COMSAE Phase 1 Form 115 Exam
Practice Questions And Correct Answers
(Verified Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A 24-year-old man develops fever, headache, and neck stiffness.
Cerebrospinal fluid analysis shows elevated neutrophils, decreased
glucose, and increased protein. Which organism is the most likely
cause?
A. Cryptococcus neoformans
B. Mycobacterium tuberculosis
C. Neisseria meningitidis
D. JC virus
The presence of acute bacterial meningitis with neutrophilic
predominance, low glucose, and elevated protein is most consistent with
Neisseria meningitidis in a young adult.
, 2. A patient presents with severe chest pain radiating to the left arm.
Which laboratory marker rises earliest after myocardial infarction?
A. Troponin I
B. Troponin T
C. CK-MB
D. Myoglobin
Myoglobin rises within 1–2 hours after myocardial injury, making it the
earliest detectable marker, although it is less specific than troponins.
3. A researcher studies a receptor that activates adenylate cyclase
through Gs proteins. Which second messenger increases?
A. IP3
B. DAG
C. Calcium
D. cAMP
Gs protein stimulation activates adenylate cyclase, increasing intracellular
cyclic AMP concentrations.
4. A child develops recurrent respiratory infections and situs inversus.
Which structural defect is most likely present?
A. Microtubule depolymerization
B. Intermediate filament defect
,C. Dynein arm defect
D. Actin polymerization defect
Kartagener syndrome results from dynein arm dysfunction, causing
immotile cilia, recurrent infections, and situs inversus.
5. Which vitamin deficiency is most strongly associated with
megaloblastic anemia and neurologic deficits?
A. Vitamin C
B. Folate
C. Vitamin B12
D. Vitamin K
Vitamin B12 deficiency causes megaloblastic anemia and demyelination
leading to neurologic symptoms.
6. A patient with hyperthyroidism is treated with propylthiouracil. What
additional action does this drug have besides inhibiting thyroid
peroxidase?
A. Stimulates TSH release
B. Blocks iodine uptake
C. Inhibits peripheral conversion of T4 to T3
D. Increases thyroglobulin synthesis
, Propylthiouracil uniquely inhibits 5'-deiodinase, reducing peripheral
conversion of T4 to active T3.
7. Which cranial nerve is responsible for sensation from the anterior two-
thirds of the tongue?
A. Glossopharyngeal nerve
B. Vagus nerve
C. Facial nerve
D. Trigeminal nerve (V3)
General sensory innervation of the anterior two-thirds of the tongue is
provided by the lingual nerve, a branch of CN V3.
8. A patient develops nephrotic syndrome with diffuse foot process
effacement on electron microscopy. What is the diagnosis?
A. Membranous nephropathy
B. Focal segmental glomerulosclerosis
C. Minimal change disease
D. Rapidly progressive glomerulonephritis
Minimal change disease demonstrates diffuse podocyte foot process
effacement and commonly causes nephrotic syndrome.
9. Which enzyme converts angiotensin I to angiotensin II?
Practice Questions And Correct Answers
(Verified Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A 24-year-old man develops fever, headache, and neck stiffness.
Cerebrospinal fluid analysis shows elevated neutrophils, decreased
glucose, and increased protein. Which organism is the most likely
cause?
A. Cryptococcus neoformans
B. Mycobacterium tuberculosis
C. Neisseria meningitidis
D. JC virus
The presence of acute bacterial meningitis with neutrophilic
predominance, low glucose, and elevated protein is most consistent with
Neisseria meningitidis in a young adult.
, 2. A patient presents with severe chest pain radiating to the left arm.
Which laboratory marker rises earliest after myocardial infarction?
A. Troponin I
B. Troponin T
C. CK-MB
D. Myoglobin
Myoglobin rises within 1–2 hours after myocardial injury, making it the
earliest detectable marker, although it is less specific than troponins.
3. A researcher studies a receptor that activates adenylate cyclase
through Gs proteins. Which second messenger increases?
A. IP3
B. DAG
C. Calcium
D. cAMP
Gs protein stimulation activates adenylate cyclase, increasing intracellular
cyclic AMP concentrations.
4. A child develops recurrent respiratory infections and situs inversus.
Which structural defect is most likely present?
A. Microtubule depolymerization
B. Intermediate filament defect
,C. Dynein arm defect
D. Actin polymerization defect
Kartagener syndrome results from dynein arm dysfunction, causing
immotile cilia, recurrent infections, and situs inversus.
5. Which vitamin deficiency is most strongly associated with
megaloblastic anemia and neurologic deficits?
A. Vitamin C
B. Folate
C. Vitamin B12
D. Vitamin K
Vitamin B12 deficiency causes megaloblastic anemia and demyelination
leading to neurologic symptoms.
6. A patient with hyperthyroidism is treated with propylthiouracil. What
additional action does this drug have besides inhibiting thyroid
peroxidase?
A. Stimulates TSH release
B. Blocks iodine uptake
C. Inhibits peripheral conversion of T4 to T3
D. Increases thyroglobulin synthesis
, Propylthiouracil uniquely inhibits 5'-deiodinase, reducing peripheral
conversion of T4 to active T3.
7. Which cranial nerve is responsible for sensation from the anterior two-
thirds of the tongue?
A. Glossopharyngeal nerve
B. Vagus nerve
C. Facial nerve
D. Trigeminal nerve (V3)
General sensory innervation of the anterior two-thirds of the tongue is
provided by the lingual nerve, a branch of CN V3.
8. A patient develops nephrotic syndrome with diffuse foot process
effacement on electron microscopy. What is the diagnosis?
A. Membranous nephropathy
B. Focal segmental glomerulosclerosis
C. Minimal change disease
D. Rapidly progressive glomerulonephritis
Minimal change disease demonstrates diffuse podocyte foot process
effacement and commonly causes nephrotic syndrome.
9. Which enzyme converts angiotensin I to angiotensin II?
