1. An 8-year-old patient who received an HSCT develops a grade 2 acute GVHD skin rash. The
nurse anticipates which of the following orders for initial treatment?
a. Infiximab
b. Topical steroids
c. Initiation of photopheresis
d. Increase dose of oral immunosuppressive therapy - ANSWER B. Topical steroid cream
should be used as first line therapy for grade 1 and 2 skin GVHD.
2. Cataract development post transplant is linked to which of the following treatment regi-
mens?
a. Fludarabine
b. Etoposide
c.TBI
d.Carboplatin - ANSWER C. TBI
-Patients who have received TBI are at risk for the development of cataracts.
3. Which of the following is a characteristic of stromal cells? Stromal cells:
a. differential into epithelium
b. are found in the brain
c. are responsible for immunoglobulins
1
,d. are primary location of immunoglobulins - ANSWER Answer: Bone marrow stroma is
the center of cellular activityReference: Faiman, B. (Ed.).(2016). BMTCN certification review
manual. Pittsburgh, PA: Oncology Nursing Society. p. 1-2
4. Which of the following is the first step in the pathophysiological process for acute GVHD?
a. Inflammatory effectors
b. Damage to the host tissue
c. Engraftment syndrome
d.Cytokine release syndrome - ANSWER B. Damage to the host tissue from conditioning is
the first step in the GVHD process.
5. A 45-year-old female with acute myeloid leukemia arrives for her pre-transplant evalua-
tion. The patient's twin sister offers to donate, but the physician opts to use a donor from
the National Marrow Donor Program because:
a. The patient sister is also identified as caregiver
b. the cost of immunosuppression drug is high
c.The physician prefers to use the National Marrow Donor Program
d. Syngeneic transplant increase the risk of tumor relapse - ANSWER Answer: Syngeneic
transplants do not elicit a graft versus tumor effect.
6. Annual gynecologic examinations and vaccinations against human papillomavirus are im-
portant aspects of routine health maintenance for patients following allogeneic transplant
because patients:
a. are at an increased risk of contracting sexually transmitted diseases.
b. post allogeneic transplant are at increased risk of cervical dysplasia.
c. post allogeneic transplant are at increased risk of aGVHD.
2
, d.are at increased risk for gynecomastia following transplant. - ANSWER Females who
have had an allogeneic HSCT are at an increased risk for cervical dysplasia.
7. Two hours after an HSCT infusion, a patient calls for the nurse to report red urine. What is
the most likely cause?
a.Medications given prior to transplant
b. Breakdown of red blood cells in the product
c. A low platelet count
d. Hemorrhagic cystitis - ANSWER Answer: The breakdown of red blood cells will result in
hemoglobinuria for 24 - 48 hours after infusion.
8. Which of the following is a disadvantage in the use of umbilical cord blood?
a. Cost
b. Increased risk of graft failure
c. Difficult collection process
d. Higher risk of GVHD - ANSWER Answer: Increased risk of graft failure is a disadvantage
of UCB
9. A nurse on an inpatient transplant unit reports experiencing altered sleep patterns, inabil-
ity to concentrate, feeling helpless and indifferent following the death of a patient. What is
the nurse most likely experiencing?
a. Ethical conflict
b. Moral uncertainty
c. Compassion fatigue
d. Anxiety and depression - ANSWER Answer: Compassion fatigue is defined as a person
experiencing trauma when directly caring for another person experiencing trauma.
3
nurse anticipates which of the following orders for initial treatment?
a. Infiximab
b. Topical steroids
c. Initiation of photopheresis
d. Increase dose of oral immunosuppressive therapy - ANSWER B. Topical steroid cream
should be used as first line therapy for grade 1 and 2 skin GVHD.
2. Cataract development post transplant is linked to which of the following treatment regi-
mens?
a. Fludarabine
b. Etoposide
c.TBI
d.Carboplatin - ANSWER C. TBI
-Patients who have received TBI are at risk for the development of cataracts.
3. Which of the following is a characteristic of stromal cells? Stromal cells:
a. differential into epithelium
b. are found in the brain
c. are responsible for immunoglobulins
1
,d. are primary location of immunoglobulins - ANSWER Answer: Bone marrow stroma is
the center of cellular activityReference: Faiman, B. (Ed.).(2016). BMTCN certification review
manual. Pittsburgh, PA: Oncology Nursing Society. p. 1-2
4. Which of the following is the first step in the pathophysiological process for acute GVHD?
a. Inflammatory effectors
b. Damage to the host tissue
c. Engraftment syndrome
d.Cytokine release syndrome - ANSWER B. Damage to the host tissue from conditioning is
the first step in the GVHD process.
5. A 45-year-old female with acute myeloid leukemia arrives for her pre-transplant evalua-
tion. The patient's twin sister offers to donate, but the physician opts to use a donor from
the National Marrow Donor Program because:
a. The patient sister is also identified as caregiver
b. the cost of immunosuppression drug is high
c.The physician prefers to use the National Marrow Donor Program
d. Syngeneic transplant increase the risk of tumor relapse - ANSWER Answer: Syngeneic
transplants do not elicit a graft versus tumor effect.
6. Annual gynecologic examinations and vaccinations against human papillomavirus are im-
portant aspects of routine health maintenance for patients following allogeneic transplant
because patients:
a. are at an increased risk of contracting sexually transmitted diseases.
b. post allogeneic transplant are at increased risk of cervical dysplasia.
c. post allogeneic transplant are at increased risk of aGVHD.
2
, d.are at increased risk for gynecomastia following transplant. - ANSWER Females who
have had an allogeneic HSCT are at an increased risk for cervical dysplasia.
7. Two hours after an HSCT infusion, a patient calls for the nurse to report red urine. What is
the most likely cause?
a.Medications given prior to transplant
b. Breakdown of red blood cells in the product
c. A low platelet count
d. Hemorrhagic cystitis - ANSWER Answer: The breakdown of red blood cells will result in
hemoglobinuria for 24 - 48 hours after infusion.
8. Which of the following is a disadvantage in the use of umbilical cord blood?
a. Cost
b. Increased risk of graft failure
c. Difficult collection process
d. Higher risk of GVHD - ANSWER Answer: Increased risk of graft failure is a disadvantage
of UCB
9. A nurse on an inpatient transplant unit reports experiencing altered sleep patterns, inabil-
ity to concentrate, feeling helpless and indifferent following the death of a patient. What is
the nurse most likely experiencing?
a. Ethical conflict
b. Moral uncertainty
c. Compassion fatigue
d. Anxiety and depression - ANSWER Answer: Compassion fatigue is defined as a person
experiencing trauma when directly caring for another person experiencing trauma.
3
