TIETZ FUNDAMENTALS OF CLINICAL
CHEMISTRY AND MOLECULAR
DIAGNOSTICS EIGHTH EDITION NADER
RIFAI CERTIFICATION EVALUATION
EXAMS COMPLETE QUESTIONS AND
VERIFIED SOLUTIONS GRADED A+
⩥ What is the primary role of redundancy in bodily systems during
disease?
Answer: The body uses redundant and complementary systems to
compensate for pathological changes.
⩥ List four categories of analytes measured in chemistry testing.
Answer: Analytes with biological function, nonfunctional
metabolites/waste products, indicators of cell damage/disease, and
drugs/toxic substances.
⩥ What is the most common specimen type used in clinical chemistry?
Answer: Blood (specifically serum, plasma, or whole blood).
⩥ Why is fasting often required for chemistry testing?
Answer: To ensure accurate results for analytes that fluctuate with
meals, such as glucose, triglycerides, and cholesterol.
, ⩥ What are diurnal variations in clinical chemistry?
Answer: Changes in analyte concentrations that occur at different times
of the day, such as with iron or corticosteroids.
⩥ What effect does hemolysis have on chemistry test results?
Answer: It causes increases in hemoglobin, enzymes, and potassium.
⩥ What is the result of failing to remove serum or plasma from cells in a
specimen?
Answer: A decrease in glucose concentration.
⩥ What does an 'icteric' specimen indicate?
Answer: The presence of excessive bilirubin.
⩥ How is a reference range typically calculated?
Answer: By measuring an analyte in a portion of the general population,
calculating the mean, and determining the mean plus or minus 2
standard deviations.
⩥ What percentage of healthy individuals will typically fall outside the
reference range?
Answer: Approximately 5% (or 1 out of every 20 samples).
CHEMISTRY AND MOLECULAR
DIAGNOSTICS EIGHTH EDITION NADER
RIFAI CERTIFICATION EVALUATION
EXAMS COMPLETE QUESTIONS AND
VERIFIED SOLUTIONS GRADED A+
⩥ What is the primary role of redundancy in bodily systems during
disease?
Answer: The body uses redundant and complementary systems to
compensate for pathological changes.
⩥ List four categories of analytes measured in chemistry testing.
Answer: Analytes with biological function, nonfunctional
metabolites/waste products, indicators of cell damage/disease, and
drugs/toxic substances.
⩥ What is the most common specimen type used in clinical chemistry?
Answer: Blood (specifically serum, plasma, or whole blood).
⩥ Why is fasting often required for chemistry testing?
Answer: To ensure accurate results for analytes that fluctuate with
meals, such as glucose, triglycerides, and cholesterol.
, ⩥ What are diurnal variations in clinical chemistry?
Answer: Changes in analyte concentrations that occur at different times
of the day, such as with iron or corticosteroids.
⩥ What effect does hemolysis have on chemistry test results?
Answer: It causes increases in hemoglobin, enzymes, and potassium.
⩥ What is the result of failing to remove serum or plasma from cells in a
specimen?
Answer: A decrease in glucose concentration.
⩥ What does an 'icteric' specimen indicate?
Answer: The presence of excessive bilirubin.
⩥ How is a reference range typically calculated?
Answer: By measuring an analyte in a portion of the general population,
calculating the mean, and determining the mean plus or minus 2
standard deviations.
⩥ What percentage of healthy individuals will typically fall outside the
reference range?
Answer: Approximately 5% (or 1 out of every 20 samples).
