Usmle Step 1 1 of 659
Usmle Step 1
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Terms in this set (2000)
??? -> +TGF beta -> Hepatic stellate cell
cirrhosis
2/5/2026 1
,Usmle Step 1 2 of 659
??? -> aortic regurgitation + aortic aneurysm
mediastinal widening.
???? -> damages mitochondria -> alcohol
AST release from mitochondria ->
AST > ALT
??? -> Primary hemochromatosis HFE c282y
??? -> Ventricular tachycardia -> hypertrophic cardiomyopathy
ventricular fibrillation -> sudden
death in previously health
asymptomatic person <30yo.
2/5/2026 2
,Usmle Step 1 3 of 659
??? -> X lysyl oxidase -> beta aminopropionitrile
X elastin/collagen crosslinking ->
aortic dissection.
1,3 beta glucan -> polysaccharide caspofungin
-> echinocandin
fungal cell WALL (not membrane).
What drug blocks glucan
synthesis?
1st degree AV block prolonged PR interval
2/5/2026 3
, Usmle Step 1 4 of 659
2nd degree AV block - Mobitz type I = Wenckebach - progressive lengthening
type I and II of PR interval until a QRS is dropped
- which is Wenckebach? type II - no lengthening of PR interval, but
occasional dropped beats
3-4 months of drug therapy -> phenytoin
+PDGF ->
+macrophages -> +TGF beta ->
gingival hyperplasia.
What drug?
2/5/2026 4
Usmle Step 1
Save
Terms in this set (2000)
??? -> +TGF beta -> Hepatic stellate cell
cirrhosis
2/5/2026 1
,Usmle Step 1 2 of 659
??? -> aortic regurgitation + aortic aneurysm
mediastinal widening.
???? -> damages mitochondria -> alcohol
AST release from mitochondria ->
AST > ALT
??? -> Primary hemochromatosis HFE c282y
??? -> Ventricular tachycardia -> hypertrophic cardiomyopathy
ventricular fibrillation -> sudden
death in previously health
asymptomatic person <30yo.
2/5/2026 2
,Usmle Step 1 3 of 659
??? -> X lysyl oxidase -> beta aminopropionitrile
X elastin/collagen crosslinking ->
aortic dissection.
1,3 beta glucan -> polysaccharide caspofungin
-> echinocandin
fungal cell WALL (not membrane).
What drug blocks glucan
synthesis?
1st degree AV block prolonged PR interval
2/5/2026 3
, Usmle Step 1 4 of 659
2nd degree AV block - Mobitz type I = Wenckebach - progressive lengthening
type I and II of PR interval until a QRS is dropped
- which is Wenckebach? type II - no lengthening of PR interval, but
occasional dropped beats
3-4 months of drug therapy -> phenytoin
+PDGF ->
+macrophages -> +TGF beta ->
gingival hyperplasia.
What drug?
2/5/2026 4
