2026 High-Yield Clinical Flashcards for
COMSAE 115
DESCRIPTION
COMSAE Phase 1 (Form 115) is a 176-question diagnostic exam used by osteopathic
medical students to predict readiness for the COMLEX-USA Level 1 boards.
Quick Stats
• Format: 4 sections of 44 questions (176 total).
• Time: 4 hours (~72 seconds per question).
• Passing Score: Typically 400, though many schools require 450+ to sit for
boards.
• Key Feature: The "b" version (e.g., 115b) now includes an answer key for
student-purchased forms [1].
High-Yield Content
• OMM (Heavy): Focuses on Sacral Torsions, Cranial Strains, and Chapman
Points.
• Systems: Strong emphasis on Neuro (stroke/cranial nerves)
and Cardio (murmurs/ECG).
• Ethics: High frequency of questions regarding autonomy and informed
consent.
Strategic Use
It is best used as a "mid-point" or "final" check during dedicated study to simulate board-
style pacing and identify weak body systems.
2026 Question And ANSWER Latest Update
, QUESTION :G6PD deficiency - CORRECT ANSWER Identified by bite cells and Heinz
bodies on blood smear, hemolytic anemia after fava bean ingestion.
QUESTION :Thyroid storm - CORRECT ANSWER Occurs in a patient with
hyperthyroidism who develops fever, tachycardia, confusion, and vomiting after surgery.
QUESTION :Neural tube defect - CORRECT ANSWER Main concern with elevated
AFP in a pregnant woman's amniotic fluid (e.g., spina bifida).
QUESTION :Hereditary spherocytosis - CORRECT ANSWER Diagnosed with
spherocytes, increased osmotic fragility, and negative Coombs test.
QUESTION :Ankylosing spondylitis - CORRECT ANSWER Associated with HLA-B27
positivity, low back pain, and uveitis.
QUESTION :Ulnar nerve - CORRECT ANSWER Affected in a patient with 'claw hand'
deformity and loss of sensation in the medial hand.
QUESTION :Left middle cerebral artery stroke - CORRECT ANSWER Causes sudden
onset unilateral weakness, face droop, and expressive aphasia affecting Broca's area.
QUESTION :Pyruvate kinase deficiency - CORRECT ANSWER Leads to impaired
glycolysis and nonspherocytic hemolytic anemia.
QUESTION :Granulosa cell tumor - CORRECT ANSWER Identified by 'soap bubble'
appearance on ovarian tumor histology.
2026 Question And ANSWER Latest Update
COMSAE 115
DESCRIPTION
COMSAE Phase 1 (Form 115) is a 176-question diagnostic exam used by osteopathic
medical students to predict readiness for the COMLEX-USA Level 1 boards.
Quick Stats
• Format: 4 sections of 44 questions (176 total).
• Time: 4 hours (~72 seconds per question).
• Passing Score: Typically 400, though many schools require 450+ to sit for
boards.
• Key Feature: The "b" version (e.g., 115b) now includes an answer key for
student-purchased forms [1].
High-Yield Content
• OMM (Heavy): Focuses on Sacral Torsions, Cranial Strains, and Chapman
Points.
• Systems: Strong emphasis on Neuro (stroke/cranial nerves)
and Cardio (murmurs/ECG).
• Ethics: High frequency of questions regarding autonomy and informed
consent.
Strategic Use
It is best used as a "mid-point" or "final" check during dedicated study to simulate board-
style pacing and identify weak body systems.
2026 Question And ANSWER Latest Update
, QUESTION :G6PD deficiency - CORRECT ANSWER Identified by bite cells and Heinz
bodies on blood smear, hemolytic anemia after fava bean ingestion.
QUESTION :Thyroid storm - CORRECT ANSWER Occurs in a patient with
hyperthyroidism who develops fever, tachycardia, confusion, and vomiting after surgery.
QUESTION :Neural tube defect - CORRECT ANSWER Main concern with elevated
AFP in a pregnant woman's amniotic fluid (e.g., spina bifida).
QUESTION :Hereditary spherocytosis - CORRECT ANSWER Diagnosed with
spherocytes, increased osmotic fragility, and negative Coombs test.
QUESTION :Ankylosing spondylitis - CORRECT ANSWER Associated with HLA-B27
positivity, low back pain, and uveitis.
QUESTION :Ulnar nerve - CORRECT ANSWER Affected in a patient with 'claw hand'
deformity and loss of sensation in the medial hand.
QUESTION :Left middle cerebral artery stroke - CORRECT ANSWER Causes sudden
onset unilateral weakness, face droop, and expressive aphasia affecting Broca's area.
QUESTION :Pyruvate kinase deficiency - CORRECT ANSWER Leads to impaired
glycolysis and nonspherocytic hemolytic anemia.
QUESTION :Granulosa cell tumor - CORRECT ANSWER Identified by 'soap bubble'
appearance on ovarian tumor histology.
2026 Question And ANSWER Latest Update
