Class notes NUR 2407

NERVOUS SYSTEM Benzodiazepines • Alprazolam • Diazepam • Lorazepam • Chlordiazepoxide • Sedation • Dependency/Withdrawal - Short term • Antidote is Flumazenil Atypical Anxiolytics • Buspirone • No Sedation - No Dependency - Long term • Full effects take weeks • Take with meals SSRIs • Paroxetine • Sertraline • Fluoxetine • Insomnia • Watch for Serotonin Syndrome (Agitation, Hallucinations, Fever, Diaphoresis, Tremors) • Do Not Take With St. John’s Wort • Full Effects take months Atypical Antidepressants • Bupropion • Trazodone (Major Side Effect - Sedation) • Depression & Smoke Cessation • Insomnia, headache, GI Distress, Weight Loss, Agitation, Seizures TCAs • Amitriptyline • Imipramine • Sedation, orthostatic hypotension Anticholinergic Effects (Urinary Retention, Constipation, Dry Mouth, Blurry Vision, Photophobia) MAOIs • Phenelzine • Tranylcypromine • HTN Crisis • Do not eat foods with tyramine Mood Stabilizers • Lithium • Side Effects: GI Upset, Fine Hand Tremors (Coarse in Tox), Polyuria, Weight gain, Kidney Tox, Electrolyte imbalances • Monitor Plasma Levels: Tox over 1.5 mEq/L • Toxicity (Coarse hand tremors, confusion, hypotension, seizures, tinnitus • No diuretics, Anticholinergics or NSAIDs • Contraindicated in Renal Disease • Closely monitor NA, Drink 2-3 L of water Antiepileptics (Bipolar Disorder) • Carbamazepine (Blood Issues (Anemia, Thrombocytopenia & Leukopenia), Vision Issues & Rash) • Valproic Acid (GI Upset, Hepatotoxicity, Pancreatitis, Thrombocytopenia) Antipsychotics • Chlorpromazine • Haloperidol • EPS, NMS, Agranulocytosis, Anticholinergic Effects, Sedation ...................................CONTINUED........................................