Page 1 of 160
COMSAE Phase 1 Form 114 exam COMPLETE
QUESTIONS AND DETAILED SOLUTIONS LATEST
UPDATE THIS YEAR-JUST RELEASED
COMSAE Phase 1 Form 114
1.
A 62-year-old man with long-term smoking presents with painless gross hematuria and a bladder mass
on imaging. What is the most likely diagnosis?
A. Renal cell carcinoma
B. Urothelial carcinoma
C. Prostate adenocarcinoma
D. Renal stone disease
Answer: B. Urothelial carcinoma
Rationale: Smoking is the strongest risk factor for transitional (urothelial) cell carcinoma of bladder.
2.
, Page 2 of 160
A patient presents with fever, flank pain, dysuria, and costovertebral angle tenderness on examination.
What is the most likely diagnosis?
A. Cystitis
B. Pyelonephritis
C. Urethritis
D. Interstitial nephritis
Answer: B. Pyelonephritis
Rationale: Fever + CVA tenderness indicates upper urinary tract infection.
3.
A child presents with slapped-cheek rash after mild prodromal flu-like illness. Which virus is responsible?
A. Epstein-Barr virus
B. Parvovirus B19
C. Rubella virus
D. Measles virus
, Page 3 of 160
Answer: B. Parvovirus B19
Rationale: Causes erythema infectiosum (fifth disease).
4.
A patient has microcytic anemia with target cells and abnormal hemoglobin electrophoresis. What is the
most likely diagnosis?
A. Iron deficiency anemia
B. Thalassemia
C. Sideroblastic anemia
D. Lead poisoning
Answer: B. Thalassemia
Rationale: Defective globin chain synthesis causes target cells.
5.
, Page 4 of 160
A newborn presents with respiratory distress shortly after birth and ground-glass appearance on chest
X-ray. What is the diagnosis?
A. Meconium aspiration syndrome
B. Neonatal respiratory distress syndrome
C. Pneumonia
D. Congenital diaphragmatic hernia
Answer: B. Neonatal respiratory distress syndrome
Rationale: Surfactant deficiency in premature infants.
6.
A hypertensive patient presents with sudden tearing chest pain radiating to the back. What is the most
likely diagnosis?
A. Myocardial infarction
B. Aortic dissection
COMSAE Phase 1 Form 114 exam COMPLETE
QUESTIONS AND DETAILED SOLUTIONS LATEST
UPDATE THIS YEAR-JUST RELEASED
COMSAE Phase 1 Form 114
1.
A 62-year-old man with long-term smoking presents with painless gross hematuria and a bladder mass
on imaging. What is the most likely diagnosis?
A. Renal cell carcinoma
B. Urothelial carcinoma
C. Prostate adenocarcinoma
D. Renal stone disease
Answer: B. Urothelial carcinoma
Rationale: Smoking is the strongest risk factor for transitional (urothelial) cell carcinoma of bladder.
2.
, Page 2 of 160
A patient presents with fever, flank pain, dysuria, and costovertebral angle tenderness on examination.
What is the most likely diagnosis?
A. Cystitis
B. Pyelonephritis
C. Urethritis
D. Interstitial nephritis
Answer: B. Pyelonephritis
Rationale: Fever + CVA tenderness indicates upper urinary tract infection.
3.
A child presents with slapped-cheek rash after mild prodromal flu-like illness. Which virus is responsible?
A. Epstein-Barr virus
B. Parvovirus B19
C. Rubella virus
D. Measles virus
, Page 3 of 160
Answer: B. Parvovirus B19
Rationale: Causes erythema infectiosum (fifth disease).
4.
A patient has microcytic anemia with target cells and abnormal hemoglobin electrophoresis. What is the
most likely diagnosis?
A. Iron deficiency anemia
B. Thalassemia
C. Sideroblastic anemia
D. Lead poisoning
Answer: B. Thalassemia
Rationale: Defective globin chain synthesis causes target cells.
5.
, Page 4 of 160
A newborn presents with respiratory distress shortly after birth and ground-glass appearance on chest
X-ray. What is the diagnosis?
A. Meconium aspiration syndrome
B. Neonatal respiratory distress syndrome
C. Pneumonia
D. Congenital diaphragmatic hernia
Answer: B. Neonatal respiratory distress syndrome
Rationale: Surfactant deficiency in premature infants.
6.
A hypertensive patient presents with sudden tearing chest pain radiating to the back. What is the most
likely diagnosis?
A. Myocardial infarction
B. Aortic dissection
