Transplant-related toxicity is a barrier that contributes to the under utilization for which of
the following diseases?
A. Non-Hodgkin lymphoma
B. Acute myeloid leukemia
C. Sickle cell disease
D. Neuroblastoma - ANSWER C. Sickle cell disease
Despite success of HSCT in sickle cell disease, barriers to successful HSCT include lack of a
suitable donor, transplant related toxicity and immunologic graft rejection.
Which of the following is a chemokine receptor that helps to regulate stem cell release into
the peripheral circulation?
A. CXCR4
B. CD34
C. CD14
D. CCR7 - ANSWER A. CXCR4
CXCR4 has been identified as being important in the regulation of trafficking and homing of
cells involved in hematopoiesis and the immune system.
Which of the following is a disadvantage of a syngeneic transplant?
A. Prolonged immunosuppression is required
1
,B. Limited supply of stem cells
C. Longer time to engraftment
D. Lack of graft-versus-tumor effect - ANSWER D. Lack of graft-versus-tumor effect
A syngeneic transplant lacks the graft-versus-tumor effect which is beneficial for the patient.
What is an advantage of using umbilical cord blood for an HSCT?
A. An HLA match with the recipient is not required.
B. An unlimited supply of stem cells is available.
C. The graft-versus tumor effect is avoided.
D. The cells exhibit an earlier time to engraftment. - ANSWER A. An HLA match with the
recipient is not required.
A true HLA match is not required when using umbilical cord blood because the cells have not
yet matured.
Which of the following is an advantage of using bone marrow as a source of stem cells?
A. Cells engraft more quickly
B. Takes less time to collect cells
C. Cells are more mature
D. Less risk of infection - ANSWER B. Takes less time to collect cells
Obtaining cells from the bone marrow is a much faster process than obtaining them from
the peripheral blood.
It is important to teach patients early in the transplant process to avoid contact with fresh
plants to prevent infection with:
2
, A. cytomegalovirus.
B. Pneumocystis jiroveci.
C. Aspergillus.
D. respiratory syncytial virus. - ANSWER C. Aspergillus.
Aspergillosis is primarily contracted by inhalation of aspergillus spores from fresh plants,
dried plants and moss.
Which of the following statements by a bone marrow donor indicates the need for further
teaching?
A. "I should take a warm bath to alleviate the pain after the harvest."
B. "I can expect to have some bruising at the harvest sites."
C. "I will avoid performing strenuous activities for a few days."
D. "I may require a blood transfusion during the harvest." - ANSWER A. "I should take a
warm bath to alleviate the pain after the harvest."
Due to the risk of bleeding and infection, bone marrow donors need to avoid tub baths for
several days.
Which of the following can present an ethical conflict with regard to using umbilical cord
blood for transplant?
A. The cord blood may be tested for infectious diseases.
B. Genetic diseases may be passed on to the recipient.
C. The mother may be contacted later for health information.
D. Donor families can store cells in for-profit banks. - ANSWER D. Donor families can store
cells in for-profit banks.
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the following diseases?
A. Non-Hodgkin lymphoma
B. Acute myeloid leukemia
C. Sickle cell disease
D. Neuroblastoma - ANSWER C. Sickle cell disease
Despite success of HSCT in sickle cell disease, barriers to successful HSCT include lack of a
suitable donor, transplant related toxicity and immunologic graft rejection.
Which of the following is a chemokine receptor that helps to regulate stem cell release into
the peripheral circulation?
A. CXCR4
B. CD34
C. CD14
D. CCR7 - ANSWER A. CXCR4
CXCR4 has been identified as being important in the regulation of trafficking and homing of
cells involved in hematopoiesis and the immune system.
Which of the following is a disadvantage of a syngeneic transplant?
A. Prolonged immunosuppression is required
1
,B. Limited supply of stem cells
C. Longer time to engraftment
D. Lack of graft-versus-tumor effect - ANSWER D. Lack of graft-versus-tumor effect
A syngeneic transplant lacks the graft-versus-tumor effect which is beneficial for the patient.
What is an advantage of using umbilical cord blood for an HSCT?
A. An HLA match with the recipient is not required.
B. An unlimited supply of stem cells is available.
C. The graft-versus tumor effect is avoided.
D. The cells exhibit an earlier time to engraftment. - ANSWER A. An HLA match with the
recipient is not required.
A true HLA match is not required when using umbilical cord blood because the cells have not
yet matured.
Which of the following is an advantage of using bone marrow as a source of stem cells?
A. Cells engraft more quickly
B. Takes less time to collect cells
C. Cells are more mature
D. Less risk of infection - ANSWER B. Takes less time to collect cells
Obtaining cells from the bone marrow is a much faster process than obtaining them from
the peripheral blood.
It is important to teach patients early in the transplant process to avoid contact with fresh
plants to prevent infection with:
2
, A. cytomegalovirus.
B. Pneumocystis jiroveci.
C. Aspergillus.
D. respiratory syncytial virus. - ANSWER C. Aspergillus.
Aspergillosis is primarily contracted by inhalation of aspergillus spores from fresh plants,
dried plants and moss.
Which of the following statements by a bone marrow donor indicates the need for further
teaching?
A. "I should take a warm bath to alleviate the pain after the harvest."
B. "I can expect to have some bruising at the harvest sites."
C. "I will avoid performing strenuous activities for a few days."
D. "I may require a blood transfusion during the harvest." - ANSWER A. "I should take a
warm bath to alleviate the pain after the harvest."
Due to the risk of bleeding and infection, bone marrow donors need to avoid tub baths for
several days.
Which of the following can present an ethical conflict with regard to using umbilical cord
blood for transplant?
A. The cord blood may be tested for infectious diseases.
B. Genetic diseases may be passed on to the recipient.
C. The mother may be contacted later for health information.
D. Donor families can store cells in for-profit banks. - ANSWER D. Donor families can store
cells in for-profit banks.
3
