BMTCN questions & answers graded A+

BMTCNATG - correct answer anti t-cell globulin prevents GVHD, graft failure premeds: Tylenol, corticosteroids, Benadryl SE: hypotension, chills, rigors, fevers, pulmonary edema serum sickness - correct answer ATG myalgias, arthralgias, fever, rash, hand/facial edema give steroids BCNU (carmustine) - correct answer alkylating agent pre/post hydration SE: n/v, nephrotoxicity (elevated creat), pulmonary toxicity (pulmonary fibrosis, acute lung injury) infusion rx: feeling drunk, hypotension (slow the rate, IVF) pulmonary fibrosis - correct answer dry hacking cough, dyspnea, fatigue, anorexia CXR steroids Busulfan - correct answer alkylating agent SE: mucositis, seizures, pulmonary fibrosis ("busulfan lung"), VOD, hyperpigmentation Carboplatin - correct answer alkylating agent hydrate during infusion antiemetics SE:renal insufficiency, neurotoxicity (peripheral neuropathy), acute hypersensitivity (7-9th dose), hypernatremia Cyclophosphamide - correct answer alkylating agent hydration, monitor I&O mesna SE: N/V, histamine rx, hemorrhagic cystitis (heme check, void frequently, IVF), SIADH (hyponatremia), cardiac toxicity, interstitial pneumonitis Cytarabine - correct answer antimetabolite SE: mucositis, diarrhea, chemical conjunctivitis (corticosteroid eye drops), cerebellar toxicity Etoposide - correct answer Topoisomerase II inhibitor acute anaphylactic rx with high doses (benadryl, corticosteroids) SE: mucositis, peripheral neuropathy (peds), plantar/palmar burning Fludarabine - correct answer antimetabolites SE: N/V, diarrhea ifosfamide - correct answer alkylating agent SE: encephalopathy, pulmonary toxicity, n/v Melphalan - correct answer alkylating agent cryotherapy SE: mucositis, diarrhea, typhlitis, CHF, renal toxicity Thiotepa - correct answer alkylating agent shower 2-3x day SE: mucositis, skin desquamation, pulmonary toxicity, VOD