WGU D027 Practice Exam: 200 Comprehensive
Q&A with Clinical Rationales for Advanced
Pathopharmacological Foundations
Certification Success
WGU D027 Practice Exam: 200 Questions with
☑VERIFIED ANSWERs and Rationales
GENETICS AND GENOMICS
1. A mother brought her child to the doctor for
genetic testing. The health care provider
explains that the child has two X
chromosomes and a Y chromosome in each
cell. He explains that she might notice her son
has sparse body hair, long limbs, and small
testes. Which syndrome is the health care
practitioner explaining?
• a) Turner's syndrome
, • b) Down syndrome
• c) Klinefelter syndrome
• d) Kawasaki's disease
☑VERIFIED ANSWER: c) Klinefelter syndrome
Rationale: Klinefelter syndrome is a
chromosomal condition in males who have an
extra X chromosome (XXY). Physical
characteristics include a tall, thin physique,
small testes, and sparse body hair.
2. A patient has endured several dosage
adjustments of his tricyclic antidepressant, so
the provider recommends genetic testing.
Which statement correctly describes the
rationale for this genetic testing?
• a) The BRCA2 gene influences metabolism
of certain drugs.
, • b) The CYP2D6 gene influences metabolism
of tricyclic antidepressants.
• c) The HER2 gene is a tumor marker that
impacts drug metabolism.
• d) The X-linked OPN1MW gene slows
metabolism of certain drugs.
☑VERIFIED ANSWER: b) The CYP2D6 gene
influences metabolism of tricyclic
antidepressants.
Rationale: The CYP2D6 gene is a key enzyme in
metabolizing many drugs, including tricyclic
antidepressants, beta-blockers, and
antipsychotics. Genetic testing for CYP2D6
variants helps guide dosage decisions to
prevent adverse effects or therapeutic failure.
, 3. A 46-year-old woman is considering having
another child. The healthcare providers
explain that children born to women late in
life have an increased rate of which condition?
• a) Kawasaki's disease
• b) Down syndrome
• c) Klinefelter syndrome
• d) Turner syndrome
☑VERIFIED ANSWER: b) Down syndrome
Rationale: Down syndrome risk increases with
maternal age. The extra chromosome 21
typically arises from nondisjunction during
meiosis in the oocyte, and this risk rises
significantly as women age.
4. A 20-year-old male meets with an APN to
discuss symptoms slowly progressing over
Q&A with Clinical Rationales for Advanced
Pathopharmacological Foundations
Certification Success
WGU D027 Practice Exam: 200 Questions with
☑VERIFIED ANSWERs and Rationales
GENETICS AND GENOMICS
1. A mother brought her child to the doctor for
genetic testing. The health care provider
explains that the child has two X
chromosomes and a Y chromosome in each
cell. He explains that she might notice her son
has sparse body hair, long limbs, and small
testes. Which syndrome is the health care
practitioner explaining?
• a) Turner's syndrome
, • b) Down syndrome
• c) Klinefelter syndrome
• d) Kawasaki's disease
☑VERIFIED ANSWER: c) Klinefelter syndrome
Rationale: Klinefelter syndrome is a
chromosomal condition in males who have an
extra X chromosome (XXY). Physical
characteristics include a tall, thin physique,
small testes, and sparse body hair.
2. A patient has endured several dosage
adjustments of his tricyclic antidepressant, so
the provider recommends genetic testing.
Which statement correctly describes the
rationale for this genetic testing?
• a) The BRCA2 gene influences metabolism
of certain drugs.
, • b) The CYP2D6 gene influences metabolism
of tricyclic antidepressants.
• c) The HER2 gene is a tumor marker that
impacts drug metabolism.
• d) The X-linked OPN1MW gene slows
metabolism of certain drugs.
☑VERIFIED ANSWER: b) The CYP2D6 gene
influences metabolism of tricyclic
antidepressants.
Rationale: The CYP2D6 gene is a key enzyme in
metabolizing many drugs, including tricyclic
antidepressants, beta-blockers, and
antipsychotics. Genetic testing for CYP2D6
variants helps guide dosage decisions to
prevent adverse effects or therapeutic failure.
, 3. A 46-year-old woman is considering having
another child. The healthcare providers
explain that children born to women late in
life have an increased rate of which condition?
• a) Kawasaki's disease
• b) Down syndrome
• c) Klinefelter syndrome
• d) Turner syndrome
☑VERIFIED ANSWER: b) Down syndrome
Rationale: Down syndrome risk increases with
maternal age. The extra chromosome 21
typically arises from nondisjunction during
meiosis in the oocyte, and this risk rises
significantly as women age.
4. A 20-year-old male meets with an APN to
discuss symptoms slowly progressing over
