Comprehensive Multiple Sclerosis:, STUDY
GUIDE WITH COMPLETE SOLUTIONS
etiology of multiple sclerosis
environmental trigger before puberty in genetically susceptible individuals
-autoimmune component
demographics for multiple sclerosis
-age 20-50
-subset of pediatric MS
-women>men
-more common in northern European descent
pathophysiology of multiple sclerosis
-chronic neuroimmunologic disease of CNS
-UMN
-Inflammatory plaques or lesion during relapse
-or non-inflammatory: neurodegeneration-axonal transection
relapse definition
-new or increased symptoms
-lasts more than 24 hours up to 1-2 months
pseudorelapse defintion
-increase in symptoms
, -less than 24 hrs
-not damaging/not inflammatory
-usually due to exercise, heat, fatigue, UTI
most common clinical features of multiple sclerosis (related to PT)
-fatigue
-heat intolerance
-weakness (primary/secondary)
-decreased aerobic capacity
-impaired balance/ataxia
-sensory loss
-hypertonicity/spasticity
other clinical signs of multiple sclerosis
-bowel and bladder dysfunction
-speech/swallowing impairment
-sleep disturbances
-sexual dysfunction
-impaired cognition
-pain
-depression
-emotional issues
-impaired vision
GUIDE WITH COMPLETE SOLUTIONS
etiology of multiple sclerosis
environmental trigger before puberty in genetically susceptible individuals
-autoimmune component
demographics for multiple sclerosis
-age 20-50
-subset of pediatric MS
-women>men
-more common in northern European descent
pathophysiology of multiple sclerosis
-chronic neuroimmunologic disease of CNS
-UMN
-Inflammatory plaques or lesion during relapse
-or non-inflammatory: neurodegeneration-axonal transection
relapse definition
-new or increased symptoms
-lasts more than 24 hours up to 1-2 months
pseudorelapse defintion
-increase in symptoms
, -less than 24 hrs
-not damaging/not inflammatory
-usually due to exercise, heat, fatigue, UTI
most common clinical features of multiple sclerosis (related to PT)
-fatigue
-heat intolerance
-weakness (primary/secondary)
-decreased aerobic capacity
-impaired balance/ataxia
-sensory loss
-hypertonicity/spasticity
other clinical signs of multiple sclerosis
-bowel and bladder dysfunction
-speech/swallowing impairment
-sleep disturbances
-sexual dysfunction
-impaired cognition
-pain
-depression
-emotional issues
-impaired vision
