NURSE PRACTITIONER COMPREHENSIVE
QUESTIONS WITH 100% CORRECT
ANSWERS UPDATED 2026-2027
# Term Definition
1 Size of erythrocyte
Define: Mean Corpuscular Volume
(MCV)
2 Anterior pituitary gland
Where are growth hormones secreted
3
Define: Mean corpuscular
amount of hemo in each erythrocyte by weight
hemoglobine
4 Give s+s of acromegaly
excessive acral growth, facial features, sweating, HA,
peripheral neuropathy, decrase energy osteoarthitis,
depression, galactorrhea
5 concentration of hemo in each erythrocyte
Define: mean corpuscular hemoglobin
concentration
6
earliest most common: facial puffiness, broad nose,
Give physical exam of acromegaly
furrow brow, skin thickening
7 % of different types of hemo in erythrocytes
Define: Hemoglobin electrophoresis
8 What is the Diagnostic for acromegaly
Definitive test is the oral glucose tolerance test: GH
secretion should be suppressed by oral glucose load
9 ID depletion of iron in body
Obtain Serum ferritin determination
to:
, 10
Define transferring saturation and % transferring saturated w Fe acute hemorrhage,
disease which it might be abnormal: sideroblastic, anemia, IDA, thalassemia
11 Acromegaly and patient education
life long chronic progressive disease, physical changes
don't remit w/ therapy. But may slow down or stop
just cant reverse.
12 When may you find a abnormal
neutrophil count ie >than 0 myeloproliferative disorders, hematopoietic disorders,
hemolysis, infection, immune deficient
# Term Definition
13 What is Total Iron binding capacity
amount of Fe in serum plus amount of transferring
(TIBC) and when might you find it
available in serum IDA: TIBC: High due to low Fe we
abnormal?
have high capacity low Fe ACD: Low: less transferrin
(more ferritin)
14 destruction or reduction in adrenal gland
Addisons (adrenal gland disorder):
define
15
When do expect to see a rise in infection lymphocytosis, mononucleosis, anemias,
lymphocyte leukemia, hodgkins
16 S+S of Addison disease
N/V, hypotension, acute shock (trauma or
illness). Chronic: n/v, dizzy, chronic abd pain,
hyperpigment, lethargy weakness
17
When would you see an abnormal mononucleosis, monocytic leukemia, plasma cell
plasma cell count leukemia
18 chronically ill, dehydrated
PE how do patients with addison look
19 What diagnostic test are needed for
Addison disease Elevated ACTH and suppressed cortisol, hyponatremia,
hypercalemia (CMP), CXray (exclude TB)
, 20 plasma cell count
mononucleosis, monocytic leukemia, plasma cell
leukemia
21 Management of Addison disease
(chronic) oral hydrocortisone 20-30mg/d (restore diurnal
pattern) and fludrocortisone
(0.05-0.2mg/d) correct renal and hypotension.
22 Describe Erythropoietin patho
secreted by kidney response to tissue hypoxia-->
increase production of RBC
23 What is the management of acute
adrenal insufficiency IV hydrocortisone 100mg q 6hr for 24hr then taper.
hypotension, hypovolemia, hypoglycemia ICU
24 same as adults by 2 wks
Neutrophil should be the same as
adults at what age
# Term Definition
25 What is patient education of Addison
med adjust w/ fever and common illness
Disease
(hydrocortison doubled quickly) never stop steroids
quickly
26 high first year same as adult by 1 yr
when do eosinophil and monocytes
reach the level of adults in the body?
27 Define Cushings (basic) Over production of cortisol (adrenal disease)
28
What are characteristics of RBC:
macrocytic-normochromic anemaia (megoblastic)
deficient B12 or folate
29
What are S+S of chronic changes of weight loss, loss of menses, libido, depression
Cushings disease ,insomnia, bruising
, 30 pernicious anemai most commonly
due to B12 deficient: typcially chronic gastritis (DM1, thryroid,
graves, myasthenai gravis, alcohol, h. pylori)
31
What do you find on PE of Cushings exogenous/central obesity, moon face, thickening
disease facial fat, buffalo hump
32
Discuss folate Vit B for erythrocyte production, absorbedin upper
Macrocytic-normochromic intestin
33 24hr urine cortisol levels repeated 2-3x
What diagnostic do you perform for
Cushings
34 Sx of deficient folate
Macrocytic-normochromic scales, fissures in lips, corners of mouth , stomatitis,
sores ulceration of buccal and tounge swelling
35
Depends on source of hypercortisolism:
What is the management of Cushings
pituitary resection, Chemo,
36 iron deficient: diet, ASA, NSAID, GI surgery, pica
Most common anemia and cause craving
also microcytic -hypochromic
37 HTN >170systolic, arrythmias, tachy or brady
What do you find on PE of
pheochromocytoma:
# Term Definition
38
Sideroblastic anemia (SA) are rare:
Sx: iron overload erythropoietic hemochromatosis =
Symptoms include microcytic-
splenomegly and hepatomegaly
hypochromic
39 CAGE
Initial eval of alcoholic would include
what
QUESTIONS WITH 100% CORRECT
ANSWERS UPDATED 2026-2027
# Term Definition
1 Size of erythrocyte
Define: Mean Corpuscular Volume
(MCV)
2 Anterior pituitary gland
Where are growth hormones secreted
3
Define: Mean corpuscular
amount of hemo in each erythrocyte by weight
hemoglobine
4 Give s+s of acromegaly
excessive acral growth, facial features, sweating, HA,
peripheral neuropathy, decrase energy osteoarthitis,
depression, galactorrhea
5 concentration of hemo in each erythrocyte
Define: mean corpuscular hemoglobin
concentration
6
earliest most common: facial puffiness, broad nose,
Give physical exam of acromegaly
furrow brow, skin thickening
7 % of different types of hemo in erythrocytes
Define: Hemoglobin electrophoresis
8 What is the Diagnostic for acromegaly
Definitive test is the oral glucose tolerance test: GH
secretion should be suppressed by oral glucose load
9 ID depletion of iron in body
Obtain Serum ferritin determination
to:
, 10
Define transferring saturation and % transferring saturated w Fe acute hemorrhage,
disease which it might be abnormal: sideroblastic, anemia, IDA, thalassemia
11 Acromegaly and patient education
life long chronic progressive disease, physical changes
don't remit w/ therapy. But may slow down or stop
just cant reverse.
12 When may you find a abnormal
neutrophil count ie >than 0 myeloproliferative disorders, hematopoietic disorders,
hemolysis, infection, immune deficient
# Term Definition
13 What is Total Iron binding capacity
amount of Fe in serum plus amount of transferring
(TIBC) and when might you find it
available in serum IDA: TIBC: High due to low Fe we
abnormal?
have high capacity low Fe ACD: Low: less transferrin
(more ferritin)
14 destruction or reduction in adrenal gland
Addisons (adrenal gland disorder):
define
15
When do expect to see a rise in infection lymphocytosis, mononucleosis, anemias,
lymphocyte leukemia, hodgkins
16 S+S of Addison disease
N/V, hypotension, acute shock (trauma or
illness). Chronic: n/v, dizzy, chronic abd pain,
hyperpigment, lethargy weakness
17
When would you see an abnormal mononucleosis, monocytic leukemia, plasma cell
plasma cell count leukemia
18 chronically ill, dehydrated
PE how do patients with addison look
19 What diagnostic test are needed for
Addison disease Elevated ACTH and suppressed cortisol, hyponatremia,
hypercalemia (CMP), CXray (exclude TB)
, 20 plasma cell count
mononucleosis, monocytic leukemia, plasma cell
leukemia
21 Management of Addison disease
(chronic) oral hydrocortisone 20-30mg/d (restore diurnal
pattern) and fludrocortisone
(0.05-0.2mg/d) correct renal and hypotension.
22 Describe Erythropoietin patho
secreted by kidney response to tissue hypoxia-->
increase production of RBC
23 What is the management of acute
adrenal insufficiency IV hydrocortisone 100mg q 6hr for 24hr then taper.
hypotension, hypovolemia, hypoglycemia ICU
24 same as adults by 2 wks
Neutrophil should be the same as
adults at what age
# Term Definition
25 What is patient education of Addison
med adjust w/ fever and common illness
Disease
(hydrocortison doubled quickly) never stop steroids
quickly
26 high first year same as adult by 1 yr
when do eosinophil and monocytes
reach the level of adults in the body?
27 Define Cushings (basic) Over production of cortisol (adrenal disease)
28
What are characteristics of RBC:
macrocytic-normochromic anemaia (megoblastic)
deficient B12 or folate
29
What are S+S of chronic changes of weight loss, loss of menses, libido, depression
Cushings disease ,insomnia, bruising
, 30 pernicious anemai most commonly
due to B12 deficient: typcially chronic gastritis (DM1, thryroid,
graves, myasthenai gravis, alcohol, h. pylori)
31
What do you find on PE of Cushings exogenous/central obesity, moon face, thickening
disease facial fat, buffalo hump
32
Discuss folate Vit B for erythrocyte production, absorbedin upper
Macrocytic-normochromic intestin
33 24hr urine cortisol levels repeated 2-3x
What diagnostic do you perform for
Cushings
34 Sx of deficient folate
Macrocytic-normochromic scales, fissures in lips, corners of mouth , stomatitis,
sores ulceration of buccal and tounge swelling
35
Depends on source of hypercortisolism:
What is the management of Cushings
pituitary resection, Chemo,
36 iron deficient: diet, ASA, NSAID, GI surgery, pica
Most common anemia and cause craving
also microcytic -hypochromic
37 HTN >170systolic, arrythmias, tachy or brady
What do you find on PE of
pheochromocytoma:
# Term Definition
38
Sideroblastic anemia (SA) are rare:
Sx: iron overload erythropoietic hemochromatosis =
Symptoms include microcytic-
splenomegly and hepatomegaly
hypochromic
39 CAGE
Initial eval of alcoholic would include
what
