NAPSRX__Quiz_Chapter_10

The aim of preclinical pharmacological studies is to obtain data on the safety and effectiveness of the lead compound. Toxicity information in preclinical studies helps provide confidence about a drug’s safety. Pharmacological studies using animals are regulated under Good Laboratory Practice. Why do drugs administered to patients only contain APIs? Which of the following does NOT affect a drug’s ability to permeate membranes? Through which barriers can lipid-soluble drugs usually pass? How are weak acid drugs generally absorbed by the stomach? Which of the following routes of administration do NOT completely bypass the liver? Why are intravenous drug dosages easier to control than drugs administered transdermally? Which of the following does NOT affect a drug’s distribution to its target tissues? Which of these medical terms means “to apply the drug on the skin surface”? Carcinogenicity studies are carried out to identify the tumor-causing potential of a drug.