COMSAE Phase 1 Form 115 Practice
Exam | Questions And Answers [ plus
Rationales] | Qs & Ans 2026/27 |
Graded A
1. A 55-year-old man presents with crushing chest pain radiating to his left
arm. ECG shows ST elevation in leads II, III, and aVF. Which coronary artery is
most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Answer: C. Right coronary artery
Rationale: Inferior wall MI (II, III, aVF) is most commonly due to RCA
occlusion.
2. Which enzyme is elevated earliest after myocardial infarction?
A. Troponin I
B. CK-MB
C. AST
D. LDH
Answer: B. CK-MB
Rationale: CK-MB rises within 3–6 hours and is useful for early detection of
reinfarction.
3. A child presents with fever, sore throat, and a sandpaper rash. What is the
most likely causative organism?
A. Staphylococcus aureus
B. Streptococcus pyogenes
,C. Corynebacterium diphtheriae
D. Epstein-Barr virus
Answer: B. Streptococcus pyogenes
Rationale: Scarlet fever is caused by Group A Streptococcus producing
erythrogenic toxin.
4. Which vitamin deficiency causes scurvy?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
Answer: C. Vitamin C
Rationale: Vitamin C is required for collagen synthesis; deficiency causes
bleeding gums and poor wound healing.
5. A patient has tremor, weight loss, and exophthalmos. What antibody is
most likely elevated?
A. Anti-TPO
B. Anti-TSH receptor antibody
C. Anti-thyroglobulin
D. Anti-mitochondrial antibody
Answer: B. Anti-TSH receptor antibody
Rationale: Graves disease is caused by TSH receptor–stimulating antibodies.
6. Which structure is derived from the mesoderm?
A. Epidermis
B. Central nervous system
C. Skeletal muscle
D. Lens of eye
Answer: C. Skeletal muscle
Rationale: Mesoderm forms muscle, bone, and connective tissue.
7. A patient with COPD has elevated PaCO₂. What is the primary
compensatory mechanism?
, A. Respiratory alkalosis
B. Metabolic alkalosis
C. Renal bicarbonate retention
D. Increased aldosterone secretion
Answer: C. Renal bicarbonate retention
Rationale: Kidneys compensate for chronic respiratory acidosis by retaining
bicarbonate.
8. Which type of hypersensitivity is seen in transfusion reactions?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: B. Type II
Rationale: Type II hypersensitivity involves antibody-mediated cytotoxicity.
9. A newborn presents with cataracts, deafness, and PDA. What infection is
most likely?
A. Toxoplasmosis
B. Rubella
C. CMV
D. Syphilis
Answer: B. Rubella
Rationale: Congenital rubella syndrome causes cataracts, PDA, and
sensorineural deafness.
10. Which cell type produces insulin?
A. Alpha cells
B. Beta cells
C. Delta cells
D. PP cells
Answer: B. Beta cells
Rationale: Pancreatic beta cells in the islets of Langerhans secrete insulin.
11. Which drug is used as an antidote for acetaminophen overdose?
Exam | Questions And Answers [ plus
Rationales] | Qs & Ans 2026/27 |
Graded A
1. A 55-year-old man presents with crushing chest pain radiating to his left
arm. ECG shows ST elevation in leads II, III, and aVF. Which coronary artery is
most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Answer: C. Right coronary artery
Rationale: Inferior wall MI (II, III, aVF) is most commonly due to RCA
occlusion.
2. Which enzyme is elevated earliest after myocardial infarction?
A. Troponin I
B. CK-MB
C. AST
D. LDH
Answer: B. CK-MB
Rationale: CK-MB rises within 3–6 hours and is useful for early detection of
reinfarction.
3. A child presents with fever, sore throat, and a sandpaper rash. What is the
most likely causative organism?
A. Staphylococcus aureus
B. Streptococcus pyogenes
,C. Corynebacterium diphtheriae
D. Epstein-Barr virus
Answer: B. Streptococcus pyogenes
Rationale: Scarlet fever is caused by Group A Streptococcus producing
erythrogenic toxin.
4. Which vitamin deficiency causes scurvy?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
Answer: C. Vitamin C
Rationale: Vitamin C is required for collagen synthesis; deficiency causes
bleeding gums and poor wound healing.
5. A patient has tremor, weight loss, and exophthalmos. What antibody is
most likely elevated?
A. Anti-TPO
B. Anti-TSH receptor antibody
C. Anti-thyroglobulin
D. Anti-mitochondrial antibody
Answer: B. Anti-TSH receptor antibody
Rationale: Graves disease is caused by TSH receptor–stimulating antibodies.
6. Which structure is derived from the mesoderm?
A. Epidermis
B. Central nervous system
C. Skeletal muscle
D. Lens of eye
Answer: C. Skeletal muscle
Rationale: Mesoderm forms muscle, bone, and connective tissue.
7. A patient with COPD has elevated PaCO₂. What is the primary
compensatory mechanism?
, A. Respiratory alkalosis
B. Metabolic alkalosis
C. Renal bicarbonate retention
D. Increased aldosterone secretion
Answer: C. Renal bicarbonate retention
Rationale: Kidneys compensate for chronic respiratory acidosis by retaining
bicarbonate.
8. Which type of hypersensitivity is seen in transfusion reactions?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: B. Type II
Rationale: Type II hypersensitivity involves antibody-mediated cytotoxicity.
9. A newborn presents with cataracts, deafness, and PDA. What infection is
most likely?
A. Toxoplasmosis
B. Rubella
C. CMV
D. Syphilis
Answer: B. Rubella
Rationale: Congenital rubella syndrome causes cataracts, PDA, and
sensorineural deafness.
10. Which cell type produces insulin?
A. Alpha cells
B. Beta cells
C. Delta cells
D. PP cells
Answer: B. Beta cells
Rationale: Pancreatic beta cells in the islets of Langerhans secrete insulin.
11. Which drug is used as an antidote for acetaminophen overdose?
