Page 1 of 452
NBME CBSE EXAM NEWEST 2025 ACTUAL EXAM TEST
BANK| COMPLETE REAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED ANSWERS)
ALREADY GRADED A+| NBME CBSE EXAM PREP 2025
(BRAND NEW!!)
70yo M dies in a motor vehicle collision. Was undergoing
evaluation for occult blood in the stool. Photo of transverse colon
shown. Dx? ........ANSWER......Tubular adenoma
38yo M with 1-week hx of watery, itchy eyes and a runny nose.
Physical shows inflamed nasal mucosa. No congestion in lower
lung. Pharmacotherapy? ........ANSWER......Loratadine
16yo girl with 3-day hx of fever, nonproductive cough, and
fatigue. T 38.3, P 88/min, BP 102-70. PE shows pale
conjunctivae. CXR shows bilateral interstitial infiltrates. Blood
spontaenously agglutinates while awaiting transport to the
,Page 2 of 452
laboratory. Antibody isotypes causing agglutination?
........ANSWER......IgM
24yo M with small tender blisters on his penis 3 days after
unprotected sex. Photograph shown. Causal agent?
........ANSWER......HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the
forehead, eyelids, nose, and cheeks. Rash seems to be getting
worse since she moved from New York to Florida last year. Spicy
foods precipitate a flushing reaction that seems to exacerbate
the rash. PE shows erythema over the nose and cheeks, with
scattered telangiectasias and a few papules. Dx?
........ANSWER......Rosacea
53yo M returned from Africa, has fever, headache, and
abdominal discomfort. Received appropriate vaccinations prior
to the trip. T 39.4C. A wright-stained peripheral smear shown.
Dx? ........ANSWER......Malaria
,Page 3 of 452
68yo F with T2DM and hypertension that has been poorly
controlled despite hydrochlorothiazide treatment. BP 150/96,
Labs show serum glucose concentration of 130 and proteinuria. In
addition to current Rx, which is most appropriate
pharmacotherapy? ........ANSWER......Lisinopril
66yo M with stage IV colon cancer with 3-day hx of severe
diarrhea after receiving chemotherapy with fluorouracil,
leucovorin, and Irinotecan. prescribed opioid antidiarrheal agent
with no CNS effects. Which med? ........ANSWER......Loperamide
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
profuse, watery diarrhea for 8 hours despite a lack of oral
intake. Recently returned from a medical relief trip to a remove
village in Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows
dry skin and decreased capillary refill. Stool for occult blood is
negative; stool is gray and turbid. Gram stain shows gram-
, Page 4 of 452
negative, comma-shaped bacteria; no erythrocytes of leukocytes.
MOA of toxin? ........ANSWER......Activation of adenylyl cyclase
59yo F with gradual onset of lack of muscle control in her left
arm and leg. Sx 1 mo ago after dx with metastatic breast
cancer. PE shows ataxia of left upper and lower extremities.
Muscle strength, DTR, sensation, proprioception normal.
Metastatic tumor in which location? ........ANSWER......cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE
shows petechial rash, microcephaly, and hepatosplenomegaly.
Serologic test for CMV: IgG + in mother, + in newborn; IGM - in
mother, + in newborn. Explanation? ........ANSWER......Congenital
cytomegalovirus infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8
and 8 at 1/5 min. PE shows a bulging, fluod0filled mass
approximately 5 cm in diameter in the midline over the
lumbosacral region. No spontaneous movements of the lower
NBME CBSE EXAM NEWEST 2025 ACTUAL EXAM TEST
BANK| COMPLETE REAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED ANSWERS)
ALREADY GRADED A+| NBME CBSE EXAM PREP 2025
(BRAND NEW!!)
70yo M dies in a motor vehicle collision. Was undergoing
evaluation for occult blood in the stool. Photo of transverse colon
shown. Dx? ........ANSWER......Tubular adenoma
38yo M with 1-week hx of watery, itchy eyes and a runny nose.
Physical shows inflamed nasal mucosa. No congestion in lower
lung. Pharmacotherapy? ........ANSWER......Loratadine
16yo girl with 3-day hx of fever, nonproductive cough, and
fatigue. T 38.3, P 88/min, BP 102-70. PE shows pale
conjunctivae. CXR shows bilateral interstitial infiltrates. Blood
spontaenously agglutinates while awaiting transport to the
,Page 2 of 452
laboratory. Antibody isotypes causing agglutination?
........ANSWER......IgM
24yo M with small tender blisters on his penis 3 days after
unprotected sex. Photograph shown. Causal agent?
........ANSWER......HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the
forehead, eyelids, nose, and cheeks. Rash seems to be getting
worse since she moved from New York to Florida last year. Spicy
foods precipitate a flushing reaction that seems to exacerbate
the rash. PE shows erythema over the nose and cheeks, with
scattered telangiectasias and a few papules. Dx?
........ANSWER......Rosacea
53yo M returned from Africa, has fever, headache, and
abdominal discomfort. Received appropriate vaccinations prior
to the trip. T 39.4C. A wright-stained peripheral smear shown.
Dx? ........ANSWER......Malaria
,Page 3 of 452
68yo F with T2DM and hypertension that has been poorly
controlled despite hydrochlorothiazide treatment. BP 150/96,
Labs show serum glucose concentration of 130 and proteinuria. In
addition to current Rx, which is most appropriate
pharmacotherapy? ........ANSWER......Lisinopril
66yo M with stage IV colon cancer with 3-day hx of severe
diarrhea after receiving chemotherapy with fluorouracil,
leucovorin, and Irinotecan. prescribed opioid antidiarrheal agent
with no CNS effects. Which med? ........ANSWER......Loperamide
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
profuse, watery diarrhea for 8 hours despite a lack of oral
intake. Recently returned from a medical relief trip to a remove
village in Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows
dry skin and decreased capillary refill. Stool for occult blood is
negative; stool is gray and turbid. Gram stain shows gram-
, Page 4 of 452
negative, comma-shaped bacteria; no erythrocytes of leukocytes.
MOA of toxin? ........ANSWER......Activation of adenylyl cyclase
59yo F with gradual onset of lack of muscle control in her left
arm and leg. Sx 1 mo ago after dx with metastatic breast
cancer. PE shows ataxia of left upper and lower extremities.
Muscle strength, DTR, sensation, proprioception normal.
Metastatic tumor in which location? ........ANSWER......cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE
shows petechial rash, microcephaly, and hepatosplenomegaly.
Serologic test for CMV: IgG + in mother, + in newborn; IGM - in
mother, + in newborn. Explanation? ........ANSWER......Congenital
cytomegalovirus infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8
and 8 at 1/5 min. PE shows a bulging, fluod0filled mass
approximately 5 cm in diameter in the midline over the
lumbosacral region. No spontaneous movements of the lower
