Pharmacy Practice Exam
1. Which organ is primarily responsible for drug metabolism?
A. Kidney
B. Lung
C. Liver
D. Pancreas
Rationale: The liver contains enzymes, particularly the cytochrome P450 system,
responsible for metabolizing many medications.
2. Which route of administration bypasses first-pass metabolism?
A. Oral
B. Rectal
C. Intravenous
D. Gastric tube
Rationale: Intravenous administration delivers medication directly into the
bloodstream, avoiding first-pass hepatic metabolism.
3. What is the antidote for opioid overdose?
A. Flumazenil
B. Atropine
C. Protamine sulfate
D. Naloxone
Rationale: Naloxone rapidly reverses opioid-induced respiratory depression by
competitively blocking opioid receptors.
4. Which drug class is commonly used to treat hypertension?
,A. Antifungals
B. Antivirals
C. ACE inhibitors
D. Antacids
Rationale: ACE inhibitors lower blood pressure by blocking conversion of
angiotensin I to angiotensin II.
5. Which electrolyte abnormality is commonly associated with loop diuretics?
A. Hypercalcemia
B. Hypernatremia
C. Hypokalemia
D. Hypermagnesemia
Rationale: Loop diuretics increase potassium excretion, often causing
hypokalemia.
6. What does PRN mean on a prescription?
A. Before meals
B. At bedtime
C. Twice daily
D. As needed
Rationale: PRN comes from the Latin phrase "pro re nata," meaning as
circumstances require.
7. Which insulin has the fastest onset of action?
A. NPH
B. Glargine
C. Detemir
D. Lispro
Rationale: Lispro is a rapid-acting insulin with onset typically within 15 minutes.
8. Which medication is used to treat hypothyroidism?
, A. Methimazole
B. Propylthiouracil
C. Levothyroxine
D. Iodine solution
Rationale: Levothyroxine is synthetic T4 used as replacement therapy.
9. Which antibiotic is associated with tendon rupture?
A. Amoxicillin
B. Azithromycin
C. Ciprofloxacin
D. Vancomycin
Rationale: Fluoroquinolones have a known risk of tendonitis and tendon
rupture.
10.What is the therapeutic INR range for most patients on warfarin?
A. 0.5–1.0
B. 1.0–1.5
C. 2.0–3.0
D. 4.0–5.0
Rationale: Most anticoagulation indications target an INR of 2.0–3.0.
11.Which vitamin is routinely administered with isoniazid?
A. Vitamin C
B. Vitamin D
C. Vitamin B6 (Pyridoxine)
D. Vitamin K
Rationale: Pyridoxine helps prevent peripheral neuropathy associated with
isoniazid.
12.Which medication is a beta blocker?
1. Which organ is primarily responsible for drug metabolism?
A. Kidney
B. Lung
C. Liver
D. Pancreas
Rationale: The liver contains enzymes, particularly the cytochrome P450 system,
responsible for metabolizing many medications.
2. Which route of administration bypasses first-pass metabolism?
A. Oral
B. Rectal
C. Intravenous
D. Gastric tube
Rationale: Intravenous administration delivers medication directly into the
bloodstream, avoiding first-pass hepatic metabolism.
3. What is the antidote for opioid overdose?
A. Flumazenil
B. Atropine
C. Protamine sulfate
D. Naloxone
Rationale: Naloxone rapidly reverses opioid-induced respiratory depression by
competitively blocking opioid receptors.
4. Which drug class is commonly used to treat hypertension?
,A. Antifungals
B. Antivirals
C. ACE inhibitors
D. Antacids
Rationale: ACE inhibitors lower blood pressure by blocking conversion of
angiotensin I to angiotensin II.
5. Which electrolyte abnormality is commonly associated with loop diuretics?
A. Hypercalcemia
B. Hypernatremia
C. Hypokalemia
D. Hypermagnesemia
Rationale: Loop diuretics increase potassium excretion, often causing
hypokalemia.
6. What does PRN mean on a prescription?
A. Before meals
B. At bedtime
C. Twice daily
D. As needed
Rationale: PRN comes from the Latin phrase "pro re nata," meaning as
circumstances require.
7. Which insulin has the fastest onset of action?
A. NPH
B. Glargine
C. Detemir
D. Lispro
Rationale: Lispro is a rapid-acting insulin with onset typically within 15 minutes.
8. Which medication is used to treat hypothyroidism?
, A. Methimazole
B. Propylthiouracil
C. Levothyroxine
D. Iodine solution
Rationale: Levothyroxine is synthetic T4 used as replacement therapy.
9. Which antibiotic is associated with tendon rupture?
A. Amoxicillin
B. Azithromycin
C. Ciprofloxacin
D. Vancomycin
Rationale: Fluoroquinolones have a known risk of tendonitis and tendon
rupture.
10.What is the therapeutic INR range for most patients on warfarin?
A. 0.5–1.0
B. 1.0–1.5
C. 2.0–3.0
D. 4.0–5.0
Rationale: Most anticoagulation indications target an INR of 2.0–3.0.
11.Which vitamin is routinely administered with isoniazid?
A. Vitamin C
B. Vitamin D
C. Vitamin B6 (Pyridoxine)
D. Vitamin K
Rationale: Pyridoxine helps prevent peripheral neuropathy associated with
isoniazid.
12.Which medication is a beta blocker?
