Alkylating agent Study guides, Study notes & Summaries

CPHON Chemotherapy and Biotherapy Exam 62 Questions with Verified Answers Cell cycle Specific Agents - CORRECT ANSWER Plant Alkaloids and Antimetabolites Plant Alkaloids - CORRECT ANSWER Etoposide (VP 16) Tenoposide (VM 26) Paclitaxel Docetaxel Topotecan Irinotecan Vincristine Vinblastine Vinorelbeline Antimetabolites - CORRECT ANSWER Mercaptopurine Thioguanine 5 Fluorouriacil Gemcitabine Fludarabine Cladribine Nelarabine Clofarabine Cytarabine Hydroxyurea Methotrexate...

BMTCN ATG - correct answer anti t-cell globulin prevents GVHD, graft failure premeds: Tylenol, corticosteroids, Benadryl SE: hypotension, chills, rigors, fevers, pulmonary edema serum sickness - correct answer ATG myalgias, arthralgias, fever, rash, hand/facial edema give steroids BCNU (carmustine) - correct answer alkylating agent pre/post hydration SE: n/v, nephrotoxicity (elevated creat), pulmonary toxicity (pulmonary fibrosis, acute lung injury) infusion rx: feeling drunk, hy...

BMTCNATG - correct answer anti t-cell globulin prevents GVHD, graft failure premeds: Tylenol, corticosteroids, Benadryl SE: hypotension, chills, rigors, fevers, pulmonary edema serum sickness - correct answer ATG myalgias, arthralgias, fever, rash, hand/facial edema give steroids BCNU (carmustine) - correct answer alkylating agent pre/post hydration SE: n/v, nephrotoxicity (elevated creat), pulmonary toxicity (pulmonary fibrosis, acute lung injury) infusion rx: feeling drunk, hypo...

ONS/ONCC Chemotherapy Immunotherapy Certification QUESTIONS WELL SOLVED 2022The stem cell divides, producing undifferentiated stem cells that are of what lineage? myeloid or lymphoid What cells do myeloid precursors turn into? red blood cells, white blood cells, and platelets What cells do lymphoid precursors turn into? specialized white blood cells called lymphocytes Granulocytes are basophils, eosinophils, neutrophils Agranuloyctes are T lymphocytes, B lymphocy...

FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY STUDY GUIDE EXAM WITH CORRECT AND VERRIFIED ANSWERS Alkylating Agents - CORRECT ANSWER-*MOA* -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups crosslinking DNA and interfering with its function *Classical* = carmustine, cyclophosphamide, mechlorethamine *Non-Classical* = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide - CORRECT ...

CPHON Exam 195 Questions with Verified Answers Classification of Methotrexate - CORRECT ANSWER antimetabolite (s-phase) Classification of mercaptopurine and thioguinine - CORRECT ANSWER antimetabolite(s-phase) Classification of fludarabine/nelarabine - CORRECT ANSWER anti-metabolite Classification of cytarabine/gemcitabine - CORRECT ANSWER antimetabolite Classification and sub-class of ironotecan/topotecan - CORRECT ANSWER Topoisomerase inhibitors (campotothecins) Classificatio...

the risk for significant bone marrow suppression (8) - correct answer advanced age (>65),poor nutritional status, preexisting autoimmune disease, DM, GI disorders, liver disease, or hematopoietic disease, and substance abuse. Cancer-induced bone marrow suppression (3) - correct answer a) dysfunctional hematopoietic cell within the bone marrow, b) bone marrow infiltration with tumor c)general exhaustion of bone marrow reserves solid tumor malignancies with the highest propensity to inf...

ONS CHEMO/BIO Exam With 100% Correct Answers 2023 Aklylating Agents -Cyclophosphamide -Cisplatin -Carboplatin -Oxaliplatin Cyclophosphamide (Cytoxan) Alkylating agent (cytotoxic antineoplastic) Kills rapidly growing cells by interrupting DNA/RNA synthesis Can cause bone marrow suppression, N/V, acute hemorrhagic cystitis*, alopecia Aggressive hydration pre and post infusion Cisplatin Vesicant Severe n/v Renal failure (hydration and electrolyte replacement) Ototoxicity,...

HESI Pharmacology Exam V5| 2021 / 2022 | Questions and Verified Answers (55 Q & A) QUESTION The nurse is reviewing the history and physical examination of a client who will be receiving asparaginase (Elspar), an antineoplastic agent. The nurse consults with the registered nurse regarding the administration of the medication if which of the following is documented in the client's history? a. Pancreatitis Answer: a. Pancreatitis Rationale: Asparaginase (Elspar) is contraindi...

Fundamentals of Chemotherapy Q&A Alkylating Agents - Correct Ans-*MOA* -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups cross-linking DNA and interfering with its function *Classical* = carmustine, cyclophosphamide, mechlorethamine *Non-Classical* = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide - Correct Ans--Classical alkylating agent *Toxicity - bone marrow suppression ...