ATI PHARMACOLOGY GASTROINTESTINAL
SYSTEM TEST BANK MIDTERM EXAM 4 WITH
COMPLETE QUESTIONS AND ANSWERS
(VERIFIED ANSWERS) LATEST UPDATE FOR
MIDTERM PREP 2026-2027
which drugs are PPIs?
-Omeprazole
-Esomeprazole
-Lansoprazole
-Dexlansoprazole
-Pantoprazole
-Rabeprazole
which PPIs are available OTC?
-omeprazole
-esomeprazole
-lansoprazole
,how long can you take PPI OTC?
no longer than 14 days, do not repeat more often than every 4 months
PPI MOA
-irreversibly inactivates H/K/ATPase pump of parietal cells
-prodrugs that rapidly convert to active cation forms covalent disulfide
linkage to pump, resulting in inactivation and blocking transport of acid
from cell into lumen
-long acting way to suppress production/secretion of stomach acid
are PPIs for immediate relief?
no, begin working within 1-3 hours but take 1-4 days for full effect
when should you take a PPI?
30 min before eating
is a PPI, H2 blocker or antacid the most effective?
PPI
,PPI S/E
-systemic lupus
-possible C. diff infection
-osteoporosis
-vitamin B12 deficiency
Omeprazole and Esomeprazole have issues with ____
Clopidogrel
what is Zegrid?
-PPI combo of Omeprazole and sodium bicarbonate (PPI + antacid)
what is peptic ulcer disease
-group of disorders of upper GI tract characterized by ulcerative lesions
that depend on acid and pepsin for formation
-form from long-term uncontrolled GERD
-duodenal ulcers more common than gastric
what happens to the lining of stomach/esophagus with PUD?
-acid eats away at stomach or esophageal lining
, 3 common forms of duodenal/gastric ulcers are related to what?
-H. pylori: duodenal
-NSAIDs: gastric
-severe physiologic stress: both
what is H. pylori?
-gram negative bacteria that inhabits area between stomach's mucosal
layer and epithelial cells
-causes duodenal inflammation, increases duodenal acid load, and
impairs duodenal bicarbonate secretion
what is the triple therapy for treating H. pylori PUD?
-PPI/Clarithromycin/Amoxicillin
SYSTEM TEST BANK MIDTERM EXAM 4 WITH
COMPLETE QUESTIONS AND ANSWERS
(VERIFIED ANSWERS) LATEST UPDATE FOR
MIDTERM PREP 2026-2027
which drugs are PPIs?
-Omeprazole
-Esomeprazole
-Lansoprazole
-Dexlansoprazole
-Pantoprazole
-Rabeprazole
which PPIs are available OTC?
-omeprazole
-esomeprazole
-lansoprazole
,how long can you take PPI OTC?
no longer than 14 days, do not repeat more often than every 4 months
PPI MOA
-irreversibly inactivates H/K/ATPase pump of parietal cells
-prodrugs that rapidly convert to active cation forms covalent disulfide
linkage to pump, resulting in inactivation and blocking transport of acid
from cell into lumen
-long acting way to suppress production/secretion of stomach acid
are PPIs for immediate relief?
no, begin working within 1-3 hours but take 1-4 days for full effect
when should you take a PPI?
30 min before eating
is a PPI, H2 blocker or antacid the most effective?
PPI
,PPI S/E
-systemic lupus
-possible C. diff infection
-osteoporosis
-vitamin B12 deficiency
Omeprazole and Esomeprazole have issues with ____
Clopidogrel
what is Zegrid?
-PPI combo of Omeprazole and sodium bicarbonate (PPI + antacid)
what is peptic ulcer disease
-group of disorders of upper GI tract characterized by ulcerative lesions
that depend on acid and pepsin for formation
-form from long-term uncontrolled GERD
-duodenal ulcers more common than gastric
what happens to the lining of stomach/esophagus with PUD?
-acid eats away at stomach or esophageal lining
, 3 common forms of duodenal/gastric ulcers are related to what?
-H. pylori: duodenal
-NSAIDs: gastric
-severe physiologic stress: both
what is H. pylori?
-gram negative bacteria that inhabits area between stomach's mucosal
layer and epithelial cells
-causes duodenal inflammation, increases duodenal acid load, and
impairs duodenal bicarbonate secretion
what is the triple therapy for treating H. pylori PUD?
-PPI/Clarithromycin/Amoxicillin
