AGNP AANP Study Guide A+ Exam Questions and Answers Verified Solutions Latest Update 2026/2027

AGNP AANP Study Guide A+ Exam
Questions and Answers Verified Solutions
Latest Update 2026/2027

Question:
nigrostriatal pathway.

Answer:
from substantia nigra (brainstem) to striatum (muscles): Parkinson's


Question:
mesolimbic pathway.

Answer:
projects to nucleus accumbens (part of limbic system). Pleasure, reward, positive symptoms of
schizophrenia: Addiction, gambling


Question:
Tuberoinfundibular pathway.

Answer:
regulation of prolactin (acts on pituitary). Hypersexuality in mania


Question:
Dopamine.

Answer:
produced in substania nigra and VTA. D2 & D4 receptors most important. Elevated in the
mesolimbic pathway associated with pleasure and psychosis. Antispychotics block dopamine.
travels through mesocoritcal, mesolimbic, nigrostriatal, and tuberinfundibular pathways

, Question:
Serotonin.

Answer:
5-HT. produced in raphe nucleus. emotion, impulses, dreams. 5HT2A receptors = atypical
antipsychotics.


Question:
Norepinephrine.

Answer:
produced in locus coeruleus. arousal and vigilance


Question:
GABA.

Answer:
inhibitory. produces calm in conjunction with benzodiazepines.


Question:
ACTH.

Answer:
motor control, learning, memory, sleep, and dreams. Helps with balance. Decrease in Alzheimer's
disease


Question:
hypothalamus-pituitary-adrenal axis (HPA).

Answer:
CRH, ACTH, then cortisol. Worsens with stress and depression


Question:
hypothalamus-pituitary-thyroid (HPT).