Placement of drug under the tongue.
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Sublingual ROA
Ease of administration, rapid absorption, bypass of the harsh gastrointestinal (GI)
environment, and avoidance of first-pass metabolism (see discussion of first-pass
metabolism below)
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Advantages of Sublingual/Buccal ROA
, Useful for acid labile and drugs that are irritating to the stomach (i.e. aspirin).
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Advantage of Enteric-coated Preparations
The drug may be biotransformed through metabolism by the liver or other tissues.
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Metabolism
Pathways involved are the most complicated, and the low gastric pH inactivates some
drugs.
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Disadvantage of Oral ROA
Can be dosed less frequently and may improve patient compliance.
May maintain concentrations within the therapeutic range over a longer duration.
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Advantage of Extended-release Preparations
Give this one a try later!
Sublingual ROA
Ease of administration, rapid absorption, bypass of the harsh gastrointestinal (GI)
environment, and avoidance of first-pass metabolism (see discussion of first-pass
metabolism below)
Give this one a try later!
Advantages of Sublingual/Buccal ROA
, Useful for acid labile and drugs that are irritating to the stomach (i.e. aspirin).
Give this one a try later!
Advantage of Enteric-coated Preparations
The drug may be biotransformed through metabolism by the liver or other tissues.
Give this one a try later!
Metabolism
Pathways involved are the most complicated, and the low gastric pH inactivates some
drugs.
Give this one a try later!
Disadvantage of Oral ROA
Can be dosed less frequently and may improve patient compliance.
May maintain concentrations within the therapeutic range over a longer duration.
Give this one a try later!
Advantage of Extended-release Preparations
