ESTUDYR
RN HESI PHARMACOLOGY V2 (2026) |
ACTUAL EXAMS WITH RATIONALES
1. When administering chelation therapy for a toddler with lead poisoning, which nursing
action is the priority?
A. Assessing vital signs
B. Monitoring urine output
C. Conducting a behavioral assessment
D. Providing education to reduce lead exposure
✅Correct Answer: B — Monitoring urine output
Rationale:
Chelation therapy binds heavy metals (such as lead) so they can be excreted in urine.
Monitoring urinary output is essential to ensure effective elimination and detect renal toxicity
or impaired excretion.
2. A 67-year-old client with influenza A also has asthma. Which antiviral medication should
the nurse recommend avoiding?
A. Ribavirin
B. Zanamivir
C. Oseltamivir
D. Amantadine
✅Correct Answer: B — Zanamivir
Rationale:
Zanamivir is an inhaled antiviral that may cause bronchospasm, making it contraindicated in
patients with asthma or COPD.
3. Which first-line medication is used to treat anaphylactic reactions?
A. Epinephrine
B. Norepinephrine
,ESTUDYR
C. Dexamethasone
D. Diphenhydramine
✅Correct Answer: A — Epinephrine
Rationale:
Epinephrine is the first-line emergency treatment because it:
Causes bronchodilation
Increases blood pressure
Reduces airway edema
4. Prolonged use of which medication can cause yellow discoloration of a child's teeth?
A. Tetracycline
B. Promethazine
C. Chloramphenicol
D. Fluoroquinolones
✅Correct Answer: A — Tetracycline
Rationale:
Tetracycline binds to calcium in developing teeth, causing:
Permanent yellow-brown discoloration
Enamel hypoplasia
Therefore, it is contraindicated in children under 8 years and pregnancy.
5. What are desired outcomes when administering an NSAID? (Select all that apply)
A. Diuresis
B. Pain relief
C. Antipyresis
D. Bronchodilation
E. Anticoagulation
F. Reduced inflammation
, ESTUDYR
✅Correct Answers: B, C, F
Rationale:
NSAIDs provide:
Analgesic effects (pain relief)
Antipyretic effects (fever reduction)
Anti-inflammatory effects
They do not cause bronchodilation or anticoagulation.
6. Which statement indicates that teaching about rifampin is effective?
A. "I need to drink large amounts of fluids."
B. "My urine may turn orange."
C. "My hearing must be monitored."
D. "Skin rash is expected."
✅Correct Answer: B
Rationale:
Rifampin commonly causes orange-red discoloration of urine, tears, and sweat. This is
harmless but important for patients to know.
7. Which statement indicates correct understanding of interferon therapy?
A. "I will drink 2–3 liters of fluid daily."
B. "Reconstituted solution lasts 1 week."
C. "Driving is safe during therapy."
D. "Normal activity should not change."
✅Correct Answer: A
Rationale:
Interferon therapy can cause flu-like symptoms and dehydration; therefore adequate fluid
intake is recommended.
RN HESI PHARMACOLOGY V2 (2026) |
ACTUAL EXAMS WITH RATIONALES
1. When administering chelation therapy for a toddler with lead poisoning, which nursing
action is the priority?
A. Assessing vital signs
B. Monitoring urine output
C. Conducting a behavioral assessment
D. Providing education to reduce lead exposure
✅Correct Answer: B — Monitoring urine output
Rationale:
Chelation therapy binds heavy metals (such as lead) so they can be excreted in urine.
Monitoring urinary output is essential to ensure effective elimination and detect renal toxicity
or impaired excretion.
2. A 67-year-old client with influenza A also has asthma. Which antiviral medication should
the nurse recommend avoiding?
A. Ribavirin
B. Zanamivir
C. Oseltamivir
D. Amantadine
✅Correct Answer: B — Zanamivir
Rationale:
Zanamivir is an inhaled antiviral that may cause bronchospasm, making it contraindicated in
patients with asthma or COPD.
3. Which first-line medication is used to treat anaphylactic reactions?
A. Epinephrine
B. Norepinephrine
,ESTUDYR
C. Dexamethasone
D. Diphenhydramine
✅Correct Answer: A — Epinephrine
Rationale:
Epinephrine is the first-line emergency treatment because it:
Causes bronchodilation
Increases blood pressure
Reduces airway edema
4. Prolonged use of which medication can cause yellow discoloration of a child's teeth?
A. Tetracycline
B. Promethazine
C. Chloramphenicol
D. Fluoroquinolones
✅Correct Answer: A — Tetracycline
Rationale:
Tetracycline binds to calcium in developing teeth, causing:
Permanent yellow-brown discoloration
Enamel hypoplasia
Therefore, it is contraindicated in children under 8 years and pregnancy.
5. What are desired outcomes when administering an NSAID? (Select all that apply)
A. Diuresis
B. Pain relief
C. Antipyresis
D. Bronchodilation
E. Anticoagulation
F. Reduced inflammation
, ESTUDYR
✅Correct Answers: B, C, F
Rationale:
NSAIDs provide:
Analgesic effects (pain relief)
Antipyretic effects (fever reduction)
Anti-inflammatory effects
They do not cause bronchodilation or anticoagulation.
6. Which statement indicates that teaching about rifampin is effective?
A. "I need to drink large amounts of fluids."
B. "My urine may turn orange."
C. "My hearing must be monitored."
D. "Skin rash is expected."
✅Correct Answer: B
Rationale:
Rifampin commonly causes orange-red discoloration of urine, tears, and sweat. This is
harmless but important for patients to know.
7. Which statement indicates correct understanding of interferon therapy?
A. "I will drink 2–3 liters of fluid daily."
B. "Reconstituted solution lasts 1 week."
C. "Driving is safe during therapy."
D. "Normal activity should not change."
✅Correct Answer: A
Rationale:
Interferon therapy can cause flu-like symptoms and dehydration; therefore adequate fluid
intake is recommended.
