PRITE PSYCHOPHARMACOLOGY FINAL
PAPER FULL QUESTIONS AND CORRECT
ANSWERS REVIEW MATERIAL
●● Which antidepressant med is most likely to cause HTN? (5x)
Answer: VENLAFAXINE
●● Which antidepressant med is best to minimize risk of orthostasis in
an 84 y/o? (4x)
Answer: NORTRIPTYLINE
●● Antidepressant preferred for >65 y/o for which blood levels are
clinically useful (3x)
Answer: DESIPRAMINE
●● 62 y/o pt with hx chest pain has and depression, one month ago
started on paroxetine, presents with new onset of lethargy and headache,
low Na and BUN, normal K , and Cr of 0.4. Next test: (2x)
Answer: URINE OSMOLALITY
●● 38 y/o taking imipramine 300mg qday for recurrent MDD. After 3
weeks, mood is improved, but has difficulty passing urine and mild
erectile dysfunction. Appropriate action? (2x)
,Answer: BETHANECHOL 25MG TID
●● Antidepressant less likely to cause sexual dysfunction: (3x)
Answer: BUPROPION
●● Which is a muscarinic SE of antidepressants? (2x)
Answer: URINARY RETENTION
●● 30 y/o pt has been treated for unreasonable fear of eating in public
places, feeling of embarrassment in public places, and anger over the
possibility of being scrutinized. Pt has not responded to high doses of
paroxetine, citalopram, buspirone, and alprazolam, each of them
administered for 4-6 wks. Which meds would be appropriate for next?
(2x)
Answer: PHENELZINE
●● What meds could be helpful in the treatment of depression in persons
over the age of 65 because it does not produce orthostatic hypotension:
(2x)
Answer: BUPROPION
●● What antidepressant has plasma level that correlates with therapeutic
response? (3x)
Answer: IMIPRAMINE
,●● What antidepressant med is considered to be the most effective in the
tx of premature ejaculation? (x2)
Answer: PAROXETINE
●● Which opioid has a potentially lethal interaction with monoamine
oxidase inhibitors (MAOIs)? (4x)
Answer: MEPERIDINE
●● 45 y/o F pt on phenelzine for MDD, takes OTC medication for cold
sx and develops hypertensive crisis. Which OTC medication would most
likely cause this? (3x)
Answer: PSEUDOEPHEDRINE
●● Minimum recommended washout period for fluoxetine prior to
starting MAOI (2x)
Answer: 5 WEEKS
●● Treatment for patients with MAOI related hypertensive crisis in the
ER may involve the administration of which of the following meds? (2x)
Answer: PHENTOLAMINE
●● What drug has a curvilinear therapeutic window? (6x)
Answer: NORTRIPTYLINE
, ●● What drug is useful in the Rx of urinary retention secondary to TCA
therapy (5x)
Answer: BETHANECHOL
●● Most frequent cause of death following TCA overdose: (2x)
Answer: ARRHYTHMIA
●● After an OD on Amitriptyline, what test is needed? (4x)
Answer: EKG
●● Optimal strategy in maintenance tx with TCA for patient with
recurrent MDD (2x)
Answer: FULL DOSE ANTIDEPRESSANT THERAPY
●● Monitor TCA overdose using (2x)
Answer: EKG
●● Which SSRI has mild anticholinergic activity due to some affinity at
the muscarinic receptors? (3x)
Answer: PAROXETINE
●● Fluoxetine should NOT be prescribed with what? (2x)
PAPER FULL QUESTIONS AND CORRECT
ANSWERS REVIEW MATERIAL
●● Which antidepressant med is most likely to cause HTN? (5x)
Answer: VENLAFAXINE
●● Which antidepressant med is best to minimize risk of orthostasis in
an 84 y/o? (4x)
Answer: NORTRIPTYLINE
●● Antidepressant preferred for >65 y/o for which blood levels are
clinically useful (3x)
Answer: DESIPRAMINE
●● 62 y/o pt with hx chest pain has and depression, one month ago
started on paroxetine, presents with new onset of lethargy and headache,
low Na and BUN, normal K , and Cr of 0.4. Next test: (2x)
Answer: URINE OSMOLALITY
●● 38 y/o taking imipramine 300mg qday for recurrent MDD. After 3
weeks, mood is improved, but has difficulty passing urine and mild
erectile dysfunction. Appropriate action? (2x)
,Answer: BETHANECHOL 25MG TID
●● Antidepressant less likely to cause sexual dysfunction: (3x)
Answer: BUPROPION
●● Which is a muscarinic SE of antidepressants? (2x)
Answer: URINARY RETENTION
●● 30 y/o pt has been treated for unreasonable fear of eating in public
places, feeling of embarrassment in public places, and anger over the
possibility of being scrutinized. Pt has not responded to high doses of
paroxetine, citalopram, buspirone, and alprazolam, each of them
administered for 4-6 wks. Which meds would be appropriate for next?
(2x)
Answer: PHENELZINE
●● What meds could be helpful in the treatment of depression in persons
over the age of 65 because it does not produce orthostatic hypotension:
(2x)
Answer: BUPROPION
●● What antidepressant has plasma level that correlates with therapeutic
response? (3x)
Answer: IMIPRAMINE
,●● What antidepressant med is considered to be the most effective in the
tx of premature ejaculation? (x2)
Answer: PAROXETINE
●● Which opioid has a potentially lethal interaction with monoamine
oxidase inhibitors (MAOIs)? (4x)
Answer: MEPERIDINE
●● 45 y/o F pt on phenelzine for MDD, takes OTC medication for cold
sx and develops hypertensive crisis. Which OTC medication would most
likely cause this? (3x)
Answer: PSEUDOEPHEDRINE
●● Minimum recommended washout period for fluoxetine prior to
starting MAOI (2x)
Answer: 5 WEEKS
●● Treatment for patients with MAOI related hypertensive crisis in the
ER may involve the administration of which of the following meds? (2x)
Answer: PHENTOLAMINE
●● What drug has a curvilinear therapeutic window? (6x)
Answer: NORTRIPTYLINE
, ●● What drug is useful in the Rx of urinary retention secondary to TCA
therapy (5x)
Answer: BETHANECHOL
●● Most frequent cause of death following TCA overdose: (2x)
Answer: ARRHYTHMIA
●● After an OD on Amitriptyline, what test is needed? (4x)
Answer: EKG
●● Optimal strategy in maintenance tx with TCA for patient with
recurrent MDD (2x)
Answer: FULL DOSE ANTIDEPRESSANT THERAPY
●● Monitor TCA overdose using (2x)
Answer: EKG
●● Which SSRI has mild anticholinergic activity due to some affinity at
the muscarinic receptors? (3x)
Answer: PAROXETINE
●● Fluoxetine should NOT be prescribed with what? (2x)
