NSG 211: Immunity/SLE/Anaphylaxis Exam
With Complete Solutions
systemic lupus erythematosus - ANSWER inflammatory, autoimmune disorder
that affects nearly every organ in the body
-Has remission and exacerbations
-Early detection improves outcomes
Who does SLE most commonly occur in? - ANSWER Women and African
Americans
Forms of SLE - ANSWER Discoid Lupus Erythematosus: primarily skin and on
face
Subacute Cutaneous Lupus Erythematous: exposed areas that are infected with
sores
Drug-Induced Lupus: rarely includes brain or kidney effects and is usually
temporary
SLE Risk Factors - ANSWER -Females age 20-40 years old
-Race: African American, Hispanic, Asian, Native American
-Combination of genetic and environmental factors
-Family history
-Physical or mental stress
-Streptococcal or viral infections
-Exposure to sunlight
-Injury, surgery, pregnancy
-Abnormal estrogen metabolism
-Treatment with: sulfa drugs, PCN, hydralazine, antibiotics
Clinical Manifestations of SLE: - ANSWER -Acute or chronic
-Fever
-Malaise/Fatigue
-Anorexia
-Mucuocutaneous, musculoskeletal, renal, nervous, cardiovascular, and
respiratory symptoms (80-90% of patients)
-Butterfly-shaped erythematous rash across the bridge of the nose and cheeks
most familiar
-Oral ulcers, splinter hemorrhages, alopecia, blurred vision, pleuritic pain,
Raynaud's phenomenon
SLE Assessment - ANSWER History and physical
Tests: anti-DNA (antibody that develops against the patient's own DNA)
-Anti-ds DNA (antibody against dNA that is highly specific to SLE, which
differentiates between drug-induced lupus)
With Complete Solutions
systemic lupus erythematosus - ANSWER inflammatory, autoimmune disorder
that affects nearly every organ in the body
-Has remission and exacerbations
-Early detection improves outcomes
Who does SLE most commonly occur in? - ANSWER Women and African
Americans
Forms of SLE - ANSWER Discoid Lupus Erythematosus: primarily skin and on
face
Subacute Cutaneous Lupus Erythematous: exposed areas that are infected with
sores
Drug-Induced Lupus: rarely includes brain or kidney effects and is usually
temporary
SLE Risk Factors - ANSWER -Females age 20-40 years old
-Race: African American, Hispanic, Asian, Native American
-Combination of genetic and environmental factors
-Family history
-Physical or mental stress
-Streptococcal or viral infections
-Exposure to sunlight
-Injury, surgery, pregnancy
-Abnormal estrogen metabolism
-Treatment with: sulfa drugs, PCN, hydralazine, antibiotics
Clinical Manifestations of SLE: - ANSWER -Acute or chronic
-Fever
-Malaise/Fatigue
-Anorexia
-Mucuocutaneous, musculoskeletal, renal, nervous, cardiovascular, and
respiratory symptoms (80-90% of patients)
-Butterfly-shaped erythematous rash across the bridge of the nose and cheeks
most familiar
-Oral ulcers, splinter hemorrhages, alopecia, blurred vision, pleuritic pain,
Raynaud's phenomenon
SLE Assessment - ANSWER History and physical
Tests: anti-DNA (antibody that develops against the patient's own DNA)
-Anti-ds DNA (antibody against dNA that is highly specific to SLE, which
differentiates between drug-induced lupus)
