1|Page
WHNP Boards 2026 | Newest Exam
Questions And Verified Answers
Estrogen associated with reproductive years? - correct-answer -Estradiol
Estrogen associated with pregnancy? - correct-answer -Estriol
Estrogen associated with menopause? - correct-answer -Estrone
What is sex hormone binding globulin? - correct-answer -- sex hormones are
hydrophobic, this is their transport protein
- 65% of testosterone bound
- 60% of estrogen bound
Levels are low in PCOS, diabetes, hypothyroid
High levels in pregnancy and hyperthyroid
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What are the phases associated with the endometrium? - correct-answer -
Proliferative or secretory
What are the phases associated with the ovary? - correct-answer -Follicular or
luteal phase
What is the mechanism of action of methotrexate? - correct-answer -An anti-
folate blocks division of rapidly dividing cells, prevent placental villi proliferation
What is a mechanism of action of mifepristone? - correct-answer -Anti-
progestin/progesterone antagonist
Blocks progestin on the individual growth, detaches the embryo
3 criteria for lactational amenorrhea method? - correct-answer -Breastfeeding
exclusively
Amenorrhoeic
Infant less than 6 months old
When is the fertile window? - correct-answer -8 - 19, should abstain or use barrier
method
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Mechanism of action for emergency contraception? - correct-answer -Inhibit or
delay ovulation
Interfere with fertilization
Plan B - correct-answer -Take first dose within 72 hours but also effective for up to
120 hours. Can be obtained OTC
Ella - correct-answer -Take one 30mg tablet up to 5 days after intercourse
Paragard - correct-answer -MOST EFFECTIVE EC
99.9% effective as emergency contraception if placed within 5 days of unprotected
intercourse
How often is Depo-Provera given? - correct-answer -Every 11-13 weeks
Adverse effects of progestin only pills? - correct-answer -Unscheduled bleeding
due to atrophy of the endometrium, mood swings, breast tenderness
, 4|Page
Treat with NSAIDs
Non-contraceptive benefits of oral contraceptives? - correct-answer -Cancer
reduction
Prevention of bone loss
Fibrocystic symptoms
Decrease PID
Improve acne and hirsutism (increase sex hormone binding globulin)
Improvement of PMS and endometritis
What is the pharmacologic action of progesterone as contraception? - correct-
answer -Secretion of FSH inhibits ovulation, thinning cervical mucus, endometrial
proliferation, improve cycle control by stabilizing the endometrium
Labs that may be seen with premature ovarian insufficiency - correct-answer -FSH
> 30
Estradiol < 50
Rotterdam criteria for PCOS - correct-answer -(Needs 2 of 3 for diagnosis)
Ovulatory dysfunction
WHNP Boards 2026 | Newest Exam
Questions And Verified Answers
Estrogen associated with reproductive years? - correct-answer -Estradiol
Estrogen associated with pregnancy? - correct-answer -Estriol
Estrogen associated with menopause? - correct-answer -Estrone
What is sex hormone binding globulin? - correct-answer -- sex hormones are
hydrophobic, this is their transport protein
- 65% of testosterone bound
- 60% of estrogen bound
Levels are low in PCOS, diabetes, hypothyroid
High levels in pregnancy and hyperthyroid
,2|Page
What are the phases associated with the endometrium? - correct-answer -
Proliferative or secretory
What are the phases associated with the ovary? - correct-answer -Follicular or
luteal phase
What is the mechanism of action of methotrexate? - correct-answer -An anti-
folate blocks division of rapidly dividing cells, prevent placental villi proliferation
What is a mechanism of action of mifepristone? - correct-answer -Anti-
progestin/progesterone antagonist
Blocks progestin on the individual growth, detaches the embryo
3 criteria for lactational amenorrhea method? - correct-answer -Breastfeeding
exclusively
Amenorrhoeic
Infant less than 6 months old
When is the fertile window? - correct-answer -8 - 19, should abstain or use barrier
method
,3|Page
Mechanism of action for emergency contraception? - correct-answer -Inhibit or
delay ovulation
Interfere with fertilization
Plan B - correct-answer -Take first dose within 72 hours but also effective for up to
120 hours. Can be obtained OTC
Ella - correct-answer -Take one 30mg tablet up to 5 days after intercourse
Paragard - correct-answer -MOST EFFECTIVE EC
99.9% effective as emergency contraception if placed within 5 days of unprotected
intercourse
How often is Depo-Provera given? - correct-answer -Every 11-13 weeks
Adverse effects of progestin only pills? - correct-answer -Unscheduled bleeding
due to atrophy of the endometrium, mood swings, breast tenderness
, 4|Page
Treat with NSAIDs
Non-contraceptive benefits of oral contraceptives? - correct-answer -Cancer
reduction
Prevention of bone loss
Fibrocystic symptoms
Decrease PID
Improve acne and hirsutism (increase sex hormone binding globulin)
Improvement of PMS and endometritis
What is the pharmacologic action of progesterone as contraception? - correct-
answer -Secretion of FSH inhibits ovulation, thinning cervical mucus, endometrial
proliferation, improve cycle control by stabilizing the endometrium
Labs that may be seen with premature ovarian insufficiency - correct-answer -FSH
> 30
Estradiol < 50
Rotterdam criteria for PCOS - correct-answer -(Needs 2 of 3 for diagnosis)
Ovulatory dysfunction
