HESI LPN Entrance Exam 2026: 100 Realistic
Practice Questions with Verified Answers &
Detailed Rationales
1.
A patient is prescribed 750 mg of medication. Tablets are 250 mg each. How many tablets
are needed?
Answer: 3 tablets
Rationale: 750 ÷ 250 = 3
2.
Convert 0.5 liters to milliliters.
A. 5 mL
B. 50 mL
C. 500 mL
D. 5000 mL
Answer: C. 500 mL
Rationale: 1 L = 1000 mL, so 0.5 × 1000 = 500 mL
3.
A nurse must administer 1.5 g of medication. The vial contains 500 mg tablets. How many
tablets are required?
Answer: 3 tablets
Rationale: 1.5 g = 1500 mg → 1500 ÷ 500 = 3
4.
What is 25% of 80?
Answer: 20
Rationale: 0.25 × 80 = 20
5.
,A patient drinks 240 mL of water every 4 hours. How much in 24 hours?
Answer: 1440 mL
Rationale: 24 ÷ 4 = 6 doses → 6 × 240 = 1440 mL
6.
Solve: ¾ + 1/8
Answer: 7/8
Rationale: ¾ = 6/8 → 6/8 + 1/8 = 7/8
7.
A doctor orders 1000 mg. Available: 0.5 g tablets. How many tablets?
Answer: 2 tablets
Rationale: 0.5 g = 500 mg → 1000 ÷ 500 = 2
8.
What is the ratio of 10:50 simplified?
Answer: 1:5
Rationale: Divide both by 10
READING COMPREHENSION (9–14)
9.
Passage: “Hand hygiene reduces the spread of infection in healthcare settings.”
What is the main idea?
Answer: Hand hygiene prevents infection spread
Rationale: It directly restates the passage meaning.
10.
What is the purpose of a paragraph’s topic sentence?
Answer: To introduce the main idea
Rationale: It summarizes the paragraph’s focus.
11.
, Which word means “to improve”?
A. Worsen
B. Enhance
C. Remove
D. Delay
Answer: B. Enhance
12.
Inference: A patient refuses medication due to fear of side effects. What is most likely true?
Answer: The patient is anxious about treatment
Rationale: Refusal due to fear indicates anxiety.
13.
Which sentence shows cause and effect?
Answer: “Because the patient exercised, blood pressure improved.”
Rationale: “Because” shows cause-effect relationship.
14.
What is the author’s purpose in a medical instruction manual?
Answer: To inform and instruct
Rationale: Manuals provide guidance.
VOCABULARY (15–18)
15.
“Acute” means:
A. Chronic
B. Sudden
C. Mild
D. Permanent
Answer: B. Sudden
Practice Questions with Verified Answers &
Detailed Rationales
1.
A patient is prescribed 750 mg of medication. Tablets are 250 mg each. How many tablets
are needed?
Answer: 3 tablets
Rationale: 750 ÷ 250 = 3
2.
Convert 0.5 liters to milliliters.
A. 5 mL
B. 50 mL
C. 500 mL
D. 5000 mL
Answer: C. 500 mL
Rationale: 1 L = 1000 mL, so 0.5 × 1000 = 500 mL
3.
A nurse must administer 1.5 g of medication. The vial contains 500 mg tablets. How many
tablets are required?
Answer: 3 tablets
Rationale: 1.5 g = 1500 mg → 1500 ÷ 500 = 3
4.
What is 25% of 80?
Answer: 20
Rationale: 0.25 × 80 = 20
5.
,A patient drinks 240 mL of water every 4 hours. How much in 24 hours?
Answer: 1440 mL
Rationale: 24 ÷ 4 = 6 doses → 6 × 240 = 1440 mL
6.
Solve: ¾ + 1/8
Answer: 7/8
Rationale: ¾ = 6/8 → 6/8 + 1/8 = 7/8
7.
A doctor orders 1000 mg. Available: 0.5 g tablets. How many tablets?
Answer: 2 tablets
Rationale: 0.5 g = 500 mg → 1000 ÷ 500 = 2
8.
What is the ratio of 10:50 simplified?
Answer: 1:5
Rationale: Divide both by 10
READING COMPREHENSION (9–14)
9.
Passage: “Hand hygiene reduces the spread of infection in healthcare settings.”
What is the main idea?
Answer: Hand hygiene prevents infection spread
Rationale: It directly restates the passage meaning.
10.
What is the purpose of a paragraph’s topic sentence?
Answer: To introduce the main idea
Rationale: It summarizes the paragraph’s focus.
11.
, Which word means “to improve”?
A. Worsen
B. Enhance
C. Remove
D. Delay
Answer: B. Enhance
12.
Inference: A patient refuses medication due to fear of side effects. What is most likely true?
Answer: The patient is anxious about treatment
Rationale: Refusal due to fear indicates anxiety.
13.
Which sentence shows cause and effect?
Answer: “Because the patient exercised, blood pressure improved.”
Rationale: “Because” shows cause-effect relationship.
14.
What is the author’s purpose in a medical instruction manual?
Answer: To inform and instruct
Rationale: Manuals provide guidance.
VOCABULARY (15–18)
15.
“Acute” means:
A. Chronic
B. Sudden
C. Mild
D. Permanent
Answer: B. Sudden
