ONS Chemotherapy Immunotherapy Certificate with
Complete Solutions
3 major phases of cell division: - -
Interphase
Mitotic phase Define neoadjuvant therapy - -Treatment is
Cytokinesis given prior to surgery to shrink the tumor
3 steps of interphase: - -First growth phase Define adjuvant therapy - -Additional
(G1) cancer treatment given after the primary
Synthesis phase (S phase) treatment to lower the risk that the cancer
Second growth phase (G2) reoccur
4 phases of mitosis: - -Prophase Define conditioning/preparative therapy - -
Metaphase Treatments used to prepare a patient for stem
Anaphase cell transplantation
Telophase
2 types of conditioning therapies: - -
Innate immunity: - -Non-specific response, Myeloablative
either: Nonmyeloablative
1. Barrier (skin, mucous membranes, flora of
skin/gut)
2. Cellular components (phagocytes, natural Define dose density - -Drug dose per unit
killer cells, granulocytes, macrophages) of time
Adaptive immunity: - -Follows innate Define dose intensity - -Amount of drug
immunity if unsuccessful. Memory immunity, delivered over time
including:
1. Humoral immunity (production of antibodies or
immunoglobulins) How is relative dose intensity (RDI) calculated? -
2. Cell mediated immunity (dependent upon T -By comparing the dose that the patient
cells) ACTUALLY received to the planned dose of the
3. Regulatory T -cells (prevent autoimmune standard regimen
reactions and limit inflammatory responses)
How do alkylating agents work? - -By
Define mutations - -Variations in the causing a break in the DNA helix strand,
nucleotide sequence of a gene interfering with DNA replication and causing cell
death
3 main goals of treatment: - -Cure
Control 3 subcategories of alkylating agents: - -1.
Palliation
, ONS Chemotherapy Immunotherapy Certificate with
Complete Solutions
Nitrogen mustards Creatinine
2. Platinum-based agents (do not possess an CBC w/ diff
alkyl group but still termed alkylating agents as
they work similarly)
3. Nitrosoureas What is the medication Mesna used for? - -
Bladder protectant with administration of
cyclophosphamide or ifosfamide
Most common subcategory of alkylating agents: -
-Nitrogen mustards
Instruct pts receiving ________ to avoid
exposure to cold air and consuming cold fluids for
Common alkylating agents: - - 3-4 days following treatment - -Oxaliplatin
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda) How do antimetabolites function? - -By
blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Common platinum-based agents: - -
Cisplatin (Platinol)
Carboplatin (Paraplatin) Antimetabolites work in the ___ phase. - -S
What is unique about nitrosoureas agents? - What types of cells are best affected by
-Able to cross the blood-brain barrier; can antimetabolites? - -Cells with high division
be effective in treating some brain tumors rates
Common nitrosoureas agents: - - Common side effects of antimetabolites: - -
Carmustine (BiCNU) Myelosuppression
Lomustine (CeeNu) GI toxicities
Streptozocin (Zanosar) Photosensitivity
Hand-foot syndrome
Hypersensitivity can occur with late doses of: -
-Carboplatin Common antimetabolite drugs: - -
Azacitidine
Capecitabine
These agents are typically categorized as highly 5-FU
emetogenic: - -1. Alkylating agents Cytarabine
2. Nitrosoureas Decitabine
Methotrexate
Pre-administration labs for alkylating agents and
nitrosoureas: - -BUN The institute for Safe Medication Practices
Complete Solutions
3 major phases of cell division: - -
Interphase
Mitotic phase Define neoadjuvant therapy - -Treatment is
Cytokinesis given prior to surgery to shrink the tumor
3 steps of interphase: - -First growth phase Define adjuvant therapy - -Additional
(G1) cancer treatment given after the primary
Synthesis phase (S phase) treatment to lower the risk that the cancer
Second growth phase (G2) reoccur
4 phases of mitosis: - -Prophase Define conditioning/preparative therapy - -
Metaphase Treatments used to prepare a patient for stem
Anaphase cell transplantation
Telophase
2 types of conditioning therapies: - -
Innate immunity: - -Non-specific response, Myeloablative
either: Nonmyeloablative
1. Barrier (skin, mucous membranes, flora of
skin/gut)
2. Cellular components (phagocytes, natural Define dose density - -Drug dose per unit
killer cells, granulocytes, macrophages) of time
Adaptive immunity: - -Follows innate Define dose intensity - -Amount of drug
immunity if unsuccessful. Memory immunity, delivered over time
including:
1. Humoral immunity (production of antibodies or
immunoglobulins) How is relative dose intensity (RDI) calculated? -
2. Cell mediated immunity (dependent upon T -By comparing the dose that the patient
cells) ACTUALLY received to the planned dose of the
3. Regulatory T -cells (prevent autoimmune standard regimen
reactions and limit inflammatory responses)
How do alkylating agents work? - -By
Define mutations - -Variations in the causing a break in the DNA helix strand,
nucleotide sequence of a gene interfering with DNA replication and causing cell
death
3 main goals of treatment: - -Cure
Control 3 subcategories of alkylating agents: - -1.
Palliation
, ONS Chemotherapy Immunotherapy Certificate with
Complete Solutions
Nitrogen mustards Creatinine
2. Platinum-based agents (do not possess an CBC w/ diff
alkyl group but still termed alkylating agents as
they work similarly)
3. Nitrosoureas What is the medication Mesna used for? - -
Bladder protectant with administration of
cyclophosphamide or ifosfamide
Most common subcategory of alkylating agents: -
-Nitrogen mustards
Instruct pts receiving ________ to avoid
exposure to cold air and consuming cold fluids for
Common alkylating agents: - - 3-4 days following treatment - -Oxaliplatin
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda) How do antimetabolites function? - -By
blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Common platinum-based agents: - -
Cisplatin (Platinol)
Carboplatin (Paraplatin) Antimetabolites work in the ___ phase. - -S
What is unique about nitrosoureas agents? - What types of cells are best affected by
-Able to cross the blood-brain barrier; can antimetabolites? - -Cells with high division
be effective in treating some brain tumors rates
Common nitrosoureas agents: - - Common side effects of antimetabolites: - -
Carmustine (BiCNU) Myelosuppression
Lomustine (CeeNu) GI toxicities
Streptozocin (Zanosar) Photosensitivity
Hand-foot syndrome
Hypersensitivity can occur with late doses of: -
-Carboplatin Common antimetabolite drugs: - -
Azacitidine
Capecitabine
These agents are typically categorized as highly 5-FU
emetogenic: - -1. Alkylating agents Cytarabine
2. Nitrosoureas Decitabine
Methotrexate
Pre-administration labs for alkylating agents and
nitrosoureas: - -BUN The institute for Safe Medication Practices
