Affect Gastric Drug Absorption Include:
A. Liver Enzyme Activity
B. Protein-Binding Properties Of The Drug Molecule
C. Lipid Solubility Of The Drug
D. Ability To Chew And Swallow
Answer: C Pts: 1
, lOMoAR cPSD| 21007614
13. Drugs Administered Via Intravenous (Iv) Route:
A. Need To Be Lipid Soluble In Order To Be Easily Absorbed
B. Begin Distribution Into The Body Immediately
C. Are Easily Absorbed If They Are Nonionized
D. May Use Pinocytosis To Be Absorbed
Answer: B Pts: 1
14. When A Medication Is Added To A Regimen For A Synergistic Effect, The
Combined Effect Of The Drugs Is:
A.The Sum Of The Effects Of Each Drug Individually
B.Greater Than The Sum Of The Effects Of Each Drug Individually
C.Less Than The Effect Of Each Drug Individually
D.Not Predictable, As It Varies With Each Individual
Answer: B Pts: 1
15. Which Of The Following Statements About Bioavailability Is True?
A. Bioavailability Issues Are Especially Important For Drugs With
Narrow Therapeutic Ranges Or Sustained Release Mechanisms.
B. All Brands Of A Drug Have The Same Bioavailability.
C. Drugs That Are Administered More Than Once A Day Have Greater
Bioavailability Than Drugs Given Once Daily.
D. Combining An Active Drug With An Inert Substance Does Not Affect Bioavailability.
Answer: A Pts: 1
16. Which Of The Following Statements About The Major Distribution Barriers
(Blood-Brain Or Fetal-Placental) Is True?
A. Water Soluble And Ionized Drugs Cross These Barriers Rapidly.
B. The Blood-Brain Barrier Slows The Entry Of Many Drugs Into And From Brain Cells.
C. The Fetal-Placental Barrier Protects The Fetus From Drugs Taken By The Mother.
D. Lipid Soluble Drugs Do Not Pass These Barriers And Are Safe For Pregnant Women.
Answer: B Pts: 1
17. Drugs Are Metabolized Mainly By The Liver Via Phase I Or Phase Ii Reactions.
The Purpose Of Both Of These Types Of Reactions Is To:
A. Inactivate Prodrugs Before They Can Be Activated By Target Tissues
B. Change The Drugs So They Can Cross Plasma Membranes
C. Change Drug Molecules To A Form That An Excretory Organ Can Excrete
D. Make These Drugs More Ionized And Polar To Facilitate Excretion
Answer: C Pts: 1
18. Once They Have Been Metabolized By The Liver, The Metabolites May Be:
A. More Active Than The Parent Drug
B. Less Active Than The Parent Drug
C. Totally “Deactivated” So That They Are Excreted Without Any Effect
D. All Of The Above
Answer: D Pts: 1
, lOMoAR cPSD| 21007614
19. All Drugs Continue To Act In The Body Until They Are Changed Or Excreted. The
Ability Of The Body To Excrete Drugs Via The Renal System Would Be
Increased By:
A. Reduced Circulation And Perfusion Of The Kidney
B. Chronic Renal Disease
C. Competition For A Transport Site By Another Drug
D. Unbinding A Nonvolatile Drug From Plasma Proteins
Answer: D Pts: 1
20. Steady State Is:
A. The Point On The Drug Concentration Curve When Absorption Exceeds Excretion
B. When The Amount Of Drug In The Body Remains Constant
C. When The Amount Of Drug In The Body Stays Below The Mtc
D. All Of The Above
Answer: B Pts: 1
21. Two Different Pain Meds Are Given Together For Pain Relief. The Drug-Drug Interaction
Is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
Answer: D Pts: 1
22. Actions Taken To Reduce Drug-Drug Interaction Problems Include All
Of The Following Except:
A. Reducing The Dose Of One Of The Drugs
B. Scheduling Their Administration At Different Times
C. Prescribing A Third Drug To Counteract The Adverse Reaction Of The Combination
D. Reducing The Dosage Of Both Drugs
Answer: C Pts: 1
23. Phase I Oxidative-Reductive Processes Of Drug Metabolism Require Certain
Nutritional Elements. Which Of The Following Would Reduce Or Inhibit This
Process?
A. Protein Malnutrition
B. Iron Deficiency Anemia
C. Both A And B
D. Neither A Nor B
Answer: D Pts: 1
24. The Time Required For The Amount Of Drug In The Body To Decrease By 50% Is Called:
A. Steady State
B. Half-Life
C. Phase Ii Metabolism
D. Reduced Bioavailability Time
Answer: B Pts: 1
, lOMoAR cPSD| 21007614
25. An Agonist Activates A Receptor And Stimulates A Response. When Given
Frequently Over Time The Body May:
A. Up-Regulate The Total Number Of Receptors
B. Block The Receptor With A Partial Agonist
C. Alter The Drug's Metabolism
D. Down-Regulate The Numbers Of That Specific Receptor
Answer: D Pts: 1
26. Drug Antagonism Is Best Defined As An Effect Of A
Drug
That:
A. Leads To Major Physiologic Psychological Dependence
B. Is Modified By The Concurrent Administration Of Another Drug
C. Cannot Be Metabolized Before Another Dose Is Administered
D. Leads To A Decreased Physiologic Response When Combined With Another Drug
Answer: B Pts: 1
27. Instructions To A Client Regarding Self-Administration Of Oral Enteric-Coated
Tablets Should Include Which Of The Following Statements?
A. “Avoid Any Other Oral Medicines While Taking This Drug.”
B. “If Swallowing This Tablet Is Difficult, Dissolve It In 3 Ounces Of Orange Juice.”
C. “The Tablet May Be Crushed If You Have Any Difficultly Taking It.”
D. “To Achieve Best Effect, Take The Tablet With At Least 8 Ounces Of Fluid.”
Answer: D Pts: 1
28. The Major Reason For Not Crushing A Sustained Release Capsule Is That, If
Crushed, The Coated Beads Of The Drugs Could Possibly Result In:
A. Disintegration
B. Toxicity
C. Malabsorption
D. Deterioration
Answer: B Pts: 1
29. Which Of The Following Substances Is The Most Likely To Be Absorbed In The
Intestines Rather Than In The Stomach?
A. Sodium Bicarbonate
B. Ascorbic Acid
C. Salicylic Acid
D. Glucose
Answer: A Pts: 1
30. Which Of The Following Variables Is A Factor In Drug Absorption?
A. The Smaller The Surface Area For Absorption, The More Rapidly The Drug Is Absorbed.
B. A Rich Blood Supply To The Area Of Absorption Leads To Better Absorption.
C. The Less Soluble The Drug, The More Easily It Is Absorbed.
D. Ionized Drugs Are Easily Absorbed Across The Cell Membrane.
Answer: B Pts: 1
31. An Advantage Of Prescribing A Sublingual Medication Is That The Medication Is:
, lOMoAR cPSD| 21007614
A. Absorbed Rapidly
B. Excreted Rapidly
C. Metabolized Minimally
D. Distributed Equally
Answer: A Pts: 1
32. Drugs That Use Cyp 3a4 Isoenzymes For Metabolism May:
A. Induce The Metabolism Of Another Drug
B. Inhibit The Metabolism Of Another Drug
C. Both A And B
D. Neither A Nor B
Answer: C Pts: 1
33. Therapeutic Drug Levels Are Drawn When A Drug Reaches Steady State. Drugs Reach
Steady State:
A. After The Second Dose
B. After Four To Five Half-Lives
C. When The Patient Feels The Full Effect Of The Drug
D. One Hour After Iv Administration
Answer: B Pts: 1
34. Up-Regulation Or Hypersensitization May Lead To:
A. Increased Response To A Drug
B. Decreased Response To A Drug
C. An Exaggerated Response If The Drug Sis Swithdrawn
D. Refractoriness Or Complete Lack Sof Sresponse
Answer: C Pts: 1
