NSC 830 Variables w Pharmacology Exam Questions With Correct Answers

NSC 830 Variables w Pharmacology Exam
Questions With Correct Answers

Drug-Diet |Interactions |- |CORRECT |ANSWER✔✔-1. |Food |may |slow |absorption |by |slowing |
gastric |emptying |time



2. |Food |may |form |an |insoluble |compound

*Ex |= |tetracycline |& |dairy |products |

(tetracycline |combines |with |calcium |& |forms |unabsorbable |compound)



3. |Tyramine |containing |foods |& |MAO |inhibitor

causes |release |of |norepinephrine |& |produces |severe |hypertension



4. |Warfarin |(Coumadin) |and |foods |with |vitamin |K

| Vitamin |K |(in |green, |leafy |vegetables) |antagonizes |action |of |warfarin



Drug-Drug |Interactions |- |CORRECT |ANSWER✔✔-Interactions |that |can |increase |the |therapeutic |

or |adverse |effects |of |drugs



Additive |effect |- |CORRECT |ANSWER✔✔-Two |drugs |w |similar |actions |that |can |increase |the |
therapeutic |or |adverse |effects |of |drugs |(ex:alcohol |w |sedative |drug)



Synergism |or |potentiation |- |CORRECT |ANSWER✔✔-Two |drugs |w |different |mechanisms |of |
action |that |produce |greater |effects |when |taken |together |(ex: |Acetaminophen |+ |codein |= |
Tylenol |#3)

, Drug-Drug |interaction |- |Interference |- |CORRECT |ANSWER✔✔-Interference |by |one |drug |with |
the |metabolism |or |elimination |of |a |2nd |drug |results |in |increased |effects |of |2nd |drug

Example: |cimetidine |(Tagamet) |inhibits |drug |metabolizing |enzymes |in |the |liver |

(thus, |decreased |metabolism |of |many |drugs |such |as |benzodiazepines, |beta-blockers, |
theophylline)



Drug-Drug |interaction |- |Displacement |- |CORRECT |ANSWER✔✔-Displacement |of |one |drug |from
|plasma |protein |binding |sites |by |a |2nd |drug |= |increased |effects |of |displaced |drug



Example: |Warfarin |(Coumadin) |+ |aspirin |= |increased |anticoagulant |effect |of |Warfarin



Drug-Drug |Interaction |- |Antidote |- |CORRECT |ANSWER✔✔-Interactions |in |which |drug |effects |
are |decreased

Given |to |antagonize |the |toxic |effects |of |another |drug.

Example: |naloxone |(Narcan)



Drug-Drug |Interaction |- |Decreased |intestinal |absorption |- |CORRECT |ANSWER✔✔-When |oral |
drugs |combine |to |produce |unabsorbable |compounds.

Example: |antacids |taken |with |tetracyclin



Drug-Drug |Interaction |- |Interactions |in |which |

drug |effects |are |decreased |- |CORRECT |ANSWER✔✔-Activation |of |drug-metabolizing |enzymes |
in |the |liver

1. |Increases |the |metabolism |rate |of |any |drug |metabolized |primarily |in |the |liver

Example: |phenobarbital |(enzyme |"inducer") |+ |warfarin |(Coumadin) |= |decreased |effect |of |
warfarin

2. |Increased |excretion |occurs |when |urinary |pH |is |changed |and |renal |absorption |is |blocked

Example: |Sodium |Bicarbonate |(alkalinizes |the |urine) |+ |phenobarbital |= |increased |excretion |of |
phenobarbital