EKU NSC 830 Adv Pharm Exam Questions With
Correct Answers
Distribution |- |CORRECT |ANSWER✔✔-Drug |movement |from |the |blood |to |tissues |and |cells
What |is |Distribution |Affected |by? |- |CORRECT |ANSWER✔✔-Protein |binding, |blood |flow |to |the |
tissues, |ability |of |the |drug |to |exit |the |vascular |space, |and |the |ability |of |the |drug |to |enter |the |
cell
What |do |most |drugs |bind |with |- |CORRECT |ANSWER✔✔-plasma |protein |- |albumin
What |does |plasma |protein |albumin |do |after |binding |w |drugs |- |CORRECT |ANSWER✔✔-acts |as |a
|carrier
Bound |drug |molecules |are |considered |- |CORRECT |ANSWER✔✔-inactive
Unbound/Free |drug |molecules |are |considered |- |CORRECT |ANSWER✔✔-active
What |portion |of |the |drug |acts |on |body |cells |- |CORRECT |ANSWER✔✔-the |free |or |unbound |
portion
If |a |drug |molecules |is |bound |to |plasma |protein, |why |is |it |considered |inactive? |- |CORRECT |
ANSWER✔✔-It |is |too |big |to |cross |over |into |the |tissues |from |the |plasma
In |order |for |drugs |to |cross |the |Blood |Brain |Barrier |they |must |be: |- |CORRECT |ANSWER✔✔-Un-
ionized, |small |molecules, |and |lipid |soluable
, in |order |for |drugs |to |pass |the |placental |barrier |they |must |be: |- |CORRECT |ANSWER✔✔-Lipid |
soluable, |smaller |molecule |drugs, |and |there |must |be |passive |diffusion
Metabolism |- |CORRECT |ANSWER✔✔-the |process |of |chemically |changing |a |drug |to |a |different |
compound |called |a |metabolite
What |are |active |drugs |changed |into |in |order |to |be |excreted? |- |CORRECT |ANSWER✔✔-one |or |
more |inactive |metabolites
A |function |of |Metabolism: |- |CORRECT |ANSWER✔✔-Changing |from |an |active |metabolite |to |an |
inactive |metabolite |OR |changing |from |an |inactive |metabolite |to |an |active |metabolite.
If |a |drug |is |administered |as |an |inactive |pro-drug |what |must |happen |for |the |drug |to |have |an |
effect? |- |CORRECT |ANSWER✔✔-The |drug |must |be |metabolized |to |an |active |metabolite |from |
the |inactive |pro-drug |state |to |have |an |effect
What |must |happen |to |drugs |in |order |to |be |excreted |by |the |kidneys? |- |CORRECT |ANSWER✔✔-
they |must |be |converted |from |lipid |soluble |to |water |soluble |metabolites
What |is |the |main |site |of |drug |metabolism? |- |CORRECT |ANSWER✔✔-The |liver
Other |than |the |liver |(main |site) |where |else |can |drugs |be |metabolized? |- |CORRECT |
ANSWER✔✔-Lungs, |Kidneys, |placenta, |and |intestinal |mucosa
What |is |another |name |(the |main |name) |for |the |Hepatic |microsomal |enzyme |system? |- |
CORRECT |ANSWER✔✔-Cytachrome |P450 |system |(CYP |450)
Correct Answers
Distribution |- |CORRECT |ANSWER✔✔-Drug |movement |from |the |blood |to |tissues |and |cells
What |is |Distribution |Affected |by? |- |CORRECT |ANSWER✔✔-Protein |binding, |blood |flow |to |the |
tissues, |ability |of |the |drug |to |exit |the |vascular |space, |and |the |ability |of |the |drug |to |enter |the |
cell
What |do |most |drugs |bind |with |- |CORRECT |ANSWER✔✔-plasma |protein |- |albumin
What |does |plasma |protein |albumin |do |after |binding |w |drugs |- |CORRECT |ANSWER✔✔-acts |as |a
|carrier
Bound |drug |molecules |are |considered |- |CORRECT |ANSWER✔✔-inactive
Unbound/Free |drug |molecules |are |considered |- |CORRECT |ANSWER✔✔-active
What |portion |of |the |drug |acts |on |body |cells |- |CORRECT |ANSWER✔✔-the |free |or |unbound |
portion
If |a |drug |molecules |is |bound |to |plasma |protein, |why |is |it |considered |inactive? |- |CORRECT |
ANSWER✔✔-It |is |too |big |to |cross |over |into |the |tissues |from |the |plasma
In |order |for |drugs |to |cross |the |Blood |Brain |Barrier |they |must |be: |- |CORRECT |ANSWER✔✔-Un-
ionized, |small |molecules, |and |lipid |soluable
, in |order |for |drugs |to |pass |the |placental |barrier |they |must |be: |- |CORRECT |ANSWER✔✔-Lipid |
soluable, |smaller |molecule |drugs, |and |there |must |be |passive |diffusion
Metabolism |- |CORRECT |ANSWER✔✔-the |process |of |chemically |changing |a |drug |to |a |different |
compound |called |a |metabolite
What |are |active |drugs |changed |into |in |order |to |be |excreted? |- |CORRECT |ANSWER✔✔-one |or |
more |inactive |metabolites
A |function |of |Metabolism: |- |CORRECT |ANSWER✔✔-Changing |from |an |active |metabolite |to |an |
inactive |metabolite |OR |changing |from |an |inactive |metabolite |to |an |active |metabolite.
If |a |drug |is |administered |as |an |inactive |pro-drug |what |must |happen |for |the |drug |to |have |an |
effect? |- |CORRECT |ANSWER✔✔-The |drug |must |be |metabolized |to |an |active |metabolite |from |
the |inactive |pro-drug |state |to |have |an |effect
What |must |happen |to |drugs |in |order |to |be |excreted |by |the |kidneys? |- |CORRECT |ANSWER✔✔-
they |must |be |converted |from |lipid |soluble |to |water |soluble |metabolites
What |is |the |main |site |of |drug |metabolism? |- |CORRECT |ANSWER✔✔-The |liver
Other |than |the |liver |(main |site) |where |else |can |drugs |be |metabolized? |- |CORRECT |
ANSWER✔✔-Lungs, |Kidneys, |placenta, |and |intestinal |mucosa
What |is |another |name |(the |main |name) |for |the |Hepatic |microsomal |enzyme |system? |- |
CORRECT |ANSWER✔✔-Cytachrome |P450 |system |(CYP |450)
