APEA Pre-Predictor & NP Board
Exam – High-Yield Practice Q&As
with Comprehensive Rationales
(Updated for AANP/ANCC
Blueprints)
, APEA 3P Exam Complete Study Guide
Questions, Multiple Choice, & Full
Rationales (NP Board Review)
1. What would cause a decrease in Digoxin
levels?
A. Beta-blockers
B. Antacids
C. Calcium-channel blockers
D. ACE inhibitors
CORRECT
ANSWER : B.
Antacids
Expert
Rationale:
Antacids bind with many medications in the GI tract and reduce
their absorption, including Digoxin.
This decreased absorption lowers serum Digoxin levels,
reducing therapeutic effect.
Patients should be instructed to separate Digoxin and antacids by
at least 2 hours. Failure to do so can result in subtherapeutic
Digoxin levels and worsening heart failure symptoms.
,Clinicians should monitor Digoxin levels if antacid use is frequent.
, 2. Taking Pyridium for a UTI—what can
Pyridium cause?
A. Thrombocytopenia
B. Hemolytic anemia
C. Renal stones
D. Bradycardia
CORRECT ANSWER
: B. Hemolytic anemia
Expert Rationale:
Phenazopyridine (Pyridium) is a urinary analgesic used for UTI
symptom relief. A rare but serious adverse effect is hemolytic
anemia, especially in patients with G6PD deficiency.
This occurs due to oxidative stress on red blood cells from
the medication. Symptoms may include jaundice, fatigue,
and dark urine.
The drug should not be used long-term and is intended only for
short symptomatic relief.
3. PCOS can result in which of the following?
A. Low insulin levels
B. Hyperinsulinemia and androgen excess
Exam – High-Yield Practice Q&As
with Comprehensive Rationales
(Updated for AANP/ANCC
Blueprints)
, APEA 3P Exam Complete Study Guide
Questions, Multiple Choice, & Full
Rationales (NP Board Review)
1. What would cause a decrease in Digoxin
levels?
A. Beta-blockers
B. Antacids
C. Calcium-channel blockers
D. ACE inhibitors
CORRECT
ANSWER : B.
Antacids
Expert
Rationale:
Antacids bind with many medications in the GI tract and reduce
their absorption, including Digoxin.
This decreased absorption lowers serum Digoxin levels,
reducing therapeutic effect.
Patients should be instructed to separate Digoxin and antacids by
at least 2 hours. Failure to do so can result in subtherapeutic
Digoxin levels and worsening heart failure symptoms.
,Clinicians should monitor Digoxin levels if antacid use is frequent.
, 2. Taking Pyridium for a UTI—what can
Pyridium cause?
A. Thrombocytopenia
B. Hemolytic anemia
C. Renal stones
D. Bradycardia
CORRECT ANSWER
: B. Hemolytic anemia
Expert Rationale:
Phenazopyridine (Pyridium) is a urinary analgesic used for UTI
symptom relief. A rare but serious adverse effect is hemolytic
anemia, especially in patients with G6PD deficiency.
This occurs due to oxidative stress on red blood cells from
the medication. Symptoms may include jaundice, fatigue,
and dark urine.
The drug should not be used long-term and is intended only for
short symptomatic relief.
3. PCOS can result in which of the following?
A. Low insulin levels
B. Hyperinsulinemia and androgen excess
