Natalizumab (Tysabri)
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Blocks Anti alpha-4 integrin molecules systemically. Prevents
WBC/Leukocyte to adhere and migrate to area of infection and prevent
myelin damage. As a result, it can also block WBC to migrate into brain to
prevent viral infections from occurring leading to PML- viral brain infection.
Joint replacement NI
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Check neurovascular (pulses, cap refill, color, sensation, warmth, edema,
motor ability, incision, increased pain)
Get out of bed w/in 4 to 6 hours (must have nurse or PT there first time)
Watch for DVTs
Encourage to cough/use IS
, Should not be flexed more than 90 degrees until full weight baring (use
toilet booster, OT, no adduction of leg, no internal leg rotation)
Ask about significant pain-compartment syndrome
Diagnostics
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X-ray
CT (vertebral column and joint issues)
MRI (more accurate than CT for joints)
Arthrography (study of joint after contrast)
Bone mineral density (1 to -1 healthy; -1 to -2.5 osteopenia; less than -2.5
osteoporosis)
Bone scan
Arthroscopy (tube inserted into joint to visualize ligaments, menisci, and
articular surfaces; normally knee or shoulder)
Electromyography
Primary prevention
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physical activity
ideal body weight
adequate rest
nutriton
fall prevention
positioning to prevent breakdown (pressure injuries)
cast care
, Joint replacement treatments
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PT
CPM (continuous passive motion for knee, very old term; cannot delegate
changing setting; should turn off while eating; monitor Gi, GU, respiratory)
Medication (TXA-antifibirinolytic to stop bleeding. Given during surgery)
MS populations
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between 20 and 50
normally northern european ancestry
2 times more likely in women
risks for osteoporosis
Give this one a try later!
Give this one a try later!
Blocks Anti alpha-4 integrin molecules systemically. Prevents
WBC/Leukocyte to adhere and migrate to area of infection and prevent
myelin damage. As a result, it can also block WBC to migrate into brain to
prevent viral infections from occurring leading to PML- viral brain infection.
Joint replacement NI
Give this one a try later!
Check neurovascular (pulses, cap refill, color, sensation, warmth, edema,
motor ability, incision, increased pain)
Get out of bed w/in 4 to 6 hours (must have nurse or PT there first time)
Watch for DVTs
Encourage to cough/use IS
, Should not be flexed more than 90 degrees until full weight baring (use
toilet booster, OT, no adduction of leg, no internal leg rotation)
Ask about significant pain-compartment syndrome
Diagnostics
Give this one a try later!
X-ray
CT (vertebral column and joint issues)
MRI (more accurate than CT for joints)
Arthrography (study of joint after contrast)
Bone mineral density (1 to -1 healthy; -1 to -2.5 osteopenia; less than -2.5
osteoporosis)
Bone scan
Arthroscopy (tube inserted into joint to visualize ligaments, menisci, and
articular surfaces; normally knee or shoulder)
Electromyography
Primary prevention
Give this one a try later!
physical activity
ideal body weight
adequate rest
nutriton
fall prevention
positioning to prevent breakdown (pressure injuries)
cast care
, Joint replacement treatments
Give this one a try later!
PT
CPM (continuous passive motion for knee, very old term; cannot delegate
changing setting; should turn off while eating; monitor Gi, GU, respiratory)
Medication (TXA-antifibirinolytic to stop bleeding. Given during surgery)
MS populations
Give this one a try later!
between 20 and 50
normally northern european ancestry
2 times more likely in women
risks for osteoporosis
Give this one a try later!
