STUDENT C O M P A N I O N
F U N D A M
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Biochemistry
LIFE AT bv
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Akif Uzman Jerry Johnson Joseph Eichberg William Widger
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,STUDENT COMPANION TO ACCOMPANY bv bv bv
FUNDAMENTALS OF bv
BIOCHEMISTRY
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Fourth Edition bv
Akif Uzman
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University of Houston bv bv
Jerry Johnson bv
University of Houston bv bv
Joseph Eichberg bv
University of Houston bv bv
William Widger bv
University of Houston bv bv
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University of Pennsylvania bv bv
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JOHN WILEY & SONS, INC
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, Cover Designer Madelyn Lesure bv bv bv
Cover Illustration Norm Christiansen
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Cover Photos
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(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy bv bv bv bv bv bv bv
Molecular structures clockwise from top: based on X-ray structures that were respectively determined
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by Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of Tennessee; Thomas
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Steitz, Yale University; Alfonso Mondragón, Northwestern University; Venki Ramakrishnan, MRC
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Laboratory of Molecular Biology, Cambridge, U.K.; Andrew Leslie and John Walker, MRC Laboratory
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of Molecular Biology, Cambridge, U.K.
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Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for
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more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our
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company is built on a foundation of principles that include responsibility to the communities we serve and
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where we live and work. In 2008, we launched a Corporate Citizenship Initiative, a global effort to address
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the environmental, social, economic, and ethical challenges we face in our business. Among the issues we
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are addressing are carbon impact, paper specifications and procurement, ethical conduct within our
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business and among our vendors, and community and charitable support. For more information, please
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visit our website: www.wiley.com/go/citizenship.
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Copyright © 2012 bv bv John Wiley & Sons, Inc. bv bv bv bv
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
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transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or
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otherwise, except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act,
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without either the prior written permission of the Publisher, or authorization through payment of the
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appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA
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01923, website www.copyright.com. Requests to the Publisher for permission should be addressed to the
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Permissions Department, John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030-5774, (201)
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748-6011, fax (201) 748-6008, website http://www.wiley.com/go/permissions.
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To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
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Student Companion (paperback) bv bv ISBN-13 978-1-1182-1827-3 b v
Printed in the United States of America
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10 9 8 7 6 5 4 3 2 1
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F U N D A M
b v
E N T A L S O F
Biochemistry
LIFE AT bv
THE
b v MOLECULAR
LEVEL
v
b
Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William Widger
bv b v bv bv
Donald Voet Judith G. Voet Charlotte W. Pratt
bv bv bv bv bv bv
,This page is intentionally left blank
bv bv bv bv bv
,STUDENT COMPANION TO ACCOMPANY bv bv bv
FUNDAMENTALS OF bv
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
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Fourth Edition bv
Akif Uzman
bv
University of Houston bv bv
Jerry Johnson bv
University of Houston bv bv
Joseph Eichberg bv
University of Houston bv bv
William Widger bv
University of Houston bv bv
Donald Voet bv
University of Pennsylvania bv bv
Judith G. Voet bv bv
Swarthmore College bv
Charlotte W. Pratt bv bv
Seattle, Washington bv
JOHN WILEY & SONS, INC
bv bv bv bv
, Cover Designer Madelyn Lesure bv bv bv
Cover Illustration Norm Christiansen
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Cover Photos
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(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy bv bv bv bv bv bv bv
Molecular structures clockwise from top: based on X-ray structures that were respectively determined
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by Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of Tennessee; Thomas
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Steitz, Yale University; Alfonso Mondragón, Northwestern University; Venki Ramakrishnan, MRC
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Laboratory of Molecular Biology, Cambridge, U.K.; Andrew Leslie and John Walker, MRC Laboratory
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of Molecular Biology, Cambridge, U.K.
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Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for
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more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our
bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv
company is built on a foundation of principles that include responsibility to the communities we serve and
bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv
where we live and work. In 2008, we launched a Corporate Citizenship Initiative, a global effort to address
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the environmental, social, economic, and ethical challenges we face in our business. Among the issues we
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are addressing are carbon impact, paper specifications and procurement, ethical conduct within our
bv bv bv bv bv bv bv bv bv bv bv bv bv
business and among our vendors, and community and charitable support. For more information, please
bv bv bv bv bv bv bv bv bv bv bv bv bv bv
visit our website: www.wiley.com/go/citizenship.
bv bv bv bv
Copyright © 2012 bv bv John Wiley & Sons, Inc. bv bv bv bv
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv
transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or
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otherwise, except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act,
bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv
without either the prior written permission of the Publisher, or authorization through payment of the
bv bv bv bv bv bv bv bv bv bv bv bv bv bv bv
appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA
bv bv bv bv bv bv bv bv bv bv bv bv bv bv
01923, website www.copyright.com. Requests to the Publisher for permission should be addressed to the
bv bv bv bv bv bv bv bv bv bv bv bv bv bv
Permissions Department, John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030-5774, (201)
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748-6011, fax (201) 748-6008, website http://www.wiley.com/go/permissions.
bv bv bv bv bv bv
To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
bv bv bv bv bv bv bv bv bv bv bv
Student Companion (paperback) bv bv ISBN-13 978-1-1182-1827-3 b v
Printed in the United States of America
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10 9 8 7 6 5 4 3 2 1
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