CPPS 304 EXAMPREP 2026 SOLVED
QUESTIONS FULL SOLUTION SET
◉ Pharmacokinetics. Answer: what the body does to the drug
◉ drug absoprtion. Answer: the passage of a drug from the site of
administration into the general circulation
◉ pKa. Answer: the pH at which half of the drug is ionized
◉ Bioavailability. Answer: the fraction of an orally given drug that
reaches circulation
◉ clearance. Answer: the volume of blood from which a drug is
irreversibly removed per unit of time
◉ volume of distribution. Answer: a theoretical volume in which the
total amount of administered drug should be uniformly distributed t
account for its plasma or blood concentration
◉ half-life. Answer: the time it takes for half of the drug to be
metabolized by 50%
◉ ion-trapping. Answer: acidic drug accumulates on the more basic side
and a basic drug accumulates on the more acidic side
, ◉ An acidic drug become more ionized in ______ medium. Answer: a
basic
◉ A basic drug becomes more ionized in ______ medium. Answer: an
acidic
◉ first pass metabolism. Answer: Phenomenon in which the liver
metabolizes some of a drug before it can circulate through the body,
particularly when the drug has been taken orally.
◉ High Vd. Answer: most of the drug is in the extravascular
compartment
◉ Low Vd. Answer: most of the drug is in the vascular compartment
(the blood vessel)
◉ Drug metabolism. Answer: chemical modification of drug enzymes,
to make them more poalr, and therefore readily excretable by the
kidneys
◉ Phase 1 metabolism. Answer: Oxidation, reduction, hydrolysis; makes
the drug more polar
◉ Phase 2 metabolism. Answer: Conjugation reactions to polar groups;
drug inactivation and rapid excretion
QUESTIONS FULL SOLUTION SET
◉ Pharmacokinetics. Answer: what the body does to the drug
◉ drug absoprtion. Answer: the passage of a drug from the site of
administration into the general circulation
◉ pKa. Answer: the pH at which half of the drug is ionized
◉ Bioavailability. Answer: the fraction of an orally given drug that
reaches circulation
◉ clearance. Answer: the volume of blood from which a drug is
irreversibly removed per unit of time
◉ volume of distribution. Answer: a theoretical volume in which the
total amount of administered drug should be uniformly distributed t
account for its plasma or blood concentration
◉ half-life. Answer: the time it takes for half of the drug to be
metabolized by 50%
◉ ion-trapping. Answer: acidic drug accumulates on the more basic side
and a basic drug accumulates on the more acidic side
, ◉ An acidic drug become more ionized in ______ medium. Answer: a
basic
◉ A basic drug becomes more ionized in ______ medium. Answer: an
acidic
◉ first pass metabolism. Answer: Phenomenon in which the liver
metabolizes some of a drug before it can circulate through the body,
particularly when the drug has been taken orally.
◉ High Vd. Answer: most of the drug is in the extravascular
compartment
◉ Low Vd. Answer: most of the drug is in the vascular compartment
(the blood vessel)
◉ Drug metabolism. Answer: chemical modification of drug enzymes,
to make them more poalr, and therefore readily excretable by the
kidneys
◉ Phase 1 metabolism. Answer: Oxidation, reduction, hydrolysis; makes
the drug more polar
◉ Phase 2 metabolism. Answer: Conjugation reactions to polar groups;
drug inactivation and rapid excretion
