Logp Guías de estudio, Notas de estudios & Resúmenes

ILE 3 - Final Exam Questions And Answers 100% Correct (2024 New Update) I - ANS-biopharm class ___ has a high solubility and high permeability II - ANS-biopharm class ___ has a low solubility and a high permeability III - ANS-biopharm class ___ has a high solubility and a low permeability IV - ANS-biopharm class ___ has a low solubility and a low permeability metoprolol - ANS-example from class of drug in biopharm class I carbamazepine - ANS-example from class of drug in biopharm class II ...

GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equili...

I - Answer- biopharm class ___ has a high solubility and high permeability II - Answer- biopharm class ___ has a low solubility and a high permeability III - Answer- biopharm class ___ has a high solubility and a low permeability IV - Answer- biopharm class ___ has a low solubility and a low permeability metoprolol - Answer- example from class of drug in biopharm class I carbamazepine - Answer- example from class of drug in biopharm class II metformin - Answer- example from cla...

Antibodies and RNA-based therapeutics belong to a new class of therapeutics called "biologics". - Answer True Dosage form of a medication usually has little to do with clinical effectiveness of the drug. - Answer False The "Pharmacokinetics" of a drug refers to the time course of drug concentration in the body after administration, and most often in the systemic circulation. - Answer True Clinical factors (e.g. diseases, genetics, age), but not dosing regimen (e.g. dose, dosag...

The salting-out effect is attributed to a competition between solute molecules for the solvent - Answer TRUE Packaging of a drug is usually not considered to be part of compounding of a dosage form - Answer FALSE Solutions are homogenous liquid mixtures in which the solute is dispersed throughout the solvent in molecule sized particles - Answer TRUE Hydrogen bonding is the main mechanism of water to dissolve alcohols - Answer TRUE Coca butter alpha melts at 23 C, beta at 35 C...

GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equili...

T/F: Regarding the membrane permeability coefficient (i.e. permeability or P) of a drug molecule: For a given membrane, permeability is determined by the physiochemical properties of the drug such as molecular size, lipophilicity and ionization state. - Answer T T/F: Regarding the membrane permeability coefficient (i.e. permeability or P) of a drug molecule: For non-polar drugs with similar molecular sizes, membrane permeability increases as the LogP value of the drug molecule increases. - ...

Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) - Log10(P) Improved Lipinski Parameters - ANSWER-1. Partition...

API Exam 1|236 Questions with Verified Answers Timeline for Nanomedicines rugs? - CORRECT ANSWER 1965 --> liposomes (lipid based vehicles drug inside membrane OR inside core) 1976 --> polymeric systems 1978 --> Dendrimers 1980 --> PEGylated liposomes (liposomes with PEG polymer on surface, which keeps the drug in circulation longer) 1995 --> doxil (PEGylated liposomes, one of the first drugs approved) 2013 --> Kadcyla (antibody drug) It's not necessa...

Lipinski's Rule of 5 - ANSWER-A successful drug meets these criteria: -LogP<5 -molecular weight <500 g/mol - hydrogen bond donors <5 -hydrogen bond acceptors <10 -rotatable bonds<10 logD - ANSWER-distribution between all forms of drug (logD<5) Polar surface area - ANSWER-the surface area of nitrogen's, oxygens, and their attached protons on a molecule What is the problem with Lipinski's rules - ANSWER-the majority of drugs that are being focused on only adhere ...