ANCC AGPCNP Practice Qs Questions and Answers Updated 2026

ANCC AGPCNP Practice Qs
Questions and Answers Updated
2026
AnM18-year-
oldMfemaleMpatientMisMbeingMfollowedMupMforMacneMbyMtheMnurseMpractitioner.MDurin
gMtheMfacialMexam,MpapulesMandMpustulesMareMnotedMmostlyMonMtheMforeheadMandMt
heMchinMareas.MTheMpatientMhasMbeenMusingMover-the-
counterMtopicalMantibioticMgelsMandMmedicatedMsoapMdailyMforM6MmonthsMwithoutMmu
chMimprovement.MTheMnurseMpractitionerMwillMrecommend:



a.MIsotretinoinM(Accutane)

b.MTetracyclineM(Sumycin)

c.MClindamycinMtopicalMsolutionM(Cleocin-MT)

d.MMinoxidilM(Rogaine)M-MAnswerMb.MTetracyclineM(Sumycin)



First-lineMtreatmentMforMacneMvulgarisMincludesMover-the-
counterMmedicatedMsoapMandMwaterMwithMtopicalMantibioticMgels.MTheMnextMstepMinMt
reatmentMwouldMbeMtheMinitiationMofMoralMtetracycline.



AMyoungMadultMpresentsMforMreassessmentMofMuncontrolledMasthmaMsymptoms.MTheMpa
tientMisMcurrentlyMtakingManMinhaledMshort-actingMbeta2-
agonistM(SABA)MasMneededMandMreportsMdaytimeMsymptomsMmoreMthanM3Mdays/week,
MbutMnotMdaily,MandMnighttimeMawakeningsM4MtoM5Mtimes/week.MTheMpatient'sMforced
MexpiratoryMvolumeM(FEV1)MisM80%MofMpredicted.MTheMnurseMpractitionerMupgradesMth
eMpatientMtoMtheMnextMstageMofMtreatment,MwhichMincludes:



a.MBudesonideMwithMformoterol

b.MBudesonideMwithMmontelukast

c.MCromolynMorMnedocromil

d.MFluticasoneMwithMsalmeterolM-MAnswerMa.MBudesonideMwithMformoterol.



TheMpatientMhasMmovedMfromMstepM2MtoMstepM3MonMtheMasthmaMclassificationMscale.
MTherefore,MaMlow-doseMinhaledMcorticosteroidM(ICS)MplusMlong-actingMbeta-
agonistM(LABA)MsuchMasMbudesonideMwithMformoterolMisManMappropriateMstartingMpoint.
MFluticasoneMwithMsalmeterolMisMprescribedMifMtheMpatientMisMatMstepM4;Mbudesonide

,MwithMmontelukastMisManMalternative.MCromolynMandMnedocromilMhaveMbeenMdiscontinu
edMinMtheMUnitedMStates.



WhichMofMtheMfollowingMdrugsMcanMincreaseMtheMriskMofMbleedingMinMpatientsMwhoMa
reMreceivingManticoagulationMtherapyMwithMwarfarinMsodiumM(Coumadin)?



a.MTrimethoprim-sulfamethoxazoleM(BactrimMDS)

b.MCarafateM(Sucralfate)

c.MLosartanM(Cozaar)

d.MFurosemideM(Lasix)M-MAnswerMa.MTrimethoprim-sulfamethoxazoleM(BactrimMDS).



WarfarinMsodiumM(Coumadin)MinteractsMwithMBactrimMandMwillMincreaseMtheMriskMofMbl
eeding;Mtherefore,MconcurrentMuseMisMcontraindicated.



AM22-year-oldMwomanMisMgoingMonMaM5-
dayMcruiseMforMherMhoneymoon.MSheMreportsMaMhistoryMofMsevereMmotionMsickness.M
WhichMofMtheMfollowingMmedicinesMcanMbeMprescribedMforMmotionMsickness?



a.MDimenhydrinateM(Dramamine)

b.MMetoclopramideM(Reglan)

c.MOndansetronM(Zofran)

d.MScopolamineMpatchM(TransdermMScop)M-
MAnswerMd.MScopolamineMpatchM(TransdermMScop)



ScopolamineMpatchM(TransdermMScop)MisMaMprescriptionMmedicineMthatMisMusedMforMm
otion/seaMsickness.MItMisMaMsmall,McircularMpatchMthatMisMplacedMbehindMtheMearMand
MisMeffectiveMforM3Mdays.MAdviseMtheMpatientMtoMapplyMitM4MhoursMbeforeMtheMtrip
MtoMbeMeffective.MBecauseMtheMquestionMisMaskingMaboutMaM"prescribed"Mmedication,
ManMover-the-
counterM(OTC)Mmedicine,MsuchMasMDramamine,MisManMincorrectMresponse.MZofranMisMin
dicatedMforMcancer-relatedMnauseaMandMvomitingM(chemotherapy,Mradiation,Msurgery).



TheMnurseMpractitionerMisMcompletingMaMhealthMassessmentMonMaM15-year-
oldMfemaleMpatientMwhoMisMinMtheMofficeMforMherMannualMphysical.MTheMpatientMrepo
rtsMfeelingsMofMhopelessnessMandMsadnessMforMseveralMmonths,MnoMhistoryMofMsuicidal
Mideations,MandMaMstruggleMwithManorexia.MTheMpatientMscoresManM11MonMBeck'sMDe
pressionMInventory.MWhichMantidepressantMwillMtheMnurseMpractitionerMprescribe?

,a.MSertralineM(Zoloft)

b.MLithiumMcarbonateM(Eskalith)

c.MBupropionM(Wellbutrin)

d.MEscitalopramM(Lexapro)M-MAnswerMd.MEscitalopramM[Lexapro]



EscitalopramMisMaMsafeMantidepressantMforManMadolescentMwhoMhasMsevereMdepression
MandMnoMhistoryMofMsuicidalMideations.MSertralineMisMnotMaMsafeMoptionMforMpatients
MyoungerMthanM24MyearsMofMageMbecauseMofMincreasedMriskMofMsuicidalMideation.MBu
propionMisManMatypicalMantidepressantMandMisMnotMaMfirst-
lineMtherapyMforMdepression.MItMisMcontraindicatedMinMpatientsMwithManorexiaMnervosa.
MLithiumMisMindicatedMforMpatientsMwithMbipolarMdisorder.



WhichMinitialMtreatmentMwillMtheMnurseMpractitionerMprescribeMtoMaM23-year-
oldMfemaleMallergicMtoMsulfaMdrugsMwhoMisMdiagnosedMwithMacuteMcystitis?



a.MCephalexinM(Keflex)M500MmgMBIDM×M5Mdays

b.MCiprofloxacinM(Cipro)M250MmgMBIDM×M3Mdays

c.MNitrofurantoinM(Macrobid)M100MmgMBIDM×M5Mdays

d.MAmoxicillinM500MmgMBIDM×M5MdaysM-
MAnswerMc.MNitrofurantoinM(Macrobid)M100MmgMBIDM×M5Mdays



NitrofurantoinMcanMbeMsafelyMadministeredMtoMaMpatientMwithMaMsulfaMallergyMtoMtrea
tMacuteMcystitisMandMisMtheMfirstMlineMofMtreatment.MCephalexinMandMamoxicillinMareM
beta-
lactamMantibioticsMthatMcanMbeMprescribedMforMaMpatientMwhoMhasManMallergyMtoMsul
faMandMnitrofurantoin.MAMfluoroquinolone,MsuchMasMciprofloxacin,MisMrecommendedMfor
MaMpatientMwhoMisMallergicMtoMsulfaMandMbeta-
lactamMdrugsMorMhasMaMsulfaMallergyMandMaMknownMresistanceMtoMbeta-
lactamMantibiotics.



AM68-year-oldMpatientMrecentlyMprescribedMcaridopa-
levodopaM(Sinemet)MtellsMtheMnurseMpractitionerMthatMheMhasMbeenMbloatedMandMexpe
riencingMdifficultyMwithMbowelMmovements.MWhichMmedicationMwillMtheMnurseMpractition
erMconsiderMincorporatingMintoMtheMtreatmentMplan?



a.MSenna

, b.MMethylnaltrexone

c.MMagnesiumMcitrate

d.MPolyethyleneMglycolM-MAnswerMd.MPolyethyleneMglycol



Levodopa,ManMantiparkinsonianMdrug,McanMcauseMconstipationMinManMolderMpatient.MThe
Mfirst-
lineMtreatmentMforMtheMpatient'sMconstipationMisMosmoticMlaxativesMsuchMasMpolyethyle
neMglycol.MSennaMisMaMstimulantMlaxativeMthatMisMaMsecond-
lineMtreatmentMforMconstipationMinManMolderMadult.MMethylnaltrexoneMisMaMperipherally
MactingMmu-
opioidMantagonistMthatMactsMonMtheMgastrointestinalMtractMtoMdecreaseMopioid-
inducedMconstipation.MMagnesium-
basedMlaxativesM(e.g.,MmagnesiumMcitrate)MtakenMoverMtheMlongMtermMshouldMbeMavoi
dedMbecauseMofMtheMpotentialMofMtoxicity.



AMpatientMrecentlyMreturnedMfromMaMtripMtoMAfricaMandMisMexperiencingM10MtoM12Ml
ooseMstoolsMeveryMday.MTheMpatientMtakesMmetforminMeveryMmorningMandMotherwiseMi
sMinMgoodMhealth.MWhichMmedicationMwillMtheMnurseMpractitionerMprescribeMtoMtreatM
theMdiarrhea?



a.MLevofloxacinMdaily

b.MOfloxacinMBID

c.MTrimethoprim-sulfamethoxazoleMBID

d.MCiprofloxacinMinMaMsingleMdoseM-MAnswerMd.MCiprofloxacinMinMaMsingleMdose



TheMpatientMmostMlikelyMhasMtraveler'sMdiarrhea,MgivenMtheMhistoryMofMaMrecentMretur
nMfromManotherMcountry.MTheMpatient'sMtreatmentMshouldMbeMbasedMonMfunctionalMim
pactMofMsymptomsMandMnotMfrequencyMofMsymptoms,MwhichMisMnotMindicatedMinMthe
Mquestion.MTheMpatientMlikelyMhasMmoderateMacuteMtraveler'sMdiarrhea,MwhichMcanMbe
MtreatedMwithMloperamideMasMmonotherapyMorMwithMadjunctiveMantibioticMtherapy.MThe
MpatientMisMtakingMmetforminMdailyMforMdiabetes,MsoMriskMofMprecipitatingMhypoglycemi
aMisMlowerMthanMwithMotherMoralMantidiabeticMagents.MBecauseMitMcanMbeMgivenMinM
aMsingleMdose,MciprofloxacinMwouldMbeMtheMappropriateMchoiceMforMreducingMexposure
MandMmicrobiomeMcolonizationMdisruption.MLevofloxacinMandMofloxacinMrequireMoneMtoM
threeMdoses.MTrimethoprim-
sulfamethoxazoleMisMaMsulfonamideMandMwouldMbeMappropriateMtreatmentMforMcyclospor
iasisMbutMnotMgiardiasis,MwhichMisMtheMmostMcommonMparasiticMcauseMofMtraveler'sMdi
arrhea.