APHON EXAM PRACTICE QUESTIONS FOR ACTUAL EXAMS AND
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CORE DOMAINS:
Hematologic Disorders (Anemias, Hemoglobinopathies, Coagulation Disorders)
Pediatric Cancers (Leukemias, Lymphomas, Solid Tumors, CNS Tumors)
Treatment Modalities (Chemotherapy, Biotherapy, Radiation, Surgery)
Hematopoietic Stem Cell Transplantation
Supportive Care and Symptom Management
Psychosocial and Palliative Care
Professional Practice and Education
The following practice exam is designed for pediatric oncology and hematology
nursing professionals preparing for the APHON certification. It reflects advanced
clinical scenarios, evidence-based interventions, and critical decision-making
required in the specialized care of children and adolescents with cancer and blood
disorders.
SECTION 1: Questions
1. A 4-year-old child with Wilms tumor presents with sudden onset hypertension and
hematuria. What is the most likely physiological cause related to the tumor's
location?
ANS: Renal artery compression or increased renin production
,2. Which laboratory value is the most critical indicator of tumor lysis syndrome risk
in a patient newly diagnosed with Burkitt lymphoma?
ANS: Uric acid level
3. A patient receiving vincristine is experiencing severe jaw pain and constipation.
These symptoms are characteristic of which type of toxicity?
ANS: Neurotoxicity
4. What is the primary reason for administering mesna (sodium 2-mercaptoethane
sulfonate) during high-dose cyclophosphamide therapy?
ANS: To prevent hemorrhagic cystitis
5. In a child with Sickle Cell Disease, a sudden drop in hemoglobin accompanied by
a low reticulocyte count is most suggestive of which complication?
ANS: Aplastic crisis
6. Which pediatric brain tumor is most commonly found in the posterior fossa and
can cause obstructive hydrocephalus?
ANS: Medulloblastoma
7. During a blood transfusion, a patient develops chills, fever, and lumbar pain. What
is the immediate nursing priority?
ANS: Stop the transfusion
8. What is the gold standard for diagnosing a definitive case of neuroblastoma in a
toddler?
, ANS: Tissue biopsy and urinary catecholamine levels (VMA/HVA)
9. A child undergoing hematopoietic stem cell transplant (HSCT) develops right
upper quadrant pain, weight gain, and jaundice. These are classic signs of what
condition?
ANS: Sinusoidal Obstruction Syndrome (Veno-occlusive disease)
10.Which medication is the preferred treatment for a pediatric patient experiencing an
anaphylactic reaction to L-asparaginase?
ANS: Epinephrine
11.A 14-year-old with Osteosarcoma is scheduled for a limb-salvage procedure. What
is the most common site of metastasis for this malignancy?
ANS: Lungs
12.What is the most appropriate nursing intervention for a neutropenic child with an
absolute neutrophil count (ANC) of 250/mm³?
ANS: Strict hand hygiene and protective isolation precautions
13.Which electrolyte imbalance is most commonly associated with the administration
of Cisplatin?
ANS: Hypomagnesemia
14.A patient with hemophilia A is bleeding into the knee joint (hemarthrosis). What is
the specific factor replacement required?
ANS: Factor VIII
100% CORRECT ANSWERS VERIFIED | FULL EXAM PREP TESTBANK
| INSTANT PDF DOWNLOAD | GUARANTEED PASS
CORE DOMAINS:
Hematologic Disorders (Anemias, Hemoglobinopathies, Coagulation Disorders)
Pediatric Cancers (Leukemias, Lymphomas, Solid Tumors, CNS Tumors)
Treatment Modalities (Chemotherapy, Biotherapy, Radiation, Surgery)
Hematopoietic Stem Cell Transplantation
Supportive Care and Symptom Management
Psychosocial and Palliative Care
Professional Practice and Education
The following practice exam is designed for pediatric oncology and hematology
nursing professionals preparing for the APHON certification. It reflects advanced
clinical scenarios, evidence-based interventions, and critical decision-making
required in the specialized care of children and adolescents with cancer and blood
disorders.
SECTION 1: Questions
1. A 4-year-old child with Wilms tumor presents with sudden onset hypertension and
hematuria. What is the most likely physiological cause related to the tumor's
location?
ANS: Renal artery compression or increased renin production
,2. Which laboratory value is the most critical indicator of tumor lysis syndrome risk
in a patient newly diagnosed with Burkitt lymphoma?
ANS: Uric acid level
3. A patient receiving vincristine is experiencing severe jaw pain and constipation.
These symptoms are characteristic of which type of toxicity?
ANS: Neurotoxicity
4. What is the primary reason for administering mesna (sodium 2-mercaptoethane
sulfonate) during high-dose cyclophosphamide therapy?
ANS: To prevent hemorrhagic cystitis
5. In a child with Sickle Cell Disease, a sudden drop in hemoglobin accompanied by
a low reticulocyte count is most suggestive of which complication?
ANS: Aplastic crisis
6. Which pediatric brain tumor is most commonly found in the posterior fossa and
can cause obstructive hydrocephalus?
ANS: Medulloblastoma
7. During a blood transfusion, a patient develops chills, fever, and lumbar pain. What
is the immediate nursing priority?
ANS: Stop the transfusion
8. What is the gold standard for diagnosing a definitive case of neuroblastoma in a
toddler?
, ANS: Tissue biopsy and urinary catecholamine levels (VMA/HVA)
9. A child undergoing hematopoietic stem cell transplant (HSCT) develops right
upper quadrant pain, weight gain, and jaundice. These are classic signs of what
condition?
ANS: Sinusoidal Obstruction Syndrome (Veno-occlusive disease)
10.Which medication is the preferred treatment for a pediatric patient experiencing an
anaphylactic reaction to L-asparaginase?
ANS: Epinephrine
11.A 14-year-old with Osteosarcoma is scheduled for a limb-salvage procedure. What
is the most common site of metastasis for this malignancy?
ANS: Lungs
12.What is the most appropriate nursing intervention for a neutropenic child with an
absolute neutrophil count (ANC) of 250/mm³?
ANS: Strict hand hygiene and protective isolation precautions
13.Which electrolyte imbalance is most commonly associated with the administration
of Cisplatin?
ANS: Hypomagnesemia
14.A patient with hemophilia A is bleeding into the knee joint (hemarthrosis). What is
the specific factor replacement required?
ANS: Factor VIII
