UTMB 5355 EXAM 2 ADVANCED
PATHOPHYSIOLOGY BASIC PRACTICE
TEST 2026 TESTED QUESTIONS WITH
COMPLETE ANSWERS GRADED A+
⩥ Proto-oncogenes. Answer: promote normal cell growth factor and
division
⩥ If proto-oncogenes are mutated the become -. Answer: Oncogenes
⩥ Tumor Supressor Genes (TSGs) are. Answer: Antioncogenes
⩥ antioncogenes. Answer: inhibit tumor progression & prevent
mutations
⩥ Cancer develops with increase in - and decrease in -. Answer:
oncogenes, tumor suppressor genes
⩥ What are the 2 main types of Tumor Suppressor Genes?. Answer:
Gatekeepers & Caretakers
⩥ tumor suppressor genes. Answer: encode proteins that inhibit growth,
prevent and repair mutations but if mutated will increase cancer risk
,⩥ Gatekeeper. Answer: regulate cell proliferation, cell type specific,
normally prevent uncontrolled growth and potential progression of
cancer
⩥ Caretaker. Answer: suppress gene mutations, repair DNA, if not
functioning correctly mutation can occur
⩥ How does chronic inflammation cause cancer?. Answer: Inflammation
increases free radicals and reactive oxygen species which promote
mutation
⩥ interfere with insulin signaling leading to insulin resistance in stress,
obesity, and Type 2 Diabetes.. Answer: Pro-inflammatory cytokines
⩥ TP53 gene. Answer: tumor suppressor gene, if lost due to mutation
cells escape apoptosis and can divide indefinitely increasing risk of
cancer
⩥ tumor necrosis factor is _ cytokine. Answer: pro-inflammatory, may
be related to carcinogenesis
⩥ 4 functions of TNF. Answer: 1)cell survival
2)cell proliferation
, 3) cell differentiation
4)cell death
⩥ CA therapy in relation to TNF. Answer: Modulation of TNF/receptors
⩥ tumor markers. Answer: not used to diagnose, but can be useful in
surveillance of cancers or after cancer treatments, elevated in some
cancers
⩥ tumor markers are produced by both. Answer: benign & malignant
cells, increased levels seen in cancerous/noncancerous tumors
⩥ tumor markers include. Answer: hormones, enzymes, genes, antigens
and antibodies
⩥ CA19-9. Answer: pancreatic cancer
⩥ CA-125. Answer: ovarian cancer
⩥ Alpha-fetoprotein (AFP). Answer: hepatic, germ cell CA
⩥ CEA. Answer: colon cancer
PATHOPHYSIOLOGY BASIC PRACTICE
TEST 2026 TESTED QUESTIONS WITH
COMPLETE ANSWERS GRADED A+
⩥ Proto-oncogenes. Answer: promote normal cell growth factor and
division
⩥ If proto-oncogenes are mutated the become -. Answer: Oncogenes
⩥ Tumor Supressor Genes (TSGs) are. Answer: Antioncogenes
⩥ antioncogenes. Answer: inhibit tumor progression & prevent
mutations
⩥ Cancer develops with increase in - and decrease in -. Answer:
oncogenes, tumor suppressor genes
⩥ What are the 2 main types of Tumor Suppressor Genes?. Answer:
Gatekeepers & Caretakers
⩥ tumor suppressor genes. Answer: encode proteins that inhibit growth,
prevent and repair mutations but if mutated will increase cancer risk
,⩥ Gatekeeper. Answer: regulate cell proliferation, cell type specific,
normally prevent uncontrolled growth and potential progression of
cancer
⩥ Caretaker. Answer: suppress gene mutations, repair DNA, if not
functioning correctly mutation can occur
⩥ How does chronic inflammation cause cancer?. Answer: Inflammation
increases free radicals and reactive oxygen species which promote
mutation
⩥ interfere with insulin signaling leading to insulin resistance in stress,
obesity, and Type 2 Diabetes.. Answer: Pro-inflammatory cytokines
⩥ TP53 gene. Answer: tumor suppressor gene, if lost due to mutation
cells escape apoptosis and can divide indefinitely increasing risk of
cancer
⩥ tumor necrosis factor is _ cytokine. Answer: pro-inflammatory, may
be related to carcinogenesis
⩥ 4 functions of TNF. Answer: 1)cell survival
2)cell proliferation
, 3) cell differentiation
4)cell death
⩥ CA therapy in relation to TNF. Answer: Modulation of TNF/receptors
⩥ tumor markers. Answer: not used to diagnose, but can be useful in
surveillance of cancers or after cancer treatments, elevated in some
cancers
⩥ tumor markers are produced by both. Answer: benign & malignant
cells, increased levels seen in cancerous/noncancerous tumors
⩥ tumor markers include. Answer: hormones, enzymes, genes, antigens
and antibodies
⩥ CA19-9. Answer: pancreatic cancer
⩥ CA-125. Answer: ovarian cancer
⩥ Alpha-fetoprotein (AFP). Answer: hepatic, germ cell CA
⩥ CEA. Answer: colon cancer
