NSG552 EXAM 1 COMPREHENSIVE FINAL
PAPER 2026 FULL SOLUTION STUDY GUIDE
◉ A chemical that binds to a receptor but does not fully activate the
receptor. Answer: partial agonist
◉ A chemical that binds to a receptor, blocking it to inhibit a biologic
response. Answer: Antagonist
◉ An agent that binds to the same receptor as an agonist but
induces an opposite biological response. Answer: inverse agonist
◉ A usually undesired but forseeable effect that occurs regardless of
dose and often resolves after continued therapy. Answer: side effect
◉ S/S opposite of what it was meant to treat:. Answer: paradoxical
reaction
◉ CYP450 interactions are part of:. Answer: Metabolism
◉ Escitalopram is a CYP450-3A4 substrate. If the PMHNP adds a
second medication that is a 3A4 inducer, what happens to the
escitalopram levels?. Answer: They decrease
,◉ Binding. Answer: A protein, macromolecule, nucleic acid, or small
molecule to which a given drug binds, resulting in an alteration of
the normal function of the bound molecule and a desirable
therapeutic effect.
◉ Affinity. Answer: the extent or fraction to which a drug binds to
receptors at any given drug concentration
◉ CYP450. Answer: Cytochrome P450 (CYP450), a large superfamily
of heme-thiolate proteins, are involved in the metabolism of both
exogenous and endogenous compounds
◉ Symptoms of schizophrenia are divided into these two categories:.
Answer: Positive and negative
◉ T/F Antipsychotic polypharmacy can increase the risk of re-
hospitalization, diabetes, EPS, sedation, seizures, metabolic effects,
mortality, and sudden cardiac death.. Answer: T
◉ Alogia, anhedonia, avolition and cognitive symptoms:. Answer:
Negative symptoms
◉ Delusions, hallucinations, hostility, grandiosity:. Answer: Positive
Symptoms
, ◉ Another name for 1st generation antipsychotics:. Answer: Typical
antipsychotics, FGA
◉ Another name for 2nd generation antipsychotics:. Answer:
Atypical antipsychotics, SGA
◉ First line treatment for Schizophrenia:. Answer: Second-
generation antipsychotics (except clozapine)
◉ This class is associated with fewer neurological side effects and
effective for both positive and negative symptoms:. Answer: Second-
generation antipsychotics
◉ This class is effective for only positive symptoms and can in fact
worsen negative symptoms due to decreased DA in the mesocortical
pathway:. Answer: First generation antipsychotics
◉ Associated with metabolic side effects:. Answer: Second-
generation antipsychotics
◉ What are the metabolic side effects associated Atypical
antipsychotics:. Answer: Hyperglycemia, glucose disregulation, lipid
disturbance. Leading to HTN/DMII/metabolic d/o
PAPER 2026 FULL SOLUTION STUDY GUIDE
◉ A chemical that binds to a receptor but does not fully activate the
receptor. Answer: partial agonist
◉ A chemical that binds to a receptor, blocking it to inhibit a biologic
response. Answer: Antagonist
◉ An agent that binds to the same receptor as an agonist but
induces an opposite biological response. Answer: inverse agonist
◉ A usually undesired but forseeable effect that occurs regardless of
dose and often resolves after continued therapy. Answer: side effect
◉ S/S opposite of what it was meant to treat:. Answer: paradoxical
reaction
◉ CYP450 interactions are part of:. Answer: Metabolism
◉ Escitalopram is a CYP450-3A4 substrate. If the PMHNP adds a
second medication that is a 3A4 inducer, what happens to the
escitalopram levels?. Answer: They decrease
,◉ Binding. Answer: A protein, macromolecule, nucleic acid, or small
molecule to which a given drug binds, resulting in an alteration of
the normal function of the bound molecule and a desirable
therapeutic effect.
◉ Affinity. Answer: the extent or fraction to which a drug binds to
receptors at any given drug concentration
◉ CYP450. Answer: Cytochrome P450 (CYP450), a large superfamily
of heme-thiolate proteins, are involved in the metabolism of both
exogenous and endogenous compounds
◉ Symptoms of schizophrenia are divided into these two categories:.
Answer: Positive and negative
◉ T/F Antipsychotic polypharmacy can increase the risk of re-
hospitalization, diabetes, EPS, sedation, seizures, metabolic effects,
mortality, and sudden cardiac death.. Answer: T
◉ Alogia, anhedonia, avolition and cognitive symptoms:. Answer:
Negative symptoms
◉ Delusions, hallucinations, hostility, grandiosity:. Answer: Positive
Symptoms
, ◉ Another name for 1st generation antipsychotics:. Answer: Typical
antipsychotics, FGA
◉ Another name for 2nd generation antipsychotics:. Answer:
Atypical antipsychotics, SGA
◉ First line treatment for Schizophrenia:. Answer: Second-
generation antipsychotics (except clozapine)
◉ This class is associated with fewer neurological side effects and
effective for both positive and negative symptoms:. Answer: Second-
generation antipsychotics
◉ This class is effective for only positive symptoms and can in fact
worsen negative symptoms due to decreased DA in the mesocortical
pathway:. Answer: First generation antipsychotics
◉ Associated with metabolic side effects:. Answer: Second-
generation antipsychotics
◉ What are the metabolic side effects associated Atypical
antipsychotics:. Answer: Hyperglycemia, glucose disregulation, lipid
disturbance. Leading to HTN/DMII/metabolic d/o
