NR566 ADVANCED PHARMACOLOGY MIDTERM STUDY
GUIDE QUICK CRAM COMPLETE SOLUTIONS ~
CHAMBERLAIN UNIVERSITY
NR566 – Advanced Pharmacology Midterm Study Guide (Answer Summary)
Week 1 – Fungal & Viral Infections
Fungal infections: Caused by dermatophytes, yeasts (Candida), or molds. Treatment depends on
infection location and severity.
Griseofulvin: Used for dermatophyte infections of hair, skin, and nails. Works by inhibiting fungal cell
mitosis.
Terbinafine: Indicated for onychomycosis and tinea infections. Adverse effects include hepatotoxicity,
GI upset, rash, and taste disturbances.
Amphotericin B: Major adverse effects include nephrotoxicity, hypokalemia, fever, chills, and infusion
reactions.
Acyclovir: Inhibits viral DNA polymerase to prevent viral replication.
Valacyclovir: Used for herpes simplex, genital herpes, and herpes zoster.
Ganciclovir: Used for CMV infections. Adverse effects include bone marrow suppression and
neutropenia.
Docosanol: Topical medication for herpes labialis (cold sores).
Oseltamivir: Neuraminidase inhibitor used to treat influenza A and B.
Week 2 – Bacterial Infections
Sulfonamides MOA: Inhibit bacterial folic acid synthesis.
Penicillin MOA: Inhibits bacterial cell wall synthesis.
Aminoglycosides MOA: Bind to the 30S ribosomal subunit and disrupt protein synthesis, leading to
bacterial death.
Community-acquired pneumonia: First line treatments include amoxicillin, doxycycline, or macrolides.
Penicillin G: Used for severe infections including syphilis.
Amoxicillin: Used for otitis media, sinusitis, strep throat, and pneumonia.
Carbapenems: Broad spectrum antibiotics that inhibit bacterial cell wall synthesis.
Clindamycin: Inhibits protein synthesis by binding to the 50S ribosomal subunit. Risk of C. difficile
infection.
Gentamicin: Adverse effects include nephrotoxicity and ototoxicity.
Nitrofurantoin: Used for uncomplicated UTIs. Avoid if creatinine clearance <30.
GUIDE QUICK CRAM COMPLETE SOLUTIONS ~
CHAMBERLAIN UNIVERSITY
NR566 – Advanced Pharmacology Midterm Study Guide (Answer Summary)
Week 1 – Fungal & Viral Infections
Fungal infections: Caused by dermatophytes, yeasts (Candida), or molds. Treatment depends on
infection location and severity.
Griseofulvin: Used for dermatophyte infections of hair, skin, and nails. Works by inhibiting fungal cell
mitosis.
Terbinafine: Indicated for onychomycosis and tinea infections. Adverse effects include hepatotoxicity,
GI upset, rash, and taste disturbances.
Amphotericin B: Major adverse effects include nephrotoxicity, hypokalemia, fever, chills, and infusion
reactions.
Acyclovir: Inhibits viral DNA polymerase to prevent viral replication.
Valacyclovir: Used for herpes simplex, genital herpes, and herpes zoster.
Ganciclovir: Used for CMV infections. Adverse effects include bone marrow suppression and
neutropenia.
Docosanol: Topical medication for herpes labialis (cold sores).
Oseltamivir: Neuraminidase inhibitor used to treat influenza A and B.
Week 2 – Bacterial Infections
Sulfonamides MOA: Inhibit bacterial folic acid synthesis.
Penicillin MOA: Inhibits bacterial cell wall synthesis.
Aminoglycosides MOA: Bind to the 30S ribosomal subunit and disrupt protein synthesis, leading to
bacterial death.
Community-acquired pneumonia: First line treatments include amoxicillin, doxycycline, or macrolides.
Penicillin G: Used for severe infections including syphilis.
Amoxicillin: Used for otitis media, sinusitis, strep throat, and pneumonia.
Carbapenems: Broad spectrum antibiotics that inhibit bacterial cell wall synthesis.
Clindamycin: Inhibits protein synthesis by binding to the 50S ribosomal subunit. Risk of C. difficile
infection.
Gentamicin: Adverse effects include nephrotoxicity and ototoxicity.
Nitrofurantoin: Used for uncomplicated UTIs. Avoid if creatinine clearance <30.
