WGU D115 OA ADVANCED
PATHOPHYSIOLOGY 2026 COMPREHENSIVE
EXAM PREPARATION NOTES AND PRACTICE
QUESTIONS SET
◉ A patient presenting with Generalized Anxiety Disorder is most
likely to exhibit which primary symptoms?
A) Flashbacks and hypervigilance
B) Hallucinations and paranoia
C) Ritualistic hand washing
D) Impaired concentration and irritability.
Answer: D
◉ Which clinical findings are classic for a diagnosis of acute otitis
media?
A) Otalgia and muffled hearing
B) Dizziness and high-pitched tinnitus
C) Clear drainage and itching
D) Bone conduction greater than air conduction.
Answer: A
,◉ Which laboratory value is associated with increasing insulin
resistance?
A) LDL < 100 mg/dL
B) Fasting glucose of 90 mg/dL
C) Triglycerides > 150 mg/dL
D) HDL > 60 mg/dL.
Answer: C
◉ What is the underlying mechanism of Type 1 Diabetes Mellitus?
A) Chronic pancreatitis
B) Beta cell destruction leading to absolute deficiency
C) Excessive glucagon production
D) Peripheral insulin resistance.
Answer: B
◉ Which pharmacological intervention reduces the incidence of
endometrial cancer?
A) Estrogen-only therapy
B) Daily low-dose aspirin
C) Tamoxifen
D) Oral contraceptives.
Answer: D
,◉ Which imaging finding is a key feature in diagnosing ARDS?
A) Unilateral lobar consolidation
B) Bilateral infiltrates
C) Cephalization of pulmonary vessels
D) Enlarged cardiac silhouette.
Answer: B
◉ How is a formal diagnosis of hypertension determined?
A) BP measured on 2+ occasions averaged 2 mins apart
B) A single elevated reading in a clinical setting
C) One elevated reading at home and one in the clinic
D) A single reading of 130/80 mmHg.
Answer: A
◉ Which symptoms are most associated with left-sided heart
failure?
A) Peripheral edema and JVD
B) Ascites and hepatomegaly
C) Dyspnea and pulmonary congestion
D) Splenomegaly and anorexia.
Answer: C
, ◉ Pernicious anemia results from a lack of intrinsic factor.
Answer: necessary for absorbing:
A) Vitamin B12
B) Iron
C) Folic acid
D) Vitamin K, A
◉ Which compensatory mechanism is activated by kidneys in
response to decreased perfusion?
A) Release of ADH
B) Activation of the RAAS
C) Secretion of BNP
D) Inhibition of erythropoietin.
Answer: B
◉ What is the primary cause of Intrarenal Acute Kidney Injury
(AKI)?
A) Nephrolithiasis
B) Hypotension
C) Prostatic hypertrophy
D) Acute Tubular Necrosis (ATN).
PATHOPHYSIOLOGY 2026 COMPREHENSIVE
EXAM PREPARATION NOTES AND PRACTICE
QUESTIONS SET
◉ A patient presenting with Generalized Anxiety Disorder is most
likely to exhibit which primary symptoms?
A) Flashbacks and hypervigilance
B) Hallucinations and paranoia
C) Ritualistic hand washing
D) Impaired concentration and irritability.
Answer: D
◉ Which clinical findings are classic for a diagnosis of acute otitis
media?
A) Otalgia and muffled hearing
B) Dizziness and high-pitched tinnitus
C) Clear drainage and itching
D) Bone conduction greater than air conduction.
Answer: A
,◉ Which laboratory value is associated with increasing insulin
resistance?
A) LDL < 100 mg/dL
B) Fasting glucose of 90 mg/dL
C) Triglycerides > 150 mg/dL
D) HDL > 60 mg/dL.
Answer: C
◉ What is the underlying mechanism of Type 1 Diabetes Mellitus?
A) Chronic pancreatitis
B) Beta cell destruction leading to absolute deficiency
C) Excessive glucagon production
D) Peripheral insulin resistance.
Answer: B
◉ Which pharmacological intervention reduces the incidence of
endometrial cancer?
A) Estrogen-only therapy
B) Daily low-dose aspirin
C) Tamoxifen
D) Oral contraceptives.
Answer: D
,◉ Which imaging finding is a key feature in diagnosing ARDS?
A) Unilateral lobar consolidation
B) Bilateral infiltrates
C) Cephalization of pulmonary vessels
D) Enlarged cardiac silhouette.
Answer: B
◉ How is a formal diagnosis of hypertension determined?
A) BP measured on 2+ occasions averaged 2 mins apart
B) A single elevated reading in a clinical setting
C) One elevated reading at home and one in the clinic
D) A single reading of 130/80 mmHg.
Answer: A
◉ Which symptoms are most associated with left-sided heart
failure?
A) Peripheral edema and JVD
B) Ascites and hepatomegaly
C) Dyspnea and pulmonary congestion
D) Splenomegaly and anorexia.
Answer: C
, ◉ Pernicious anemia results from a lack of intrinsic factor.
Answer: necessary for absorbing:
A) Vitamin B12
B) Iron
C) Folic acid
D) Vitamin K, A
◉ Which compensatory mechanism is activated by kidneys in
response to decreased perfusion?
A) Release of ADH
B) Activation of the RAAS
C) Secretion of BNP
D) Inhibition of erythropoietin.
Answer: B
◉ What is the primary cause of Intrarenal Acute Kidney Injury
(AKI)?
A) Nephrolithiasis
B) Hypotension
C) Prostatic hypertrophy
D) Acute Tubular Necrosis (ATN).
