PHM 431 Exam 3 ACTUAL QUESTIONS
AND CORRECT ANSWERS
Caffeine in moderate doses has been shown to improve cognitive performance. The action of caffeine
is mediated predominantly by___________ - CORRECT ANSWER A1 adenosine receptors in
the cerebral cortex
Both mice treated with caffeine. KO gene causes decreased locomotor activity. What is the gene? -
CORRECT ANSWER A2A receptor in the striatum (striatum = controls locomotor movements)
Caffeine protects against the risk of developing what? - CORRECT ANSWER Parkinsons
Combining alcohol with energy drinks causes _____________ - CORRECT
ANSWER reduction in perceived intoxication, increased drinking behaviors, increased alcohol
consumption
Disulfuram is being tested as a treatment for cocaine addiction because it blocks _________________
- CORRECT ANSWER Dopamine beta-hydroxylase (DBH)
Blood samples taken from an overdose victim indicate cocaethylene, benzoylecognidine, and
ecgonidine methylester. What was the overdose caused by? - CORRECT ANSWER alcohol and
cocaine HCl
A unique feature of cocaine use is sensitization (rather than tolerance) to cocaine's effects. KO of
which gene would reduce behavioral sensitization to the effects of repeated cocaine administration? -
CORRECT ANSWER delta fos B
Detection of benzoylecognidine in a urine sample would indicate the use of what drug? - CORRECT
ANSWER cocaine
Which drugs are a substrate for the vesicular monoamine transporter (VMAT) - CORRECT
ANSWER methamphetamine and amphetamine
AND CORRECT ANSWERS
Caffeine in moderate doses has been shown to improve cognitive performance. The action of caffeine
is mediated predominantly by___________ - CORRECT ANSWER A1 adenosine receptors in
the cerebral cortex
Both mice treated with caffeine. KO gene causes decreased locomotor activity. What is the gene? -
CORRECT ANSWER A2A receptor in the striatum (striatum = controls locomotor movements)
Caffeine protects against the risk of developing what? - CORRECT ANSWER Parkinsons
Combining alcohol with energy drinks causes _____________ - CORRECT
ANSWER reduction in perceived intoxication, increased drinking behaviors, increased alcohol
consumption
Disulfuram is being tested as a treatment for cocaine addiction because it blocks _________________
- CORRECT ANSWER Dopamine beta-hydroxylase (DBH)
Blood samples taken from an overdose victim indicate cocaethylene, benzoylecognidine, and
ecgonidine methylester. What was the overdose caused by? - CORRECT ANSWER alcohol and
cocaine HCl
A unique feature of cocaine use is sensitization (rather than tolerance) to cocaine's effects. KO of
which gene would reduce behavioral sensitization to the effects of repeated cocaine administration? -
CORRECT ANSWER delta fos B
Detection of benzoylecognidine in a urine sample would indicate the use of what drug? - CORRECT
ANSWER cocaine
Which drugs are a substrate for the vesicular monoamine transporter (VMAT) - CORRECT
ANSWER methamphetamine and amphetamine
