COMSAE 114 EXAM | REAL QUESTIONS
WITH CORRECT ANSWERS AND EXPERT
VERIFIED RATIONALES | GUARANTEED
EXAM EXCELLENCE
1. What is the first-line pharmacologic treatment for
essential hypertension without comorbidities?
A) ACE inhibitors
B) Beta-blockers
C) Thiazide diuretics
D) Calcium channel blockers
Correct Answer: C
Rationale: Thiazide diuretics are recommended as
first-line therapy for essential hypertension in
patients without comorbidities based on clinical trial
evidence for cardiovascular event reduction.
2. What is the underlying pathophysiology of
Goodpasture syndrome?
A) Immune complex deposition in glomeruli only
B) Damage to alveolar and renal glomerular
basement membranes by cytotoxic antibody
,C) IgA deposition in renal mesangium
D) Complement deficiency leading to recurrent
infections
Correct Answer: B
Rationale: Goodpasture syndrome is caused by
cytotoxic antibodies targeting alveolar and renal
glomerular basement membranes, leading to
pulmonary hemorrhage and rapidly progressive
glomerulonephritis.
3. What are the signs and symptoms of Goodpasture
syndrome? (Select all that apply)
A) Hemoptysis
B) Dyspnea
C) Rapidly progressive kidney failure
D) Proteinuria and lower extremity edema
Correct Answer: A, B, C, D
Rationale: Goodpasture syndrome presents with
pulmonary manifestations (hemoptysis, dyspnea) and
renal manifestations (rapidly progressive kidney
failure, proteinuria, edema).
4. What does the mnemonic SOAP BRAIN MD
represent?
,A) Treatment algorithm for rheumatoid arthritis
B) Diagnostic criteria for systemic lupus
erythematosus
C) Contraindications for hormone therapy
D) Risk factors for osteoporosis
Correct Answer: B
Rationale: SOAP BRAIN MD is a mnemonic for the
diagnostic criteria of systemic lupus erythematosus:
Serositis, Oral/nasal ulcers, Arthritis,
Photosensitivity, Blood disorders, Renal dysfunction,
ANA+, Immunoglobulins (anti-dsDNA), Neuro
symptoms, Malar rash, Discoid rash.
5. What is porphyria?
A) A bacterial skin infection caused by
Staphylococcus
B) A sunlight sensitivity disorder causing allergy to
UV rays
C) An autoimmune blistering disease
D) A fungal infection of the nails
Correct Answer: B
Rationale: Porphyria is a disorder of heme
biosynthesis that causes photosensitivity, making
, affected individuals allergic or sensitive to ultraviolet
rays.
6. What is the characteristic imaging finding in
pulmonary anthrax?
A) Bilateral hilar lymphadenopathy
B) Widened mediastinum
C) Cavitary lung lesions
D) Pleural effusion with air trapping
Correct Answer: B
Rationale: Pulmonary anthrax classically presents
with a widened mediastinum on chest imaging due to
hemorrhagic mediastinitis.
7. What is aortocaval compression?
A) Compression of the aorta and vena cava by a
thoracic aneurysm
B) Compression of the aorta and vena cava by the
gravid uterus in the supine pregnant patient
C) Congenital narrowing of the aorta and vena cava
D) Compression of the aorta and vena cava by a
retroperitoneal tumor
Correct Answer: B
WITH CORRECT ANSWERS AND EXPERT
VERIFIED RATIONALES | GUARANTEED
EXAM EXCELLENCE
1. What is the first-line pharmacologic treatment for
essential hypertension without comorbidities?
A) ACE inhibitors
B) Beta-blockers
C) Thiazide diuretics
D) Calcium channel blockers
Correct Answer: C
Rationale: Thiazide diuretics are recommended as
first-line therapy for essential hypertension in
patients without comorbidities based on clinical trial
evidence for cardiovascular event reduction.
2. What is the underlying pathophysiology of
Goodpasture syndrome?
A) Immune complex deposition in glomeruli only
B) Damage to alveolar and renal glomerular
basement membranes by cytotoxic antibody
,C) IgA deposition in renal mesangium
D) Complement deficiency leading to recurrent
infections
Correct Answer: B
Rationale: Goodpasture syndrome is caused by
cytotoxic antibodies targeting alveolar and renal
glomerular basement membranes, leading to
pulmonary hemorrhage and rapidly progressive
glomerulonephritis.
3. What are the signs and symptoms of Goodpasture
syndrome? (Select all that apply)
A) Hemoptysis
B) Dyspnea
C) Rapidly progressive kidney failure
D) Proteinuria and lower extremity edema
Correct Answer: A, B, C, D
Rationale: Goodpasture syndrome presents with
pulmonary manifestations (hemoptysis, dyspnea) and
renal manifestations (rapidly progressive kidney
failure, proteinuria, edema).
4. What does the mnemonic SOAP BRAIN MD
represent?
,A) Treatment algorithm for rheumatoid arthritis
B) Diagnostic criteria for systemic lupus
erythematosus
C) Contraindications for hormone therapy
D) Risk factors for osteoporosis
Correct Answer: B
Rationale: SOAP BRAIN MD is a mnemonic for the
diagnostic criteria of systemic lupus erythematosus:
Serositis, Oral/nasal ulcers, Arthritis,
Photosensitivity, Blood disorders, Renal dysfunction,
ANA+, Immunoglobulins (anti-dsDNA), Neuro
symptoms, Malar rash, Discoid rash.
5. What is porphyria?
A) A bacterial skin infection caused by
Staphylococcus
B) A sunlight sensitivity disorder causing allergy to
UV rays
C) An autoimmune blistering disease
D) A fungal infection of the nails
Correct Answer: B
Rationale: Porphyria is a disorder of heme
biosynthesis that causes photosensitivity, making
, affected individuals allergic or sensitive to ultraviolet
rays.
6. What is the characteristic imaging finding in
pulmonary anthrax?
A) Bilateral hilar lymphadenopathy
B) Widened mediastinum
C) Cavitary lung lesions
D) Pleural effusion with air trapping
Correct Answer: B
Rationale: Pulmonary anthrax classically presents
with a widened mediastinum on chest imaging due to
hemorrhagic mediastinitis.
7. What is aortocaval compression?
A) Compression of the aorta and vena cava by a
thoracic aneurysm
B) Compression of the aorta and vena cava by the
gravid uterus in the supine pregnant patient
C) Congenital narrowing of the aorta and vena cava
D) Compression of the aorta and vena cava by a
retroperitoneal tumor
Correct Answer: B
