NU664C MIDTERM EXAM STUDY GUIDE
2025/2026 ACCURATE QUESTIONS WITH
CORRECT DETAILED ANSWERS || 100%
GUARANTEED PASS RECENT VERSION
Description (100 Words):
This study guide is designed for students preparing for the NU664C Midterm Exam, covering
advanced clinical nursing concepts, patient assessment, and pharmacologic management
across multiple body systems. Topics include cardiovascular, respiratory, neurological,
gastrointestinal, endocrine, renal, and musculoskeletal disorders, with emphasis on
pathophysiology, diagnostic interpretation, evidence-based interventions, and treatment
planning. The guide provides accurate, exam-style questions with detailed explanations to
reinforce critical thinking, clinical reasoning, and application of knowledge to real-world
patient care scenarios. Case-based exercises and practical examples strengthen decision-
making and problem-solving skills, ensuring students are confident, fully prepared, and
capable of excelling on the NU664C Midterm Exam.
Key Terms:
NU664C, Midterm Exam, Clinical Assessment, Pharmacology, Multisystem Disorders,
Pathophysiology, Diagnostic Evaluation, Evidence-Based Practice, Patient Management, Case
Studies, Clinical Reasoning, Treatment Planning
Know the route of administration for newer agent asenapine (Saphris) and what instructions
should be given to the patient regarding administration. ------- ✔ CORRECT ANSWER ✓✓Route-
Sublingual
Not to eat or drink for 10 minutes after medication administration
Not to swallow or chew the capsule.
Asenapine is an atypical antipsychotic (serotonin-dopamine antagonist, as a mood stabilizer).
Asenapine is not absorbed after swallowing (less than 2% bioavailable orally) and thus must be
administered sublingually (35% bioavailable), as swallowing would render asenapine inactive.
,Patients should be instructed to place the tablet under the tongue and allow it to dissolve
completely, which will occur in seconds; tablet should not be divided, crushed, chewed, or
swallowed.
Patients may not eat or drink for 10 minutes following sublingual administration so that the
drug in the oral cavity can be absorbed locally and not washed into the stomach (where it would
not be absorbed).
Due to rapid onset of action, can be used as a rapid acting "prn" or "as needed" dose for
agitation or transient worsening of psychosis or mania instead of an injection.
Treatment should be suspended if absolute neutrophil count falls below 1,000/mm3.
Know and describe the top atypical antipsychotic with greatest incidence of prolonged QTc
interval. ------- ✔ CORRECT ANSWER ✓✓Ziprasidone (Geodon).
Normal QTc =450.
>470, Call Cardiologist
>500, stop all meds.
Ziprasidone (Geodon) has been associated with a dose-related prolongation of the QTc
QTc interval prolongation is greatest with ziprasidone and least with olanzapine.
Ziprasidone (Geodon) an atypical antipsychotic (serotonin-dopamine antagonist; second-
generation antipsychotic; also a mood stabilizer.
Ziprasidone is prescribed for Schizophrenia, delaying relapse in schizophrenia, acute agitation in
schizophrenia (intramuscular), acute mania/mixed mania, bipolar maintenance, other psychotic
d/o, bipolar depression, behavioral disturbances in dementias, behavioral disturbances in
children and adolescents, and disorders associated with problems with impulse control.
Ziprasidone blocks dopamine 2 receptors, reducing positive symptoms of psychosis and
stabilizing affective symptoms. Blocks serotonin 2A receptors, causing enhancement of
dopamine release in certain brain regions and thus reducing motor side effects and possible
improving cognitive and affective symptoms.
EKGs may be useful for selected patients (e.g., those with personal or family history of QTc
prolongation; cardiac arrhythmia; recent myocardial infarction; uncompensated heart failure; or
those taking agents that prolong QTc interval (such as pimozide, thioridazine, selected
antiarrhythmics, moxifloxacin, sparfloxacin, etc.)
, Ziprasidone prolongs QTc interval more than some other antipsychotics.
Ziprasidone is associated with rare but serious skin condition known as Drug Reaction with
Eosinophilia (DRESS). DRESS may begin as a rash but can progress to other parts of the body and
can include symptoms such as fever, swollen lymph nodes, swollen face, inflammation of
organs, and an increase in white blood cells known as eosinophilia. In some cases, DRESS can
lead to death. Clinic
Know which antipsychotics have specific instructions for minimum food intake or diet
restrictions. ------- ✔ CORRECT ANSWER ✓✓Geodon because food affects the absorption of the
drug.
Lurasidone - Latuda
Know an alternative atypical antipsychotic for a patient who has developed diabetes and has a
significant weight gain from treatment with olanzapine. ------- ✔ CORRECT ANSWER ✓✓Abilify
or Geodon, or Lurasidone (Latuda)
Because they are weight neutral or causes minimal weight gain.
Know whether a patient is demonstrating efficacy to clozapine 500 mg/day if this week's
granulocyte count is less than 500mm3. What is the most appropriate recommendation for drug
therapy? ------- ✔ CORRECT ANSWER ✓✓Stop the drug, because of the risk of agranulocytosis
and patient can be infected.
The most appropriate recommendation for drug therapy is to repeat CBC weekly.
> 1500, watch carefully if is at 1000
Know the common effects of smoking along with antipsychotic drug therapy such as
olanzapine. ------- ✔ CORRECT ANSWER ✓✓Smoking reduces the level of Olanzapine because of
its metabolism at CYP450 enzyme.
2025/2026 ACCURATE QUESTIONS WITH
CORRECT DETAILED ANSWERS || 100%
GUARANTEED PASS RECENT VERSION
Description (100 Words):
This study guide is designed for students preparing for the NU664C Midterm Exam, covering
advanced clinical nursing concepts, patient assessment, and pharmacologic management
across multiple body systems. Topics include cardiovascular, respiratory, neurological,
gastrointestinal, endocrine, renal, and musculoskeletal disorders, with emphasis on
pathophysiology, diagnostic interpretation, evidence-based interventions, and treatment
planning. The guide provides accurate, exam-style questions with detailed explanations to
reinforce critical thinking, clinical reasoning, and application of knowledge to real-world
patient care scenarios. Case-based exercises and practical examples strengthen decision-
making and problem-solving skills, ensuring students are confident, fully prepared, and
capable of excelling on the NU664C Midterm Exam.
Key Terms:
NU664C, Midterm Exam, Clinical Assessment, Pharmacology, Multisystem Disorders,
Pathophysiology, Diagnostic Evaluation, Evidence-Based Practice, Patient Management, Case
Studies, Clinical Reasoning, Treatment Planning
Know the route of administration for newer agent asenapine (Saphris) and what instructions
should be given to the patient regarding administration. ------- ✔ CORRECT ANSWER ✓✓Route-
Sublingual
Not to eat or drink for 10 minutes after medication administration
Not to swallow or chew the capsule.
Asenapine is an atypical antipsychotic (serotonin-dopamine antagonist, as a mood stabilizer).
Asenapine is not absorbed after swallowing (less than 2% bioavailable orally) and thus must be
administered sublingually (35% bioavailable), as swallowing would render asenapine inactive.
,Patients should be instructed to place the tablet under the tongue and allow it to dissolve
completely, which will occur in seconds; tablet should not be divided, crushed, chewed, or
swallowed.
Patients may not eat or drink for 10 minutes following sublingual administration so that the
drug in the oral cavity can be absorbed locally and not washed into the stomach (where it would
not be absorbed).
Due to rapid onset of action, can be used as a rapid acting "prn" or "as needed" dose for
agitation or transient worsening of psychosis or mania instead of an injection.
Treatment should be suspended if absolute neutrophil count falls below 1,000/mm3.
Know and describe the top atypical antipsychotic with greatest incidence of prolonged QTc
interval. ------- ✔ CORRECT ANSWER ✓✓Ziprasidone (Geodon).
Normal QTc =450.
>470, Call Cardiologist
>500, stop all meds.
Ziprasidone (Geodon) has been associated with a dose-related prolongation of the QTc
QTc interval prolongation is greatest with ziprasidone and least with olanzapine.
Ziprasidone (Geodon) an atypical antipsychotic (serotonin-dopamine antagonist; second-
generation antipsychotic; also a mood stabilizer.
Ziprasidone is prescribed for Schizophrenia, delaying relapse in schizophrenia, acute agitation in
schizophrenia (intramuscular), acute mania/mixed mania, bipolar maintenance, other psychotic
d/o, bipolar depression, behavioral disturbances in dementias, behavioral disturbances in
children and adolescents, and disorders associated with problems with impulse control.
Ziprasidone blocks dopamine 2 receptors, reducing positive symptoms of psychosis and
stabilizing affective symptoms. Blocks serotonin 2A receptors, causing enhancement of
dopamine release in certain brain regions and thus reducing motor side effects and possible
improving cognitive and affective symptoms.
EKGs may be useful for selected patients (e.g., those with personal or family history of QTc
prolongation; cardiac arrhythmia; recent myocardial infarction; uncompensated heart failure; or
those taking agents that prolong QTc interval (such as pimozide, thioridazine, selected
antiarrhythmics, moxifloxacin, sparfloxacin, etc.)
, Ziprasidone prolongs QTc interval more than some other antipsychotics.
Ziprasidone is associated with rare but serious skin condition known as Drug Reaction with
Eosinophilia (DRESS). DRESS may begin as a rash but can progress to other parts of the body and
can include symptoms such as fever, swollen lymph nodes, swollen face, inflammation of
organs, and an increase in white blood cells known as eosinophilia. In some cases, DRESS can
lead to death. Clinic
Know which antipsychotics have specific instructions for minimum food intake or diet
restrictions. ------- ✔ CORRECT ANSWER ✓✓Geodon because food affects the absorption of the
drug.
Lurasidone - Latuda
Know an alternative atypical antipsychotic for a patient who has developed diabetes and has a
significant weight gain from treatment with olanzapine. ------- ✔ CORRECT ANSWER ✓✓Abilify
or Geodon, or Lurasidone (Latuda)
Because they are weight neutral or causes minimal weight gain.
Know whether a patient is demonstrating efficacy to clozapine 500 mg/day if this week's
granulocyte count is less than 500mm3. What is the most appropriate recommendation for drug
therapy? ------- ✔ CORRECT ANSWER ✓✓Stop the drug, because of the risk of agranulocytosis
and patient can be infected.
The most appropriate recommendation for drug therapy is to repeat CBC weekly.
> 1500, watch carefully if is at 1000
Know the common effects of smoking along with antipsychotic drug therapy such as
olanzapine. ------- ✔ CORRECT ANSWER ✓✓Smoking reduces the level of Olanzapine because of
its metabolism at CYP450 enzyme.
