NBME CBSE FINAL EXAM QUESTIONS
2025/2026 WITH CORRECT DETAILED
ANSWERS || ALREADY GRADED A+
<RECENT VERSION>
What is the expected beneficial effect of bisphosphonates in osteoporosis? -
ANSWER Decreased osteoclast activity
What is the relative risk ratio for hip fractures among elderly women who exercise
regularly? - ANSWER 1.2 (95% confidence interval of 1.1 to 1.8)
What is the most immediate treatment mechanism of action for chest pain
radiating to the jaw? - ANSWER Increased nitric oxide concentration
What causes the formation of tissue in a wound from hot grease? -
ANSWER Increased activity of Vascular Endothelial Growth Factor (VEGF),
which stimulates angiogenesis
,What is the effect of desmopressin on urine osmolarity? - ANSWER Increases
urine osmolarity due to activation of adenylyl cyclase
What is the likely infectious agent in a child with fever, cough, and wheezing who
attends daycare? - ANSWER An agent that mediates cell entry via a fusion
protein
What pharmacotherapy is most appropriate for a patient with mild wheezing after
a bee sting? - ANSWER B2-agonist
What is the diagnosis for a 14-year-old boy with a sore throat, fever, and cervical
lymphadenopathy? - ANSWER Infectious Mononucleosis
What phase of the cell cycle is defective in a tumor that continues to grow despite
radiation therapy? - ANSWER G1 phase
What is the diagnosis for a patient with bilateral hydroureter and hydronephrosis,
who lived in sub-Saharan Africa? - ANSWER Schistosomiasis
What is the expected percentage of offspring with a two-gene deletion from a
couple with a-thalassemia? - ANSWER 50%
What is the diagnosis for a previously healthy 40-year-old woman with fever,
lethargy, and low platelets? - ANSWER Thrombotic Thrombocytopenic Purpura
, What is the diagnosis for a 16-year-old boy with a knife wound to the chest
showing air-fluid levels? - ANSWER Hemopneumothorax
What are the effects of atorvastatin and losartan on HDL and triglycerides? -
ANSWER HDL increased, triglycerides decreased
What vitamin deficiency is indicated by diffuse weakness and decreased sensation
in a 73-year-old woman? - ANSWER Vitamin B12 deficiency (cyanocobalamin)
What is the underlying cause of acne in a 15-year-old girl? -
ANSWER Stimulation of sebaceous glands by androgens
What process is indicated by a biopsy of a lesion in the jaw that resembles
Burkitt's lymphoma? - ANSWER Apoptosis
What lymph nodes should be evaluated first for metastasis in a patient with a
tongue mass? - ANSWER Submental lymph nodes
What pathogen is indicated by cysts and trophozoites found in a lumbar puncture
of a patient with confusion and agitation? - ANSWER Naegleria fowleri
What drug is likely ingested by a patient showing hostility and rigidity after being
found with a blank stare? - ANSWER PCP (Phencyclidine)
What is the likely result of a clinical trial with alpha set at 0.01 instead of 0.05? -
ANSWER Significant findings can be reported with greater confidence
, What is the cause of amenorrhea in a 17-year-old gymnast with a BMI of 15? -
ANSWER Low body weight leading to hormonal imbalance
What is hypogonadotropic hypogonadism? - ANSWER A condition
characterized by low levels of sex hormones due to insufficient stimulation from
the pituitary gland.
What is oligohydramnios? - ANSWER A condition marked by a deficiency of
amniotic fluid, which can lead to complications during pregnancy.
What is pulmonary hypoplasia? - ANSWER Underdevelopment of the lungs,
often associated with oligohydramnios.
What is the likely metabolic finding in a newborn with jaundice and
hepatomegaly? - ANSWER Increased concentration of galactose-1-phosphate
due to congenital intolerance to breast milk.
What is the most effective antibiotic for a patient with severe muscle pain and
necrotic material? - ANSWER An antibiotic that interferes with ribosomal
assembly, such as those used against Yersinia pestis.
What additional findings are expected in a patient with amyotrophic lateral
sclerosis (ALS)? - ANSWER Atrophy and weakness of muscles, particularly in
the upper and lower extremities.
2025/2026 WITH CORRECT DETAILED
ANSWERS || ALREADY GRADED A+
<RECENT VERSION>
What is the expected beneficial effect of bisphosphonates in osteoporosis? -
ANSWER Decreased osteoclast activity
What is the relative risk ratio for hip fractures among elderly women who exercise
regularly? - ANSWER 1.2 (95% confidence interval of 1.1 to 1.8)
What is the most immediate treatment mechanism of action for chest pain
radiating to the jaw? - ANSWER Increased nitric oxide concentration
What causes the formation of tissue in a wound from hot grease? -
ANSWER Increased activity of Vascular Endothelial Growth Factor (VEGF),
which stimulates angiogenesis
,What is the effect of desmopressin on urine osmolarity? - ANSWER Increases
urine osmolarity due to activation of adenylyl cyclase
What is the likely infectious agent in a child with fever, cough, and wheezing who
attends daycare? - ANSWER An agent that mediates cell entry via a fusion
protein
What pharmacotherapy is most appropriate for a patient with mild wheezing after
a bee sting? - ANSWER B2-agonist
What is the diagnosis for a 14-year-old boy with a sore throat, fever, and cervical
lymphadenopathy? - ANSWER Infectious Mononucleosis
What phase of the cell cycle is defective in a tumor that continues to grow despite
radiation therapy? - ANSWER G1 phase
What is the diagnosis for a patient with bilateral hydroureter and hydronephrosis,
who lived in sub-Saharan Africa? - ANSWER Schistosomiasis
What is the expected percentage of offspring with a two-gene deletion from a
couple with a-thalassemia? - ANSWER 50%
What is the diagnosis for a previously healthy 40-year-old woman with fever,
lethargy, and low platelets? - ANSWER Thrombotic Thrombocytopenic Purpura
, What is the diagnosis for a 16-year-old boy with a knife wound to the chest
showing air-fluid levels? - ANSWER Hemopneumothorax
What are the effects of atorvastatin and losartan on HDL and triglycerides? -
ANSWER HDL increased, triglycerides decreased
What vitamin deficiency is indicated by diffuse weakness and decreased sensation
in a 73-year-old woman? - ANSWER Vitamin B12 deficiency (cyanocobalamin)
What is the underlying cause of acne in a 15-year-old girl? -
ANSWER Stimulation of sebaceous glands by androgens
What process is indicated by a biopsy of a lesion in the jaw that resembles
Burkitt's lymphoma? - ANSWER Apoptosis
What lymph nodes should be evaluated first for metastasis in a patient with a
tongue mass? - ANSWER Submental lymph nodes
What pathogen is indicated by cysts and trophozoites found in a lumbar puncture
of a patient with confusion and agitation? - ANSWER Naegleria fowleri
What drug is likely ingested by a patient showing hostility and rigidity after being
found with a blank stare? - ANSWER PCP (Phencyclidine)
What is the likely result of a clinical trial with alpha set at 0.01 instead of 0.05? -
ANSWER Significant findings can be reported with greater confidence
, What is the cause of amenorrhea in a 17-year-old gymnast with a BMI of 15? -
ANSWER Low body weight leading to hormonal imbalance
What is hypogonadotropic hypogonadism? - ANSWER A condition
characterized by low levels of sex hormones due to insufficient stimulation from
the pituitary gland.
What is oligohydramnios? - ANSWER A condition marked by a deficiency of
amniotic fluid, which can lead to complications during pregnancy.
What is pulmonary hypoplasia? - ANSWER Underdevelopment of the lungs,
often associated with oligohydramnios.
What is the likely metabolic finding in a newborn with jaundice and
hepatomegaly? - ANSWER Increased concentration of galactose-1-phosphate
due to congenital intolerance to breast milk.
What is the most effective antibiotic for a patient with severe muscle pain and
necrotic material? - ANSWER An antibiotic that interferes with ribosomal
assembly, such as those used against Yersinia pestis.
What additional findings are expected in a patient with amyotrophic lateral
sclerosis (ALS)? - ANSWER Atrophy and weakness of muscles, particularly in
the upper and lower extremities.
